Navigation Links
Keeping chromosomes from cuddling up

osco is also a member of UA's BIO5 Institute.

Hartl, Sarah J. Sweeney and Peter J. Knepler, both at the UA, and Bosco published their paper, "Condensin II Resolves Chromosomal Associations to Enable Anaphase I Segregation in Drosophila Male Meiosis," in the October 2008 issue of PLoS Genetics. Sweeney and Knepler were UA undergraduates when they conducted the research.

The National Institutes of Health and the National Science Foundation funded the research.

Learning how cells control chromosomes and how DNA is transcribed will lead to better understanding of how an organism's DNA affects the organism's final form.

Scientists have known for about 50 years that when chromosomes are in direct contact, the transcription machinery can choose to transcribe either the gene from the mother or the gene from the father.

Many researchers investigated how the specific genes were brought close together so that process, known as transvection, could happen.

Bosco wondered, what if the chromosomes stayed stuck together?

To find something that separated chromosomes, he looked for female fruit flies that were sterile because chromosomes in their eggs had stuck together.

Once he had those fruit flies, Hartl isolated the gene that kept the chromosomes from coming apart. He found that the gene coded for condensin II, indicating that the sterile flies couldn't make condensin II.

To be able to watch how condensin II affects chromosomes, the researchers used the salivary glands from normal Drosophila melanogaster fruit flies. Fruit fly salivary glands are unusual, because they have many copies of the same chromosome coiled together like a rope.

Hartl said, "You can actually see chromosomes, because the cells are so huge and the chromosomes are so huge."

The team inserted an additional gene into the chromosomes that would turn the condensin II-producing gene off at 77 F (21 C) and on at

Contact: Mari N. Jensen
University of Arizona

Page: 1 2 3

Related biology news :

1. A second career for a growth factor receptor: keeping nerve axons on target
2. Keeping an eye on the surroundings
3. Case Western Reserve University study looks at keeping migrant workers children healthy
4. New keys to keeping a diverse planet
5. Exploding chromosomes fuel research about evolution of genetic storage
6. UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes
7. Cold Spring Harbor Protocols features classic approaches for analyzing chromosomes
8. Fungi can tell us about the origin of sex chromosomes
9. Grant supports study of abnormal ring-shaped chromosomes
Post Your Comments:
Related Image:
Keeping chromosomes from cuddling up
(Date:8/25/2014)... diagnostic device invented at New Zealand,s University of ... field tool for rapidly detecting suspected viruses or ... of infection. , The breakthrough device, dubbed Freedom4, ... Biology main meeting. It takes advantage of a ... sequences in real-time, without the need for further ...
(Date:8/25/2014)... A family of proteins that promotes virus entry into ... of HIV and other viruses, University of Missouri researchers ... provides new insights into our understanding of not only ... viruses," said Shan-Lu Liu, M.D., Ph.D., associate professor in ... and Immunology. , The study was recently published in ...
(Date:8/25/2014)... and efficient cell separation from a device the size ... tilt-angle standing surface acoustic waves, according to a team ... do cell separation before analysis," said Tony Jun Huang, ... separation process affects the integrity of the cells, damages ... well.", Tilted-angle standing surface acoustic waves can separate cells ...
Breaking Biology News(10 mins):Revolutionary handheld DNA diagnostic unit allows lab-quality analysis in the field 2MU researchers discover protein's ability to inhibit HIV release 2MU researchers discover protein's ability to inhibit HIV release 3Tilted acoustic tweezers separate cells gently 2
... dont carry photo identification, so scientists from the Wildlife ... the service free of charge by creating a photographic ... as well. The researchers have developed ... male elephants, specifically by the shape and size of ...
... years, scientists have known that some people are biologically more ... been able to speculate why. In the August 15, ... University of Chicago report on a study that may help ... most likely to self-administer addictive drugs had a particular receptor ...
... into the pathology underlying a recently identified neurological ... by alterations in the same gene that causes ... overwhelmingly affects males, usually in their 50s, causing ... X syndrome manifests itself from birth and is ...
Cached Biology News:Male elephants get 'photo IDs' from scientists 2Nicotinic receptors may be important targets for treatment of multiple addictions 2Deep into the machinery of adult fragile X 2Deep into the machinery of adult fragile X 3
(Date:8/27/2014)... 2014 Remcom announces an update to ... features for the biomedical industry. The central biomedical ... Sensor, exclusive to the Bio-Pro version of the software. ... developed to calculate the biological effects of electromagnetic fields. ... to all versions to expand engineers’ post-processing options. , ...
(Date:8/26/2014)... 2014  NeuroSigma, Inc., a Los Angeles ... technologies, today announced that it has filed a registration ... Exchange Commission relating to a proposed initial public offering ... be offered and the price range for the proposed ... LLC will act as the book-running manager for the ...
(Date:8/26/2014)... team of engineers from Singapore has successfully piloted ... for satellite communications. , With the weight of ... constructing a lightweight, low power-consuming, wireless communication system ... has always been a challenge for system designers. ... Centre of Nanyang Technological University in Singapore launched ...
(Date:8/26/2014)... ALPHARETTA, Ga. , Aug. 26, 2014 /PRNewswire/ ... ambient biological sample collection, stabilization and transportation, announced ... with Laboratory Procurement Services, LLC (LPS) of ... ViveST line of products in the United ... a new class of ambient temperature dried biological ...
Breaking Biology Technology:Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update 2Remcom Announces Enhanced Biological Thermal Sensor and Other Biomedical Features in XFdtd EM Simulation Software Update 3ZigBee in the Sky 2ViveBio and Laboratory Procurement Services Sign Agreement for Distribution of the ViveST Line of Products 2
... (Nasdaq: BIOD ) will issue its first quarter ... the release of the company,s financial results, Biodel,s senior management ... provide an update on the company,s progress.  February ... year 2012 results will be distributed  ,  4:15 pm EST: ...
... TORONTO, Feb. 2, 2012  Dr. Tom Hudson, President and ... (OICR), today announced a new study to develop a ... care. The framework aims to integrate ... to provide improved and more targeted care for patients. ...
... 2, 2012 Cambrex Corporation (NYSE: CBM ... be released on Monday, February 6, 2012 after the ... a conference call to discuss the fourth quarter 2011 ...  When:  , Tuesday, February 7, 2012 at 8:30 a.m. ...
Cached Biology Technology:New Study Building Framework to Bring Personalized Medicine to the Clinic 2New Study Building Framework to Bring Personalized Medicine to the Clinic 3
tracking dye in electrophoresis; free acid, C 19 H 10 BrO 5 S; MW: 669.96...
... Last innovation from Magnetofection technology, SilenceMag ... system available. Simple, rapid and easy ... and non toxic. Specifically designed for ... silencing at very low doses of ...
... Last innovation from Magnetofection technology, ... delivery system available. Simple, rapid and ... compatible and non toxic. Specifically designed ... gene silencing at very low doses ...
... Test Plate consists of an anodized aluminum ... Organic Fluorescent Compounds embedded in polymerized matrix. ... BioTeks FLx800 and Synergy Multi-Detection Readers. This ... compliance while reducing the need for tedious ...
Biology Products: