Navigation Links
Just like old times: Generating RNA molecules in water
Date:11/20/2009

A key question in the origin of biological molecules like RNA and DNA is how they first came together billions of years ago from simple precursors. Now, in a study appearing in this week's JBC, researchers in Italy have reconstructed one of the earliest evolutionary steps yet: generating long chains of RNA from individual subunits using nothing but warm water.

Many researchers believe that RNA was one of the first biological molecules present, before DNA and proteins; however, there has been little success in recreating the formation on RNA from simple "prebiotic" molecules that likely were present on primordial earth billions of years ago.

Now, Ernesto Di Mauro and colleagues found that ancient molecules called cyclic nucleotides can merge together in water and form polymers over 100 nucleotides long in water ranging from 40-90 C similar to water temperatures on ancient Earth.

Cyclic nucleotides like cyclic-AMP are very similar to the nucleotides that make up individual pieces of DNA or RNA (A, T, G and C), except that they form an extra chemical bond and assume a ring-shaped structure. That extra bond makes cyclic nucleotides more reactive, though, and thus they were able to join together into long chains at a decent rate (about 200 hours to reach 100 nucleotides long).

This finding is exciting as cyclic nucleotides themselves can be easily formed from simple chemicals like formamide, thus making them plausible prebiotic compounds present during primordial times. Thus, this study may be revealing how the first bits of genetic information were created.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Master regulator found for regenerating nerve fibers in live animals
2. NIH funds work at WPI on regenerating heart tissue and preventing urinary tract infections
3. Fat-regenerating stem cells found in mice
4. New synthetic molecules trigger immune response to HIV and prostate cancer
5. Seeing previously invisible molecules for the first time
6. Step forward for nanotechnology: Controlled movement of molecules
7. New nanochemistry technique encases single molecules in microdroplets
8. U-Iowa improves delivery of cancer-fighting molecules
9. Navigating in the ocean of molecules
10. NTU professor discovers method to efficiently produce less toxic drugs using organic molecules
11. Nonstick and laser-safe gold aids laser trapping of biomolecules
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... , May 24, 2016 Ampronix facilitates superior patient care by providing unparalleled ... medical LCD display is the latest premium product recently added to the range of ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/16/2016)... , May 16, 2016   EyeLock LLC , ... announced the opening of an IoT Center of Excellence ... and expand the development of embedded iris biometric applications. ... level of convenience and security with unmatched biometric accuracy, ... identity aside from DNA. EyeLock,s platform uses video technology ...
(Date:5/9/2016)... May 9, 2016 Elevay is ... to expanding freedom for high net worth professionals seeking ... today,s globally connected world, there is still no substitute ... ever duplicate sealing your deal with a firm handshake. ... by taking advantage of citizenship via investment programs like ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created ... services and solutions to the healthcare market. The company's primary focus is on ... sales and marketing strategies that are necessary to help companies efficiently bring their ...
(Date:6/24/2016)... 24, 2016 Epic Sciences unveiled a ... susceptible to PARP inhibitors by targeting homologous recombination ... The new test has already been incorporated into ... cancer types. Over 230 clinical trials ... pathways, including PARP, ATM, ATR, DNA-PK and WEE-1. ...
(Date:6/23/2016)... , June 23, 2016   Boston ... of novel compounds designed to target cancer stemness ... has been granted Orphan Drug Designation from the ... treatment of gastric cancer, including gastroesophageal junction (GEJ) ... inhibitor designed to inhibit cancer stemness pathways by ...
(Date:6/23/2016)... , June 23, 2016  The Prostate Cancer Foundation (PCF) is ... treatments and faster cures for prostate cancer. Members of the Class of 2016 ... countries. Read More About the Class of 2016 PCF ... ... ...
Breaking Biology Technology: