Navigation Links
KINAXO Biotechnologies and Bayer Vital GmbH Collaborate in Phosphoproteomics Biomarker Identification
Date:10/15/2009

Martinsried, Leverkusen, Germany, October 15, 2009 / b3c newswire / - KINAXO Biotechnologies GmbH and Bayer Vital GmbH announced today that they will enter into collaboration. KINAXO will apply its quantitative phosphoproteomics technology PhosphoScout for the identification of novel biomarkers in a clinical trial conducted by Bayer Vital.

KINAXOs phosphoproteomics platform allows annotation and quantification of regulated phosphorylation sites. Since the majority of targeted compounds used as anti-cancer drugs influence cellular signal transduction pathways, analysis of phosphorylation patterns in relation to drug administration reveals a compounds molecular mode of action. Characteristic phosphorylation sites predicting response to treatment, resistance mechanism or synergistic effects can hereby be identified as biomarkers which allow for personalized treatment plans.

Accompanying a clinical trial for the multi-kinase inhibitor Nexavar in Acute Myeloid Leukemia (AML), KINAXO will apply its phosphoproteomics technology to reveal the drugs influence on cellular phosphorylation patterns and to search for novel predictive biomarkers. Nexavar is already approved for the treatment of hepatocellular (HCC) and renal cell carcinoma (RCC) and shows promising effects in several other indications, amongst them AML, the most common type of leukemia in adults. Despite considerable efforts over the last decades, therapeutic outcome in AML therapy has improved only modestly and remains dismal, with a high number of patients being non-responsive to standard treatment or recurrent. Application of KINAXOs phosphoproteomics technology could thus turn out to be a valuable tool to discover predictive biomarkers that foretell therapeutic outcome in patients. Furthermore, quantitative phosphoproteomics will be applied to investigate the molecular efficiency of potential combination therapies in which Nexavar will be administered together with other targeted drugs
'/>"/>

b3c newswire

Page: 1 2 3 4

Related biology news :

1. KINAXOs Cellular Target Profiling reveals mTOR as a new target of Celebrex
2. KINAXO launches KinAffinity services for efficient profiling of kinase inhibitors in cells or tissue
3. VIB and Bayer join forces for plant research
4. Ben-Gurion University of the Negev signs collaborative contract with Bayer CropScience
5. ERS-2 data vital for maritime security
6. New discovery on role of vital protein that fights meningitis
7. Gap junction protein vital to successful pregnancy, researchers find
8. Herbicide-resistant grape could revitalize Midwest wine industry
9. Loggerhead release to provide vital information to scientific community
10. Researchers first to see reactive oxygen species in vital enzyme
11. Understanding phosphorus in soils is vital to proper management
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... two different ways that allow unprecedented experimental insights ... of oxygen molecules in photosynthesis. The two studies ... Nature Communications . , "The new knowledge will ... oxidation, which are key components for building artificial ... energy in fuels like hydrogen, ethanol or methanol," ...
(Date:7/11/2014)... normal circumstances, astrocytes participate in normal physiological ... exhibit therapeutic and repairing effects on brain ... found that nerve cells differentiated from adipose-derived ... viability, which produces influences on subsequent studies ... Hospital, Hebei United University, China demonstrated that ...
(Date:7/10/2014)... and other major cities in New Mexico, nearly every ... wastewater rather than precious potable water supplies. Across the ... all golf courses receive treated effluent. Reusing the effluent ... golf courses and homeowners alike fertilize their lawns during ... nitrate. A New Mexico State University turfgrass expert has ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2'Tailored' water -- the latest in lawn care 2
... A team of scientists from The Scripps Research ... the deadliest antibiotic-resistant bacteria. The compound could one day ... highly resistant bacterial infections. The results were published ... of the American Chemical Society . "[These results] ...
... AURORA, Colo. (Aug. 24, 2011) A scientist investigating why ... coordination has found that key eye reflexes are substantially altered. ... researcher Alberto Costa, MD, Ph.D., could lead to new tools ... at improving quality of life for those with this genetic ...
... The delivery system for an important class of proteins ... mere three components, according to a new study. ... percent of the membrane proteins in a cell, are known ... membrane after construction. New research from the University of Chicago ...
Cached Biology News:Scientists reengineer antibiotic to overcome dangerous antibiotic-resistant bacteria 2Scientists reengineer antibiotic to overcome dangerous antibiotic-resistant bacteria 3Scientists reengineer antibiotic to overcome dangerous antibiotic-resistant bacteria 4Researcher finds altered cerebella in those with Down syndrome 2Three-part handoff delivers proteins to membrane surface 2Three-part handoff delivers proteins to membrane surface 3
(Date:7/10/2014)... Senior supply chain management executives from ... the challenges of “Reducing Cost, Lead Time, & Defects ... sourcing. Describing the partnership of the Bio Supply Management ... Institute ( SCMI) of the University of San ... the Kroc Institute of Peace and Justice in San ...
(Date:7/10/2014)... 2014 /PRNewswire-iReach/ -- Tute Genomics, the leader ... an agreement with Lineagen, Inc., to provide ... Dx PLUS.  Lineagen, focused on the ... currently offers FirstStep Dx PLUS, a ... by healthcare providers as a first-line genetic ...
(Date:7/10/2014)... in the fight against terrorism with the creation of ... with the use of light and special glass fibres. ... B: Chemical , the researchers describe a novel optical ... low as 6.3 ppm (parts per million). It requires ... "Traditionally explosives detection has involved looking for metals that ...
(Date:7/10/2014)... quantum Hall effect in bilayer graphene and shown that ... an electric field. , The fractional quantum Hall ... sheets are exposed to large magnetic fields, is a ... electrons behave as a single system. However, while the ... details of this collective behavior remain not well understood, ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Detecting trace amounts of explosives with light 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3
... August 5 ,Amsterdam Molecular Therapeutics (Euronext: AMT), a ... announced that it will release its financial,results for ... August 13, 2008 at,noon Central European Time (CET). ... conference call at 2:00 p.m. CET. Netherlands dial ...
... DIEGO, Aug. 4 Cadence Pharmaceuticals,Inc. (Nasdaq: ... and commercializing proprietary product candidates principally,for use in ... and CEO Theodore Schroeder will present the company,s ... -- Bank of America,s 2008 Specialty Pharmaceuticals Conference ...
... MDVN ) today announced that it will host a ... progress and provide,a general business update on Monday, August ... press release for the second quarter ended June,30, 2008 ... 2008., Interested parties may call 877-397-0286 from the ...
Cached Biology Technology:Cadence Pharmaceuticals' CEO Theodore Schroeder to Present at Two Investment Conferences During the Month of August 2008 2
... Anti-PRK2 MW 140kDa ... Immunogen Peptide spanning amino acids ... Purification immunoaffinity purified Quality ... RIPA lysates from HeLa cells. ...
...
Replacement Parts for Electrophoresis Apparatus...
Sprague-Dawley rats, 7-8 weeks old, mixed gender; tissue is collected fresh, frozen on dry ice within minutes of sacrifice and stored at -20C; individual tissue weight approx. 0.05 gram....
Biology Products: