Navigation Links
KIT researchers develop artificial bone marrow
Date:1/10/2014

This news release is available in German.

Artificial bone marrow may be used to reproduce hematopoietic stem cells. A prototype has now been developed by scientists of KIT, the Max Planck Institute for Intelligent Systems, Stuttgart, and Tbingen University. The porous structure possesses essential properties of natural bone marrow and can be used for the reproduction of stem cells at the laboratory. This might facilitate the treatment of leukemia in a few years. The researchers are now presenting their work in the "Biomaterials" journal (DOI: 10.1016/j.biomaterials.2013.10.038).

Blood cells, such as erythrocytes or immune cells, are continuously replaced by new ones supplied by hematopoietic stem cells located in a specialized niche of the bone marrow. Hematopoietic stem cells can be used for the treatment of blood diseases, such as leukemia. The affected cells of the patient are replaced by healthy hematopoietic stem cells of an eligible donor.

However, not every leukemia patient can be treated in this way, as the number of appropriate transplants is not sufficient. This problem might be solved by the reproduction of hematopoietic stem cells. So far, this has been impossible, as these cells retain their stem cell properties in their natural environment only, i.e. in their niche of the bone marrow. Outside of this niche, the properties are modified. Stem cell reproduction therefore requires an environment similar to the stem cell niche in the bone marrow.

The stem cell niche is a complex microscopic environment having specific properties. The relevant areas in the bone are highly porous and similar to a sponge. This three-dimensional environment does not only accommodate bone cells and hematopoietic stem cells but also various other cell types with which signal substances are exchanged. Moreover, the space among the cells has a matrix that ensures a certain stability and provides the cells with points to anchor. In the stem cell niche, the cells are also supplied with nutrients and oxygen.

The Young Investigators Group "Stem CellMaterial Interactions" headed by Dr. Cornelia Lee-Thedieck consists of scientists of the KIT Institute of Functional Interfaces (IFG), the Max Planck Institute for Intelligent Systems, Stuttgart, and Tbingen University. It artificially reproduced major properties of natural bone marrow at the laboratory. With the help of synthetic polymers, the scientists created a porous structure simulating the sponge-like structure of the bone in the area of the blood-forming bone marrow. In addition, they added protein building blocks similar to those existing in the matrix of the bone marrow for the cells to anchor. The scientists also inserted other cell types from the stem cell niche into the structure in order to ensure substance exchange.

Then, the researchers introduced hematopoietic stem cells isolated from cord blood into this artificial bone marrow. Subsequent breeding of the cells took several days. Analyses with various methods revealed that the cells really reproduce in the newly developed artificial bone marrow. Compared to standard cell cultivation methods, more stem cells retain their specific properties in the artificial bone marrow.

The newly developed artificial bone marrow that possesses major properties of natural bone marrow can now be used by the scientists to study the interactions between materials and stem cells in detail at the laboratory. This will help to find out how the behavior of stem cells can be influenced and controlled by synthetic materials. This knowledge might contribute to producing an artificial stem cell niche for the specific reproduction of stem cells and the treatment of leukemia in ten to fifteen years from now.


'/>"/>

Contact: Monika Landgraf
presse@kit.edu
49-721-608-47414
Helmholtz Association
Source:Eurekalert  

Related biology news :

1. Researchers pursuing arthritis protein
2. Researchers discover a tumor suppressor gene in a very aggressive lung cancer
3. Researchers unveil rich world of fish biofluorescence
4. Researchers propose alternative way to allocate science funding
5. New organization brings together top researchers to sequence the genomes of invertebrates
6. Plan to delist gray wolf endangers other threatened species, researchers find
7. Researchers say fructose does not impact emerging indicator for cardiovascular disease
8. Researchers complete a milestone in defining the genetic basis of rheumatoid arthritis
9. Researchers create largest evolutionary timetree of land plants to investigate traits that permit survival in cold climates
10. Penn researchers grow liquid crystal flowers that can be used as lenses
11. UT Southwestern neuroscience researchers identify gene involved in response to cocaine
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
KIT researchers develop artificial bone marrow
(Date:12/15/2016)... LONDON , Dec. 15, 2016 /PRNewswire/ ... the driving experience, health wellness and wellbeing ... As one in three new passenger vehicles ... voice recognition, gesture recognition, heart beat monitoring, ... eyelid monitoring, facial monitoring, and pulse detection. ...
(Date:12/8/2016)... 2016 Market Research Future published a half cooked research ... Biometric Security and Service Market is expected to grow over the ... Market Highlights: ... Mobile Biometric Security and Service Market ... need of authentication and security from unwanted cyber threats. The increasing ...
(Date:12/7/2016)...   Avanade is helping Williams Martini Racing, ... history, exploit biometric data in order to critically analyse ... competitive edge against their rivals after their impressive, record-breaking ... has worked with Williams during the 2016 season to ... rate, breathing rate, temperature and peak acceleration) for key ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... 2017  Market Research Future published a half-cooked research report on ... grow at a CAGR of 12% during the period 2016 to ... ... abnormal cell division without any control. These abnormal cells have the ... cancer cells can spread to other parts of the body through ...
(Date:1/17/2017)... N.J. , Jan. 17, 2017 Roka Bioscience, Inc. ... providing advanced testing solutions for the detection of foodborne pathogens today ... CEO.  Ms. Duseau succeeds Paul Thomas , the Company,s President ... of the Company,s Board of Directors.  The changes are effective today. ... of Directors, effective today. ...
(Date:1/17/2017)... 17, 2017  Only nine percent of U.S. consumers ... while only 16 percent believe health insurance companies do, ... 36 percent of U.S. adults believe health care providers ... compared to hospitals (23%). "We are in ... Wendy Salomon , vice president of reputation management and ...
(Date:1/17/2017)... ... January 17, 2017 , ... NeoTrident, ... provider of learning and performance management systems for high-consequence industries, announced today that ... “In the life sciences industry, organizations must pay much more attention to the ...
Breaking Biology Technology: