Navigation Links
KaloBios Announces Preliminary Phase 1 Results in Advanced Hematologic Malignancies with KB004, an Anti-EphA3 Monoclonal Antibody
Date:12/10/2013

SOUTH SAN FRANCISCO, Calif., Dec. 10, 2013 /PRNewswire/ -- KaloBios Pharmaceuticals, Inc. (Nasdaq: KBIO) today announced preliminary results of an ongoing multi-center Phase 1 study of KB004, an anti-EphA3 monoclonal antibody (mAb), which the company is developing as a treatment for hematologic malignancies. Forty-four patients with refractory disease or who were unfit for chemotherapy have been enrolled in the dose escalation portion of the study.  The experimental patient-targeted therapeutic has been well tolerated, with initial evidence of clinical activity.

(Logo: http://photos.prnewswire.com/prnh/20130225/MM66380LOGO)

Preliminary results of the study were presented yesterday by lead investigator, Jeffrey E. Lancet, M.D. of the H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida at the 55th American Society of Hematology Annual Meeting and Exhibition (ASH), held this week in New Orleans, Louisiana.

"We are encouraged by the results seen with KB004 to date, which has been well-tolerated at doses up to 190 mg, with mild to moderate transient infusion reactions the most common toxicity," said Dr. Lancet. "There are some signs of activity as well, including a patient with relapsed acute myeloid leukemia (AML) who had sustained remission for over 1 year."

Escalating doses of KB004 were administered as a 1 or 2 hour infusion on days 1, 8, and 15 of a 21 day cycle at incremental doses of 20, 40, 70, 100, 140, 190 and 250 mg and will thereafter increase at 33% increments up to a planned maximum of 700 mg. The primary study objective is to determine a maximum tolerated dose, which has not yet been reached. Secondary objectives included evaluation of pharmacokinetics, imm
'/>"/>

SOURCE KaloBios Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology news :

1. KaloBios to Present KB004 Interim Phase 1 Clinical Data in Hematologic Malignancies at ASH
2. Wyss Institute at Harvard University announces election of 2 faculty to Natl Academy of Inventors
3. Reproductive Health Matters announces publication of its latest themed issue: New development paradigm
4. Afterburn Fuel Review Announces the Launch of its New and Informative Website
5. VaxTrac Announces Continued Support for Expansion of Biometric-based Mobile Vaccine Registry Programs in Benin
6. AIBS announces winners of Faces of Biology photo competition
7. NERC announces the winner of its first photo and essay competition
8. Elsevier announces the launch of open access journal: Current Plant Biology
9. AVS Announces Its Major Award Winners of 2013
10. The Association for Molecular Pathology announces highlights of Phoenix meeting
11. EMBO announces the launch of EMBO Press
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... BETHESDA, Md. , April 2, 2015 ... Salt Lake City , the American ... election of five new directors to its Board.  Members ... for the ACMG and for forming and advancing its ... the medical genetics profession. "It,s an eventful ...
(Date:3/31/2015)... -- Elephant Talk Communications Corp. (NYSE MKT: ETAK) ("Elephant Talk" ... Network Architecture (ET Software DNA® 2.0) platforms and cyber ... million for the year ended December 31, 2014 as ... ended December 31, 2013. At the ... multi-year transition away from its legacy landline business to ...
(Date:3/24/2015)... 24, 2015 Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) ... - Global Strategic Business Report" report to their offering. ... Biometrics in US$ Thousands by the following Segments: Face Biometrics, and ... Canada , Japan , ... Middle East & Africa , and ...
Breaking Biology News(10 mins):American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6
... PULLMAN, Wash. - Washington State University researchers have taken ... decoding the specific brain circuits involved in depression. By ... primary emotions, graduate student Jason Wright and his advisor ... associated with a depressed, negative mood, or affect. ...
... waters could compromise the ability of oysters and other ... to a new study led by University of Georgia ... November 2011 issue of Nature Geoscience . The ... by the Mississippi River to the northern Gulf of ...
... recent election, 21 new Fellows were inducted into ... Sunday, Oct.23, at ceremonies that followed the opening ... and Health Informatics, where about 2,500 informatics professionals ... sessions, and educational panels on topics including data ...
Cached Biology News:WSU researchers demonstrate rare animal model for studying depression 2Run-off, emissions deliver double whammy to coastal marine creatures, UGA study finds 221 Fellows inducted into American College of Medical Informatics 2
(Date:4/28/2015)... Reproductive endocrinologist Dr. Kaylen Silverberg , on the ... in this country, testified on behalf of House Bill ... in the nation to consider creating a clearinghouse to connect ... to receive them. , Infertility affects over 7.3 million couples ... of the few medical diseases that is curable, the treatment ...
(Date:4/27/2015)... 27, 2015 /PRNewswire/ - iCo Therapeutics ("iCo" or "the ... results for the year ended December 31, 2014. ... dollars and presented under International Financial Reporting Standards ... results did not provide the outcome management and ... remain at iCo Therapeutics", said Andrew Rae ...
(Date:4/27/2015)...  Edico Genome today announced that collaborative data ... Stanford Universities showed the DRAGEN™ Bio-IT Processor sped ... depth of coverage by tenfold, generating results in ... standard software. "Processing large amounts of ... research and clinical labs, in terms of the ...
(Date:4/27/2015)... , April 27, 2015 ... this release, please scroll to bottom . ... equities: Lexicon Pharmaceuticals Inc. (NASDAQ: LXRX ), ... Pharmaceuticals Corporation (NASDAQ: SNTA ), Spectrum Pharmaceuticals ... (NASDAQ: MDVN ). Free research report on ...
Breaking Biology Technology:Texas Fertility Center Supports a Groundbreaking HB1145 that Facilitates Embryo Donation in Texas 2Texas Fertility Center Supports a Groundbreaking HB1145 that Facilitates Embryo Donation in Texas 3iCo Therapeutics Announces Year End 2014 Financial Results 2iCo Therapeutics Announces Year End 2014 Financial Results 3iCo Therapeutics Announces Year End 2014 Financial Results 4Edico Genome, in Collaboration with Researchers from Harvard and Stanford Universities, Speeds Analysis of Whole Genome Sequence with 300x Depth of Coverage Tenfold 2Edico Genome, in Collaboration with Researchers from Harvard and Stanford Universities, Speeds Analysis of Whole Genome Sequence with 300x Depth of Coverage Tenfold 3Market Updates on Biotech Stocks -- Lexicon Pharma, Idera Pharma, Synta Pharma, Spectrum Pharma, and Medivation 2Market Updates on Biotech Stocks -- Lexicon Pharma, Idera Pharma, Synta Pharma, Spectrum Pharma, and Medivation 3Market Updates on Biotech Stocks -- Lexicon Pharma, Idera Pharma, Synta Pharma, Spectrum Pharma, and Medivation 4Market Updates on Biotech Stocks -- Lexicon Pharma, Idera Pharma, Synta Pharma, Spectrum Pharma, and Medivation 5
... Receives NHPD/Health Canada Authorization to Begin a Study on, ... (Immunocal(R)) in, Combination with Physical Exercise on ... Levels in Elderly Persons: A Randomized, Double-Blind ... Inc. (TSX-V: IMM) announced today that the Natural Health Products ...
... the ninth consecutive year, internationally acclaimed celebrities will come ... http://starkeyhearingfoundation.org ), , the global leader in ... its mission of providing hearing instruments to underprivileged children ... will gather for the Foundation,s annual "So the World ...
... 7 OncoMed Pharmaceuticals, Inc., a clinical-stage company developing ... announced the appointment of Sunil Patel to the position ... new position, Mr. Patel will have primary responsibility for ... OncoMed,s President and Chief Executive Officer. , , ...
Cached Biology Technology:2009: Immunotec announces important clinical research initiative: New study to be launched with the goal of improving the quality of the aging process 22009: Immunotec announces important clinical research initiative: New study to be launched with the goal of improving the quality of the aging process 3Celebrities to Gather to Support the Ninth Annual Starkey Hearing Foundation 'So the World May Hear' Awards Gala 2Celebrities to Gather to Support the Ninth Annual Starkey Hearing Foundation 'So the World May Hear' Awards Gala 3OncoMed Pharmaceuticals Appoints Sunil Patel Senior Vice President, Corporate Development 2
... DNA Ligase catalyzes the formation of phosphodiester ... double-stranded DNAs with 3' hydroxyl and 5' ... buffer optimizes ligation which can be performed ... are not substrates for this enzyme. ...
Bovine Renal Artery Smooth Muscle Cells (BRASMC) (>500,000 cells)...
... is a major step forward in ... handling system - with one universal ... modules. All five single channel and ... one handle. The lightweight handle is ...
Sulfadimethoxine (CH-2027)...
Biology Products: