Navigation Links
K-State research team investigates mutated gene's role in breast cancer
Date:8/9/2010

MANHATTAN, KAN. -- A microscopic gene may play a gigantic role when it comes to cancerous tissue in the human body, according to one Kansas State University research team.

The team is investigating mutation within the ADAM12 gene of the A Disintegrin and Metalloprotease family, or ADAM family, and its role in breast cancer.

"We want to know whether ADAM12 is a good guy or a bad guy in breast cancer," said Anna Zolkiewska, associate professor of biochemistry and research team leader.

If researchers can answer this question about ADAM12, Zolkiewska said it could lead to more effective therapies and treatments due to a better understanding of cancer's components. This, however, hinges on discovering the exact nature of ADAM12, about which little is known. Research has uncovered some interesting information -- and raised more questions, Zolkiewska said.

"Typically human cells have very little ADAM12 protein, but the abundance is suddenly very high in cancer tissue," she said. "When we look even closer, we find a very high level of ADAM12 expression in what we call cancer stem cells. Those cells are the most vicious as they drive the tumor growth."

Although chemotherapy and radiotherapy kill tumors, they are ineffective on the cancer stem cells, Zolkiewska said. Without being surgically removed from the body, the stem cells will grow another tumor over the course of a few years. This again raises the question as to the role of ADAM12.

"Is it helping that tumor re-grow or is it trying to prevent it?" Zolkiewska asks.

Perhaps the most perplexing question the team hopes to solve is why the ADAM12 gene mutates inside cancer tissue.

"Mutation means that one letter in the DNA within the cell has changed," Zolkiewska said. "This is very striking because there are only a handful of human genes that are changed that way in tumors. ADAM12 is one of those genes and the only one among that family."

'/>"/>
Contact: Anna Zolkiewska
zolkiea@k-state.edu
785-532-3082
Kansas State University
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. K-State research: Freshwater pollution costs US at least $4.3 billion a year
2. Researchers to use K-States BSL-3 Lab for $1 million study of fungus threatening wheat crops
3. K-State biologist collaborating with researchers in Africa on grassland sustainability, biodiversity
4. K-State researchers help Epitopix license the United States first E. coli O157 vaccine for cattle
5. K-State researchers work with university in Ghana to create biofuels from native tree seeds
6. K-State using Second Life island to help high school students learn earth science
7. K-State researcher finds 1918 flu resulted in current lineage of H1N1 swine influenza viruses
8. K-State host to workshop on rapid methods to detect microorganisms in food
9. Researchers from around the globe coming to K-State June 21 for workshop on Fusarium fungus
10. K-State plant pathologists develop online teaching modules used globally
11. K-State researcher, collaborators study virulence of pandemic H1N1 virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... pneumophila bacteria is responsible for legionellosis, an infectious ... infect us, this pathogen has developed a complex method ... our cells, thus avoiding these acting against the infectious ... centre, CIC bioGUNE, in which teams from the National ... National Supercomputation Centre in Barcelona (BSC) have also participated, ...
(Date:5/22/2013)... screening for prostate cancer could become as easy for ... to UC Irvine research published today in the ... more than a decade of work, UC Irvine chemists ... markers for prostate cancer in urine, meaning that the ... and at dramatically lower cost. The same technology could ...
(Date:5/22/2013)... May 22, 2013. Plastic additives known as phthalates ... everywhere: They turn up in flooring, plastic cups, ... the Centers for Disease Control and Preventionthe bodies ... have come under increasing scrutiny. A growing collection ... can leech from packaging and mix with food) ...
Breaking Biology News(10 mins):Mechanism discovered which aids Legionella to camouflage itself in the organism 2UCI chemists devise inexpensive, accurate way to detect prostate cancer 2UCI chemists devise inexpensive, accurate way to detect prostate cancer 3Study links chemicals widely found in plastics and processed food to elevated blood pressure in children and teens 2
... Information System will provide valuable information for assessing environmental ... Environmental Health Sciences (NIEHS), one of the National Institutes ... up-to-date data to public health and safety workers on ... well as demographic information for local populations. ...
... million from the Grand Challenges in Global health initiative ... to humans to aid in testing the safety and ... & Melinda Gates Foundation, the Yale project will be ... Chair of Immunobiology at Yale University School of Medicine, ...
... A new website with a Global Information System will ... Hurricane Katrina. The National Institute of Environmental Health Sciences ... the website to provide the most up-to-date data to ... waters, infrastructure and industry maps, as well as demographic ...
Cached Biology News:FDA approves child-friendly AIDS medicine 2Grand Challenges in Global Health initiative funds Yale project 2NIEHS launches website with information for assessing environmental hazards from Hurricane Katrina 2
(Date:5/21/2013)... 21, 2013 Savoury Systems International (SSI), ... Dale Braddy to Southeastern USA Sales Broker. Braddy’s new ... muscle in the Southeast. , In 2004 ... and supplier to food processors and industrial manufacturers. ... the food industry and has over 25 years of ...
(Date:5/21/2013)... May 21, 2013 Smarter Security, Inc., ... solutions, today announced that Genzyme, a Sanofi company and ... Door Detective® CL for a multi-use facility in the ... four other Genzyme buildings, this latest order underscores the ... tailgate detection device improving doorway access control. ...
(Date:5/21/2013)... As the R&D sector becomes ... the industry to deliver better products, faster. Collaborations ... companies often means turning big ideas into reality, ... collaboration with Sensidose AB and Recipharm, is one ... to market sooner. The partnership resulted in the ...
(Date:5/21/2013)... Emerson Resources Inc. , a premier pharmaceutical ... Company’s Chief Executive Officer and Chairman of the Board, ... service. As part of Emerson Resources’ planned leadership succession ... as Dr. Signorino’s successor. , Dr. Signorino is ... a significant contribution to the field during his extensive ...
Breaking Biology Technology:Door Security at Genzyme, a Sanofi Company, Enhanced with Door Detective from Smarter Security 2Door Security at Genzyme, a Sanofi Company, Enhanced with Door Detective from Smarter Security 3The Development of an Innovative Microtablet Dosage Form, a Success Story: Live Webinar Hosted by Xtalks 2Emerson Resources Announces CEO Retirement and Appointment of Successor 2Emerson Resources Announces CEO Retirement and Appointment of Successor 3
... , MISSISSAUGA, ON, Oct. 29 /PRNewswire-FirstCall/ - YM BioSciences ... life sciences product development company that identifies and advances ... stages of development, today reported additional results from a ... diffuse intrinsic pontine glioma (DIPG). The updates to the ...
... , - Influenza: 50/50 joint venture agreement signed ... and pandemic flu, manufacturing facility, ... - Thrombolytic: Nears licensing and sales of KINLYTIC(TM) thrombolytic, ... 25% of the dairy semen collection centres now under, ...
... Reportlinker.com announces that a new ... its catalogue. , Worldwide ... Electron Microscope Market Shares, Strategies, and ... , http://www.reportlinker.com/p0153912/Worldwide-Optical-Transmission-TEM-and-Scanning-SEM-Electron-Microscope-Market-Shares-Strategies-and-Forecasts-2009-to-2015.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=prnewswire ...
Cached Biology Technology:YM BIOSCIENCES REPORTS ADDITIONAL RESULTS FROM NIMOTUZUMAB PHASE III STUDY IN CHILDREN WITH GLIOMA PRESENTED BY ONCOSCIENCE AG 2YM BIOSCIENCES REPORTS ADDITIONAL RESULTS FROM NIMOTUZUMAB PHASE III STUDY IN CHILDREN WITH GLIOMA PRESENTED BY ONCOSCIENCE AG 3YM BIOSCIENCES REPORTS ADDITIONAL RESULTS FROM NIMOTUZUMAB PHASE III STUDY IN CHILDREN WITH GLIOMA PRESENTED BY ONCOSCIENCE AG 4Microbix Biosystems Provides a Corporate Update 2Microbix Biosystems Provides a Corporate Update 3Microbix Biosystems Provides a Corporate Update 4Microbix Biosystems Provides a Corporate Update 5Microbix Biosystems Provides a Corporate Update 6Microbix Biosystems Provides a Corporate Update 7Reportlinker Adds Worldwide Optical, Transmission TEM, and Scanning SEM Electron Microscope Market Shares, Strategies, and Forecasts, 2009 to 2015 2Reportlinker Adds Worldwide Optical, Transmission TEM, and Scanning SEM Electron Microscope Market Shares, Strategies, and Forecasts, 2009 to 2015 3Reportlinker Adds Worldwide Optical, Transmission TEM, and Scanning SEM Electron Microscope Market Shares, Strategies, and Forecasts, 2009 to 2015 4Reportlinker Adds Worldwide Optical, Transmission TEM, and Scanning SEM Electron Microscope Market Shares, Strategies, and Forecasts, 2009 to 2015 5
Sheep polyclonal to Salmonella Shoreditch ( Abpromise for all tested applications). Antigen: Native Salmonella shoreditch (Group D2)....
Sheep polyclonal to Salmonella Thomasville ( Abpromise for all tested applications). Antigen: Native Salmonella thomasville...
anti-achaete...
... Oct6 ( Abpromise for all tested applications). ... to KLH derived from within residues 1 - ... acid sequence is proprietary) (Peptide ... Entrez Gene ID: 5453 ...
Biology Products: