Navigation Links
Keck Foundation funds study of biological interactions with nanomaterials

The University of Oregon has received a $1.6 million grant from the W.M. Keck Foundation to explore the biological effects of exposure to precisely engineered nanoparticles that are being designed for diagnostic and therapeutic uses.

The three-year grant from the Keck Foundations medical research program will involve six researchers: Mark Lonergan, Jim Hutchison and Andy Berglund, all UO professors of chemistry; UO biology professors Karen Guillemin and Eric Johnson; and Robert Tanguay, a professor of environmental and molecular toxicology at Oregon State University.

All are members of the Safer Nanomaterials and Nanomanufacturing Initiative (SNNI), directed by Hutchison and part of the Oregon Nanoscience and Microtechnologies Institute (ONAMI).

This award from the Keck Foundation puts us at the forefront of this quickly developing and promising field of nanotechnology, said UO President Dave Frohnmayer. Nanotechnology has been described as being in its discovery phase. This newly funded project means the University of Oregon, Oregon State University and the state, through ONAMI Oregons first Signature Research Center can help build a green roadmap for the field.

The interdisciplinary project is designed to help researchers understand potential biological interactions of engineered nanomaterials and develop design rules for the development of nanoparticles with enhanced biological properties. The researchers will produce specific structures of nanomaterials, investigate their interactions with biological systems and then design new materials and nanoparticle libraries that have specific biological responses.

The biological testing will involve laboratory experiments using zebrafish, an invertebrate animal model system that was first developed for research at the University of Oregon. With zebrafish, researchers can monitor tissue-specific interactions with nanoparticles, developmental and acute toxicity, and the impacts of exposure on gene regulation.

The researchers will address existing gaps in the field, from the basic construction of nanoparticles to how they interface with biological cells. As the foundation for the project, the group will build upon the library of gold nanoparticles created by Hutchison using his patented green-chemistry approach.

Our goal is to define the important interactions at the bio-nano interface, as well as the ground rules for producing nanoparticles that have very fine-tuned objectives, Hutchison said. The end results could lead to a variety of future therapeutics that specifically seek out and destroy cancer cells or promote desired cell growth for tissue regeneration.

The Keck Foundation funds will cover just under $1 million in graduate and faculty research, with the remainder going toward the purchase of equipment and space for housing it. The instruments will go into the Lorry I. Lokey Laboratories, the underground portion of the Integrated Science Complex, where some of the projects research will be conducted.


Contact: Jim Barlow
University of Oregon

Related biology news :

1. W.M. Keck Foundation funds study of friendly microbes
2. Digging in the dirt for lifes biochemical foundations
3. Protein folding: Building a strong foundation
4. WHO suspends Marburg work, appeals for new funds
5. Grand Challenges in Global Health initiative funds Yale project
6. European Commission funds EBI to do new research on synergies between bioinformatics and medical informatics
7. Federal grant funds research on novel HIV therapy
8. Bioartificial kidney under study at MCG
9. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
10. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
11. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
Post Your Comments:
(Date:4/15/2016)... 15, 2016 Research and ... Biometrics Market 2016-2020,"  report to their offering.  , ... , ,The global gait biometrics market is expected ... the period 2016-2020. Gait analysis generates ... be used to compute factors that are not ...
(Date:4/13/2016)... CHICAGO , April 13, 2016  IMPOWER physicians ... are setting a new clinical standard in telehealth ... By leveraging the higi platform, IMPOWER patients can ... weight, pulse and body mass index, and, when they ... quick and convenient visit to a local retail location ...
(Date:3/31/2016)... 31, 2016  Genomics firm Nabsys has completed a ... Barrett Bready , M.D., who returned to the company ... technical leadership team, including Chief Technology Officer, John ... Steve Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... launch of the Supplyframe Design Lab . Located in Pasadena, Calif., the ... future of how hardware projects are designed, built and brought to market. , ...
(Date:6/23/2016)... ... 23, 2016 , ... In a new case report published today in STEM ... who developed lymphedema after being treated for breast cancer benefitted from an injection of ... dealing with this debilitating, frequent side effect of cancer treatment. , Lymphedema ...
(Date:6/23/2016)...  Blueprint Bio, a company dedicated to identifying, protecting ... has closed its Series A funding round, according to ... "We have received a commitment from Forentis Fund that ... meet our current goals," stated Matthew Nunez . ... complete validation on the current projects in our pipeline, ...
(Date:6/23/2016)... 2016 On Wednesday, June 22, 2016, ... 0.22%; the Dow Jones Industrial Average edged 0.27% lower to ... down 0.17%. has initiated coverage on the following equities: ... (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... BIND ). Learn more about these stocks by accessing their ...
Breaking Biology Technology: