Navigation Links
Keeping chromosomes from cuddling up
Date:11/27/2008

If chromosomes snuggle up too closely at the wrong times, the results can be genetic disaster.

Now researchers have found the molecular machines in fruit flies that yank chromosomes, the DNA-carrying structures, apart when necessary.

The machines, proteins called condensin II, separate chromosomes by twisting them into supercoils that kink up and therefore can no longer touch.

Scientists had known of condensin II but did not know how it functioned inside cells.

Keeping specific parts of chromosomes from touching can change how the instructions carried in the DNA are read, said research team leader Giovanni Bosco of The University of Arizona in Tucson.

"It's like picking up your favorite book and, depending on what chair you chose to sit in, it turned into a different story -- even though the printed words in the book never changed," Bosco, a UA assistant professor of molecular and cellular biology, wrote in an e-mail.

"This now changes the way we think about genetic information. Taking a literal reading of it is not what actually happens," he wrote. "Instead, context matters."

The team also found that condensin II plays a key role in making sure that fruit fly sperm cells each receive the proper number of chromosomes -- not too many, not too few.

Bosco suspects that condensin II plays the same role in the formation of human sperm and eggs.

Having too many or too few chromosomes in egg or sperm cells is the source of several important genetic disorders, including Down syndrome.

Abnormalities in chromosome number is also the cause of some miscarriages of early-term fetuses in humans.

The research will be published in two separate papers. "Chromosome Alignment and Transvection are Antagonized by Condensin II," by Tom A. Hartl and Helen F. Smith, UA doctoral students, and Bosco is scheduled for publication in the Nov. 28 issue of the journal Science. B
'/>"/>

Contact: Mari N. Jensen
mnjensen@email.arizona.edu
520-626-9635
University of Arizona
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. A second career for a growth factor receptor: keeping nerve axons on target
2. Keeping an eye on the surroundings
3. Case Western Reserve University study looks at keeping migrant workers children healthy
4. New keys to keeping a diverse planet
5. Exploding chromosomes fuel research about evolution of genetic storage
6. UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes
7. Cold Spring Harbor Protocols features classic approaches for analyzing chromosomes
8. Fungi can tell us about the origin of sex chromosomes
9. Grant supports study of abnormal ring-shaped chromosomes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Keeping chromosomes from cuddling up
(Date:9/19/2014)... legume plants regulate their symbiotic relationship with soil ... through the plant structure from leaves into the ... in the roots. This collaborative study was conducted ... Biology, the Graduate University for Advanced Studies (SOKENDAI), ... in Japan. , Legumes, an important plant ...
(Date:9/18/2014)... GSA Bulletin study uses tree rings to ... Chaco Wash in northern New Mexico, USA. By determining ... willow, investigators were able to precisely date arroyo sedimentary ... this data with aerial imagery, LiDAR, longitudinal profiles, and ... , Arroyos are deep, oversized channels that have vertical ...
(Date:9/18/2014)... USA Miranda, a small, icy moon of Uranus, ... bodies in the solar system. Despite its relatively small ... intense resurfacing that resulted in the formation of at ... regions called coronae. , These coronae are visible ... least 200 km across. Arden corona, the largest, has ...
Breaking Biology News(10 mins):For legume plants, a new route from shoot to root 2Tree rings and arroyos 2Tree rings and arroyos 3Tree rings and arroyos 4Tree rings and arroyos 5Tree rings and arroyos 6Tree rings and arroyos 7Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7
... Fresh fruit and vegetables carry an abundance of bacteria on ... first study to assess the variety of these non-pathogenic bacteria, ... type of produce and cultivation practices. The results are published ... by Jonathan Leff and Noah Fierer at the University ...
... 100 women per day die from breast cancer in ... increase for women taking hormone replacement therapy to avoid ... Missouri scientist Salman Hyder may lead to treatments for ... along with an international team, found that hormone-therapy-related breast ...
... A recent study published in the Journal of ... property rights discourage subsequent scientific research. "The ... patent system is to provide incentives for the ... many have expressed concerns that patents may be impeding ...
Cached Biology News:Do intellectual property rights on existing technologies hinder subsequent innovation? 2
(Date:9/19/2014)... The new , Healthcare and Life Sciences Review , ... PharmaBoardroom.com for free download , looks beyond the ... in 2009, and the austerity measures that followed, to find ... of trouble. "Despite the crisis, Spain ... the general conditions to invest are favorable to the pharmaceutical ...
(Date:9/18/2014)... 2014 About POCT ... a clinical laboratory. It helps in making fast ... and medication. POCT is gaining popularity due to ... such as diabetes, heart disease, and obesity. It ... standardized to minimize errors during the diagnosis of ...
(Date:9/18/2014)... Mich. , Sept. 18, 2014  Health Enhancement Products, ... firm investigating early-stage algae bioactive compounds and metabolic processes, is ... the company,s board of directors. Ms. Nola E. Masterson ... investment advisor joined the board effective September 17, 2014. ... Masterson agree to join our board," states Andrew Dahl ...
(Date:9/18/2014)... D.C. (PRWEB) September 18, 2014 On ... Durbin and Sen. Jim Risch for National Lab Day ... projects from across the national laboratory system. Durbin and ... which aims to increase awareness of the reach of ... technologies and discoveries to address some of our nation's ...
Breaking Biology Technology:PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3POCT Market in China 2014-2018 2Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3
... MADISON - Rayovac and Sanyo have ... greater capacities and shorter charging times. , ,Sanyo will be ... recharge Nickel Metal Hydride, or NiMH, batteries in 15 minutes. ... a pressure control in each battery to regulates the charging ...
... Ken Schlager started a company, he looked to the ... around, Schlager is turning to the Center for Technology ... a cutting-edge technology that applies electromagnetic fields to wastewater ... a process that oxidizes wastewater and removes organic materials, ...
... technology drives business or business drives technology. Stop worrying ... rattling about how superior this technology is to that technology. ... if you have to ask, you probably already know and ... of inquiry is how much of your technological horsepower is ...
Cached Biology Technology:CTT - Bridging the states entrepreneurial gap 2CTT - Bridging the states entrepreneurial gap 3Technology as the engine of business innovation 2Technology as the engine of business innovation 3
... The StatMatic I provides a convenient and ... culture work. Used with an eight-port disposable ... not possible with multi-channel pipettes. The eight-port ... in volumes of 100, 200, 250, or ...
384 Well PCR Plate Carrier for Thermo-Sealer...
These 18x18 square No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick....
... are hydrophobic cover slips for in ... genomic arrays on glass slides., ... Hybri-slips do not adsorb probes. , ... to use. , Avoid RNA degradation-Hybri-slips ...
Biology Products: