Navigation Links
K-State researchers help Epitopix license the United States' first E. coli O157 vaccine for cattle
Date:3/13/2009

Studies by veterinary researchers at Kansas State University, with collaboration from Epitopix LLC, have resulted in the United States' first vaccine against E. coli O157 in beef cattle.

"Researchers have done so much to focus on the post-harvest food safety aspect, whether it's E. coli or salmonella," said Dan Thomson of K-State's College of Veterinary Medicine. Thomson is the Jones Professor of Production Medicine and Epidemiology in the department of clinical sciences.

"Controlling foodborne pathogen outbreaks, and specifically E. coli O157, has been a major research initiative of many government and private agencies for the last two decades," he said. "We're really excited about the potential of this vaccine to aid pre-harvest food safety in beef cattle."

Thomson led both challenge studies and field studies to help the vaccine garner approval from the U.S. Department of Agriculture. It was developed by researchers Daryll Emery, Darren Straub and Doug Burkhardt of Epitopix LLC in Willmar, Minn. Thomson collaborated with T.G. Nagaraja, university distinguished professor of diagnostic medicine and pathobiology at K-State, and Guy Loneragan of West Texas A&M University.

"We're excited that this vaccine has been granted a conditional approval by the U.S. Department of Agriculture," Thomson said. "We have been a research collaborator for Epitopix to conduct the work that lead to this conditional approval. Epitopix will now be able to offer this pre-harvest food safety tool to beef producers."

The researchers conducted a challenge study at K-State and studies of commercial feed yards in Nebraska and Great Bend in 2007 and 2008.

"With this vaccine, we observed decreases in cattle shedding E. coli O157," Thomson said. "In our last field study we observed an 86 percent reduction in the number of animals shedding E. coli. Of the vaccinated cattle that were still shedding, we observed nearly a 98 percent reduction of E. coli O157 fecal concentration.

"Epitopix LLC has had many successes with this technology in other industries including poultry and dairy," Thomson said. "They have a product currently on the market for control of Salmonella in dairy cows."

E. coli, like other foodborne pathogens, is a bacteria that is present in the gastrointestinal tract of healthy cattle. Foodborne pathogens can contaminate meat or vegetable products. If food isn't properly cooked, the bacteria can harm the people who eat it. More information on proper ways to cook meat is available at: http://www.oznet.ksu.edu/news/sty/2001/2meat1a.htm

Thomson said the vaccine works by not allowing the E. coli bacteria to acquire iron. Instead of targeting the whole bacterium, this vaccine targets certain proteins and protein receptors on the surface on the bacteria. When antibodies block these proteins and protein receptors, the bacteria can't absorb iron and are not able to grow or reproduce.

"Iron is to bacteria what oxygen is to humans," he said.

Thomson said K-State appreciates the research partnership with Epitopix on this important pre-harvest food safety tool and that the partnership allowed several K-State graduate students to participate in the study. They included Trent Fox, a December 2007 doctoral graduate in pathobiology and now a third-year veterinary medicine student, St. John; Ashley Thornton, a December 2007 master's degree graduate in biomedical science, St. Joseph, Mo.; and Ben Wileman, a doctoral student in pathobiology, Belle Fourche, S.D.

Thomson said the next step for the K-State researchers is to conduct post-approval studies on the vaccine by looking at its effects on cow herds at the ranch before the calves arrive at the feed yards. This includes studying whether cows can pass the resistance on to their calves.


'/>"/>

Contact: Dan Thomson
dthomson@vet.k-state.edu
785-532-4890
Kansas State University
Source:Eurekalert

Related biology news :

1. K-State Veterinary Lab routinely tests for bluetongue virus
2. K-State chemistry professor to receive Masao Horiba award
3. K-State sociologists use Department of Energy grant
4. K-State researchers findings on E. coli
5. K-State specialist in tick-borne pathogens receives $1.8 million grant
6. K-State contributions to red flour beetle genome sequencing featured in March 27 issue of Nature
7. Rapid test for pathogens developed by K-State researchers
8. K-State professors USDA research shows mad cow disease also caused by genetic mutation
9. K-State research: Freshwater pollution costs US at least $4.3 billion a year
10. Researchers to use K-States BSL-3 Lab for $1 million study of fungus threatening wheat crops
11. K-State biologist collaborating with researchers in Africa on grassland sustainability, biodiversity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2016)... -- The rising popularity of mobility services such ... significant interest in keyless access systems. Following the ... (BLE), biometrics and near-field communication (NFC) are poised ... technologies in the automotive industry. This evolution from ... opens the market to specialist companies such as ...
(Date:12/16/2016)... Dec. 16, 2016   IdentyTechSolutions America LLC ... products and solutions and a cutting-edge manufacturer of ... it is offering seamless, integrated solutions that comprise ... products. The solutions provide IdentyTech,s customers with combined ... facilities from crime and theft. "We ...
(Date:12/15/2016)... VANCOUVER, Canada and BADEN-BADEN, Germany ... Solutions, a leading global financial services provider, today announced an ... in passive behavioural biometrics, to join forces. The partnership will ... fraud mitigation strategies in compliance with local data protection regulation. ... In ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... ... 12, 2017 , ... MEXICO’S FIRST SPINAL ... announces the successful outcome of the first lumbar fusion procedure in Mexico ... Inc.) has partnered with Mexico-based medical product company BioMedical Technologies to bring ...
(Date:1/12/2017)... , January 12, 2017 The ... world,s biggest facility for producing mycorrhizae. The Centre for ... tapping potential of mycorrhizae and developed a technology that ... ... The TERI facility has a ...
(Date:1/11/2017)... ... January 11, 2017 , ... Phase 1 clinical ... promise of the investigational anti-cancer agent tucatinib (formerly ONT-380) against HER2+ breast cancer. ... Twenty-seven percent of these heavily pretreated patients saw clinical benefit from the drug, ...
(Date:1/11/2017)... ... January 11, 2017 , ... With sepsis ... systems more than $23.7 billion, healthcare systems are looking to provide better ... most common sepsis-causing pathogens are bacteria and the yeast pathogen Candida, which can ...
Breaking Biology Technology: