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Keep your distance! Why cells and organelles don't get stuck
Date:8/30/2012

Biomembranes enclose biological cells like a skin. They also surround organelles that carry out important functions in metabolism and cell division. Scientists have long known in principle how biomembranes are built up, and also that water molecules play a role in maintaining the optimal distance between neighboring membranesotherwise they could not fulfill their vital functions. Now, with the help of computer simulations, scientists of the Technische Universitt Mnchen (TUM) and the Freie Universitt Berlin have discovered two different mechanisms that prevent neighboring membrane surfaces from sticking together. Their results appear in the Proceedings of the National Academy of Sciences.

Biomembranes consist of lipids, chain-like fat molecules stacked side by side. In the aqueous environment of cells, the lipids organize themselves into a so-called bilayer with fat-soluble "hydrophobic" ends of the molecular chains facing inward and water-soluble "hydrophilic" ends facing outward. If the water-soluble surfaces of two membranes come too close to each other, a pressure is generatedhydration repulsionthat prevents the membrane surfaces from touching. Between two intact biomembranes there is always a film of water just a few nanometers thick. Until now, however, it was unclear how hydration repulsion works on the molecular level.

By means of complex simulations, the scientists discovered two different mechanisms whose contribution depends on the distance between the membranes. If the membranes are separated by around one nanometer or more, the water molecules play the decisive role in holding them apart. Since they have to orient themselves simultaneously to the lipids of both membrane surfaces, they give up their preferred spatial arrangement. Then they function like "bumpers," pushing the membranes apart. When the separation is smaller, the lipids in the opposing membrane surfaces mutually inhibit their own mobility, and the repulsive f
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Contact: Patrick Regan
regan@zv.tum.de
49-089-289-10515
Technische Universitaet Muenchen
Source:Eurekalert  

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