Navigation Links
Keck Foundation funds study of biological interactions with nanomaterials
Date:9/11/2007

The University of Oregon has received a $1.6 million grant from the W.M. Keck Foundation to explore the biological effects of exposure to precisely engineered nanoparticles that are being designed for diagnostic and therapeutic uses.

The three-year grant from the Keck Foundations medical research program will involve six researchers: Mark Lonergan, Jim Hutchison and Andy Berglund, all UO professors of chemistry; UO biology professors Karen Guillemin and Eric Johnson; and Robert Tanguay, a professor of environmental and molecular toxicology at Oregon State University.

All are members of the Safer Nanomaterials and Nanomanufacturing Initiative (SNNI), directed by Hutchison and part of the Oregon Nanoscience and Microtechnologies Institute (ONAMI).

This award from the Keck Foundation puts us at the forefront of this quickly developing and promising field of nanotechnology, said UO President Dave Frohnmayer. Nanotechnology has been described as being in its discovery phase. This newly funded project means the University of Oregon, Oregon State University and the state, through ONAMI Oregons first Signature Research Center can help build a green roadmap for the field.

The interdisciplinary project is designed to help researchers understand potential biological interactions of engineered nanomaterials and develop design rules for the development of nanoparticles with enhanced biological properties. The researchers will produce specific structures of nanomaterials, investigate their interactions with biological systems and then design new materials and nanoparticle libraries that have specific biological responses.

The biological testing will involve laboratory experiments using zebrafish, an invertebrate animal model system that was first developed for research at the University of Oregon. With zebrafish, researchers can monitor tissue-specific interactions with nanoparticles, developmental and acute toxicity, and the impacts of exposure on gene regulation.

The researchers will address existing gaps in the field, from the basic construction of nanoparticles to how they interface with biological cells. As the foundation for the project, the group will build upon the library of gold nanoparticles created by Hutchison using his patented green-chemistry approach.

Our goal is to define the important interactions at the bio-nano interface, as well as the ground rules for producing nanoparticles that have very fine-tuned objectives, Hutchison said. The end results could lead to a variety of future therapeutics that specifically seek out and destroy cancer cells or promote desired cell growth for tissue regeneration.

The Keck Foundation funds will cover just under $1 million in graduate and faculty research, with the remainder going toward the purchase of equipment and space for housing it. The instruments will go into the Lorry I. Lokey Laboratories, the underground portion of the Integrated Science Complex, where some of the projects research will be conducted.


'/>"/>

Contact: Jim Barlow
jebarlow@uoregon.edu
541-346-3481
University of Oregon
Source:Eurekalert

Related biology news :

1. W.M. Keck Foundation funds study of friendly microbes
2. Digging in the dirt for lifes biochemical foundations
3. Protein folding: Building a strong foundation
4. WHO suspends Marburg work, appeals for new funds
5. Grand Challenges in Global Health initiative funds Yale project
6. European Commission funds EBI to do new research on synergies between bioinformatics and medical informatics
7. Federal grant funds research on novel HIV therapy
8. Bioartificial kidney under study at MCG
9. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
10. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
11. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... 2017 Summary This report provides ... KGaA and its partnering interests and activities since 2010. ... Description The Partnering Deals and Alliance since 2010 report ... one of the world,s leading life sciences companies. ... to ensure inclusion of the most up to date ...
(Date:3/2/2017)... Australian stem cell and regenerative medicine company, ... an agreement with the Monash Lung Biology Network, a ... and Department of Pharmacology at Monash University, ... to support the use of Cymerus™ mesenchymal stem cells ... Asthma is a chronic, long term lung condition recognised ...
(Date:2/28/2017)... ANGELES , Feb. 28, 2017   Acuant ... verification software globally, announces significant enhancements to new and ... May 2016. New products include mobile and desktop Acuant ... DocX TM - a real time manual review ... core idScan® technology provides the fastest and most accurate ...
Breaking Biology News(10 mins):
(Date:3/22/2017)...  Ascendis Pharma A/S (Nasdaq: ASND), a biopharmaceutical ... address significant unmet medical needs in rare diseases, ... ended December 31, 2016. "2016 ... we broadened our pipeline and pursued our vision ... with an initial focus on endocrinology," said ...
(Date:3/22/2017)... The global chronic kidney disease ... by Transparency Market Research (TMR). The top four players, ... Inc., accounted for a share of only 41.4% in ... market are focusing aggressively on mergers, acquisitions, and strategic ... to lead to market consolidation in the next few ...
(Date:3/22/2017)... ... 21, 2017 , ... Premier executive recruitment firm, Slone Partners, is proud to ... Scanlon Media. , Hunt Scanlon Media is one of the most respected ... source in the human capital sector. , “It is a great honor for Slone ...
(Date:3/22/2017)... ... March 21, 2017 , ... The Conference Forum has announced the launch ... held on May 10-11, 2017, at the Colonnade Hotel in Boston, MA. The CMO ... Officer peer-to-peer learning, benchmarking and support. , “The Chief Medical Officer faces a unique ...
Breaking Biology Technology: