Navigation Links
K-State research team investigates mutated gene's role in breast cancer
Date:8/9/2010

MANHATTAN, KAN. -- A microscopic gene may play a gigantic role when it comes to cancerous tissue in the human body, according to one Kansas State University research team.

The team is investigating mutation within the ADAM12 gene of the A Disintegrin and Metalloprotease family, or ADAM family, and its role in breast cancer.

"We want to know whether ADAM12 is a good guy or a bad guy in breast cancer," said Anna Zolkiewska, associate professor of biochemistry and research team leader.

If researchers can answer this question about ADAM12, Zolkiewska said it could lead to more effective therapies and treatments due to a better understanding of cancer's components. This, however, hinges on discovering the exact nature of ADAM12, about which little is known. Research has uncovered some interesting information -- and raised more questions, Zolkiewska said.

"Typically human cells have very little ADAM12 protein, but the abundance is suddenly very high in cancer tissue," she said. "When we look even closer, we find a very high level of ADAM12 expression in what we call cancer stem cells. Those cells are the most vicious as they drive the tumor growth."

Although chemotherapy and radiotherapy kill tumors, they are ineffective on the cancer stem cells, Zolkiewska said. Without being surgically removed from the body, the stem cells will grow another tumor over the course of a few years. This again raises the question as to the role of ADAM12.

"Is it helping that tumor re-grow or is it trying to prevent it?" Zolkiewska asks.

Perhaps the most perplexing question the team hopes to solve is why the ADAM12 gene mutates inside cancer tissue.

"Mutation means that one letter in the DNA within the cell has changed," Zolkiewska said. "This is very striking because there are only a handful of human genes that are changed that way in tumors. ADAM12 is one of those genes and the only one among that family."

Zolkiewska said this raises the questions of whether the gene's mutation in cancer tissue is purely a coincidence or is part of a larger role. Prior research by the team indicates ADAM12 is a "good guy" since mutation to the gene effectively kills ADAM12 protein.

"A tumor wants to grow, and from the point of view of the tumor, you want to invade and kill the patient. So you will first take care of those good guys, or those policemen inside the body who protect the patient," Zolkiewska said. "If ADAM12 is one of those good guys, the growing tumor wants to take it out of the picture."

This discovery of mutation rendering ADAM12 dead was a scientific first by the K-State team.

Zolkiewska recently was awarded a three-year grant of $444,000 from the National Institutes of Health to further the research. The grant's title is "Structure-Function Analysis of Breast Cancer-Associated Mutations in ADAM12."

Assisting Zolkiewska in the research are Sara Duhachek Muggy, Manhattan, a graduate student in biochemistry, and Hui Li, who is conducting postdoctoral work. Zolkiewska credited a large portion of the team's findings to Emilia Solomon, Los Alamos, N.M., a December 2009 biochemistry doctoral graduate.


'/>"/>

Contact: Anna Zolkiewska
zolkiea@k-state.edu
785-532-3082
Kansas State University
Source:Eurekalert

Related biology news :

1. K-State research: Freshwater pollution costs US at least $4.3 billion a year
2. Researchers to use K-States BSL-3 Lab for $1 million study of fungus threatening wheat crops
3. K-State biologist collaborating with researchers in Africa on grassland sustainability, biodiversity
4. K-State researchers help Epitopix license the United States first E. coli O157 vaccine for cattle
5. K-State researchers work with university in Ghana to create biofuels from native tree seeds
6. K-State using Second Life island to help high school students learn earth science
7. K-State researcher finds 1918 flu resulted in current lineage of H1N1 swine influenza viruses
8. K-State host to workshop on rapid methods to detect microorganisms in food
9. Researchers from around the globe coming to K-State June 21 for workshop on Fusarium fungus
10. K-State plant pathologists develop online teaching modules used globally
11. K-State researcher, collaborators study virulence of pandemic H1N1 virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/14/2017)...  IBM (NYSE: IBM ) is introducing several innovative ... to developing collaboration between startups and global businesses, taking place ... the event, nine startups will showcase the solutions they have ... France is one ... a 30 percent increase in the number of startups created ...
(Date:5/6/2017)... , May 5, 2017 ... just announced a new breakthrough in biometric authentication ... exploits quantum mechanical properties to perform biometric authentication. These ... smart semiconductor material created by Ram Group and ... finance, entertainment, transportation, supply chains and security. Ram ...
(Date:4/17/2017)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... 2016 Annual Report on Form 10-K on Thursday April 13, 2017 ... ... Investor Relations section of the Company,s website at http://www.nxt-id.com  under ... http://www.sec.gov . 2016 Year Highlights: ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... ... , ... While art and science are often thought of as two completely ... A Mesh Is Also a Snare, a group exhibition presented by the Philadelphia-based ... Gallery (EKG) on August 17 and run through September 30. An opening reception will ...
(Date:8/16/2017)... ... August 16, 2017 , ... We are ... Administration (FDA) inspection at our Dilworth, MN site. The inspection took place Monday, ... was conducted as part of a routine Bioresearch Monitoring Program (BIMO) with the ...
(Date:8/16/2017)... OXFORD, England , Aug. 16, 2017  Kingfisher Talent, ... search and leadership development, and Virdis Group, global executive search ... exclusive alliance that enables clients to leverage the expertise and ... "For our clients here in the Boston ... diverse population of leadership talent throughout the US, ...
(Date:8/15/2017)... ... ... Kapstone Medical is proud to announce that it has reached a ... develop and safeguard their latest innovations. The company has grown from a boutique ... in the United States and around the world. , Company Founder and President, ...
Breaking Biology Technology: