Navigation Links
Keeping chromosomes from cuddling up
Date:11/27/2008

If chromosomes snuggle up too closely at the wrong times, the results can be genetic disaster.

Now researchers have found the molecular machines in fruit flies that yank chromosomes, the DNA-carrying structures, apart when necessary.

The machines, proteins called condensin II, separate chromosomes by twisting them into supercoils that kink up and therefore can no longer touch.

Scientists had known of condensin II but did not know how it functioned inside cells.

Keeping specific parts of chromosomes from touching can change how the instructions carried in the DNA are read, said research team leader Giovanni Bosco of The University of Arizona in Tucson.

"It's like picking up your favorite book and, depending on what chair you chose to sit in, it turned into a different story -- even though the printed words in the book never changed," Bosco, a UA assistant professor of molecular and cellular biology, wrote in an e-mail.

"This now changes the way we think about genetic information. Taking a literal reading of it is not what actually happens," he wrote. "Instead, context matters."

The team also found that condensin II plays a key role in making sure that fruit fly sperm cells each receive the proper number of chromosomes -- not too many, not too few.

Bosco suspects that condensin II plays the same role in the formation of human sperm and eggs.

Having too many or too few chromosomes in egg or sperm cells is the source of several important genetic disorders, including Down syndrome.

Abnormalities in chromosome number is also the cause of some miscarriages of early-term fetuses in humans.

The research will be published in two separate papers. "Chromosome Alignment and Transvection are Antagonized by Condensin II," by Tom A. Hartl and Helen F. Smith, UA doctoral students, and Bosco is scheduled for publication in the Nov. 28 issue of the journal Science. B
'/>"/>

Contact: Mari N. Jensen
mnjensen@email.arizona.edu
520-626-9635
University of Arizona
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. A second career for a growth factor receptor: keeping nerve axons on target
2. Keeping an eye on the surroundings
3. Case Western Reserve University study looks at keeping migrant workers children healthy
4. New keys to keeping a diverse planet
5. Exploding chromosomes fuel research about evolution of genetic storage
6. UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes
7. Cold Spring Harbor Protocols features classic approaches for analyzing chromosomes
8. Fungi can tell us about the origin of sex chromosomes
9. Grant supports study of abnormal ring-shaped chromosomes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Keeping chromosomes from cuddling up
(Date:3/2/2015)... Calif. , March 2, 2015 ... leading developer of human interface solutions, today announced ... that is designed to enable rapid and secure ... ID™ module for gaming is a turnkey solution ... the ability to quickly integrate fingerprint ID solutions ...
(Date:3/2/2015)... 2015  Businesses have a new option for ... Rankins Enterprises has announced the launch of a ... for businesses to protect their customers, personal data, ... Beconux is a biometric transaction processing system ... to an ATM machine, the new system fuses ...
(Date:3/2/2015)...   Neurotechnology , a provider of high-precision biometric, ... Software Development Kit (SDK). The SentiGaze algorithm enables ... webcams to track eye movements and generate heatmaps based ... can be used for applications such as analysis of ... SDK can also be used to develop interfaces for ...
Breaking Biology News(10 mins):Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3Personal Data Protection Company Launches New Product 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 3
... clean, local-source energy. Faster, more reliable technologies and ... Medical care tailored to your DNA, or neural ... and injuries. Five University of Pittsburgh faculty ... and technology as part of Faculty Early Career ...
... technology, researchers led by a Weill Cornell Medical College scientist ... about half of all prostate cancers. Estrogen-linked signaling helps ... by a chromosomal translocation, which in turn results in the ... cancers harbor a common recurrent gene fusion, and we believe ...
... life to thrive: temperature, or sunlight? The answer ... online this week in PNAS Early Edition, the explosion ... do with warmth than with light. The diversity ... strongly related to temperature, said University of Southern California ...
Cached Biology News:Pitt faculty receive awards to explore next-generation technologies 2Pitt faculty receive awards to explore next-generation technologies 3Pitt faculty receive awards to explore next-generation technologies 4Estrogen helps drive distinct, aggressive form of prostate cancer 2Estrogen helps drive distinct, aggressive form of prostate cancer 3What makes life go at the tropics? 2
(Date:3/2/2015)... and VANCOUVER, British Columbia , ... (CSE: IN; OTCQB: IMLFF), a clinical stage biopharmaceutical ... therapies, today announced that Craig Schneider , ... during a live webcast at VirtualInvestorConferences.com. ... http://VirtualInvestorConferences.com > click the red "register/ ...
(Date:3/2/2015)... , March 2, 2015  Asterias Biotherapeutics, Inc. (NYSE ... field of regenerative medicine, today announced that it will ... operating results on Tuesday, March 10, 2015 after the ... host a conference call and webcast on Tuesday, March ... Pacific to discuss the results and recent corporate developments. ...
(Date:3/2/2015)... 2015 Outside GC, the leading provider ... addition of Debbie Casey as a member of the ... space. , Debbie has spent over 20 ... Fresenius Medical Care North America in both legal and ... to work with Outside GC’s growing list of healthcare ...
(Date:2/27/2015)... SUMMERLAND, British Columbia , Feb. 27, ... XON ), a leader in synthetic biology, today announced ... Specialty Fruits (OSF), the pioneering agricultural company behind ... first non-browning apple. Through the acquisition, Intrexon expands its ... more appetizing and convenient for consumers while providing economic ...
Breaking Biology Technology:InMed Pharmaceuticals to Present Investor Webcast March 5 2Asterias Biotherapeutics to Report Fourth Quarter and Full Year 2014 Results on March 10, 2015 2Outside GC Expands Healthcare Team 2Intrexon to Acquire Okanagan Specialty Fruits 2Intrexon to Acquire Okanagan Specialty Fruits 3Intrexon to Acquire Okanagan Specialty Fruits 4
... Marinus Pharmaceuticals, a,developer of specialty therapeutics to treat ... Krayacich as president,and chief executive officer. Mr. Krayacich ... business development for ganaxolone, an adult and,pediatric epilepsy ... candidate., Mr. Krayacich brings more than 20 ...
... (Amex: NBS ),announced today that the new Southern Florida ... Miami, is targeted to open in,September. The center is being ... of this center, NeoStem has secured a key geographic,stronghold in ... as well as a,growing sophisticated South American presence., Chester ...
... Company hits key insulin and Apo AI(Milano), ... 5 /PRNewswire-FirstCall/ - SemBioSys Genetics Inc.,(TSX:SBS), a biotechnology ... and cardiovascular diseases, today announced its,2008 second quarter ... Insulin Program, - Submitted an ...
Cached Biology Technology:Marinus Pharmaceuticals Appoints John Krayacich as President and Chief Executive Officer 2Marinus Pharmaceuticals Appoints John Krayacich as President and Chief Executive Officer 3Marinus Pharmaceuticals Appoints John Krayacich as President and Chief Executive Officer 4NeoStem Forges Ahead in Its Plan to Open Adult Stem Cell Collection Centers in Key Locations that Can Serve as Hubs to Service Clients Nationwide 2NeoStem Forges Ahead in Its Plan to Open Adult Stem Cell Collection Centers in Key Locations that Can Serve as Hubs to Service Clients Nationwide 3SemBioSys announces second quarter 2008 financial and operational results 2SemBioSys announces second quarter 2008 financial and operational results 3SemBioSys announces second quarter 2008 financial and operational results 4SemBioSys announces second quarter 2008 financial and operational results 5SemBioSys announces second quarter 2008 financial and operational results 6SemBioSys announces second quarter 2008 financial and operational results 7SemBioSys announces second quarter 2008 financial and operational results 8SemBioSys announces second quarter 2008 financial and operational results 9SemBioSys announces second quarter 2008 financial and operational results 10SemBioSys announces second quarter 2008 financial and operational results 11SemBioSys announces second quarter 2008 financial and operational results 12SemBioSys announces second quarter 2008 financial and operational results 13
... (Ser385) Immunogen: ... acid region encompassing the human, ... Accession Number: ... Quality Assurance: Routinely evaluated ...
Mouse monoclonal [MN-8C4] to zona radiata ( Abpromise for all tested applications). Antigen: Purified eggshell proteins (zona radiata proteins and small amounts of zona pellucida proteins) from ...
CCNI Antibody...
...
Biology Products: