Navigation Links
K-State professor's USDA research shows mad cow disease also caused by genetic mutation

MANHATTAN, KAN. -- New findings about the causes of mad cow disease show that sometimes it may be genetic.

"We now know it's also in the genes of cattle," said Juergen A. Richt, Regents Distinguished Professor of Diagnostic Medicine and Pathobiology at Kansas State University's College of Veterinary Medicine.

Until several years ago, Richt said, it was thought that the cattle prion disease bovine spongiform encephalopathy -- also called BSE or mad cow disease -- was a foodborne disease. But his team's new findings suggest that mad cow disease also is caused by a genetic mutation within a gene called Prion Protein Gene. Prion proteins are proteins expressed abundantly in the brain and immune cells of mammals.

The research shows, for the first time, that a 10-year-old cow from Alabama with an atypical form of bovine spongiform encephalopathy had the same type of prion protein gene mutation as found in human patients with the genetic form of Creutzfeldt-Jakob disease, also called genetic CJD for short. Besides having a genetic origin, other human forms of prion diseases can be sporadic, as in sporadic CJD, as well as foodborne. That is, they are contracted when people eat products contaminated with mad cow disease. This form of Creutzfeldt-Jakob disease is called variant CJD.

"Our findings that there is a genetic component to BSE are significant because they tell you we can have this disease everywhere in the world, even in so-called BSE-free countries," Richt said.

An article by Richt and colleague Mark Hall of the National Veterinary Services Laboratories in Ames, Iowa, was published online in the journal PLoS Pathogens. Richt conducted the research while working at the National Animal Disease Center operated in Ames, Iowa, by the U.S. Department of Agriculture's Agricultural Research Service.

Richt said that prion diseases including mad cow disease are referred to as "slow diseases."

"It's a slow process for infectious prion proteins to develop," he said. "That's why the disease takes a long time -- as long as several years -- to show up."

Richt said mad cow disease caused by genetics is extremely rare. A recent epidemiological study estimated that the mutation affects less than 1 in 2,000 cattle. The study was done in collaboration with the U.S. Department of Agriculture-U.S. Meat Animal Research Center in Clay Center, Neb., which is operated by the Agricultural Research Service.

Richt said the upside of knowing that mad cow disease has a genetic component is that it offers ways of stamping out the disease through selective breeding and culling of genetically affected animals. Therefore, Richt and his colleagues developed high throughput assays to offer the possibility for genetic surveillance of cattle for this rare pathogenic mutation.

"Genetic BSE we can combat," Richt said. "We have submitted a patent for a test system that can assess all bulls and cows before they're bred to see whether they have this mutation."


Contact: Juergen A. Richt
Kansas State University

Related biology news :

1. K-State Veterinary Lab routinely tests for bluetongue virus
2. K-State chemistry professor to receive Masao Horiba award
3. K-State sociologists use Department of Energy grant
4. K-State researchers findings on E. coli
5. K-State specialist in tick-borne pathogens receives $1.8 million grant
6. K-State contributions to red flour beetle genome sequencing featured in March 27 issue of Nature
7. Rapid test for pathogens developed by K-State researchers
8. LSU professors work to improve efficiency of ethanol fuel
9. Research shows skeleton to be endocrine organ
10. Newly created cancer stem cells could aid breast cancer research
11. Dominant cholesterol-metabolism ideas challenged by new research
Post Your Comments:
Related Image:
K-State professor's USDA research shows mad cow disease also caused by genetic mutation
(Date:5/12/2016)... , a brand of Troubadour Research & ... Q1 wave of its quarterly wearables survey. A particular ... a program where they would receive discounts for sharing ... "We were surprised to see that so many ... CEO of Troubadour Research, "primarily because there are segments ...
(Date:4/28/2016)... , April 28, 2016 First quarter 2016: ... up 966% compared with the first quarter of 2015 ... SEK 589.1 M (loss: 18.8) and the operating margin was 40% ... 0.32) Cash flow from operations was SEK 249.9 M ... revenue guidance is unchanged, SEK 7,000-8,500 M. The operating ...
(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... June 24, 2016 Epic Sciences unveiled ... cancers susceptible to PARP inhibitors by targeting homologous ... (CTCs). The new test has already been incorporated ... multiple cancer types. Over 230 clinical ... response pathways, including PARP, ATM, ATR, DNA-PK and ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Researchers at ... most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the ... read it now. , Diagnostic biomarkers are signposts in the blood, lung fluid ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, one of the ... brand, UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing ... to its list of well-respected retailers. This list includes such fine stores as ...
(Date:6/23/2016)... 23, 2016 /PRNewswire/ - FACIT has announced the ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or ... of a portfolio of first-in-class WDR5 inhibitors for ... as WDR5 represent an exciting class of therapies, ... medicine for cancer patients. Substantial advances have been ...
Breaking Biology Technology: