Navigation Links
Just like cars, developmental genes have more than 1 way to stop
Date:2/24/2011

EAST LANSING, Mich. There's more than one way to silence gene activity, according to a Michigan State University researcher.

Downregulating activity is how healthy genes should shift out of their development cycle. The results, published in this week's Current Biology, discuss how specific repressor proteins which researchers have named Hairy and Knirps slow genes during development and how the process is comparable to slowing down a car, says molecular biologist David Arnosti.

The binding of repressor proteins to DNA provides a molecular switch for such regulation. Although the two types of protein have been identified as silencers of gene expression, each one uses a distinct molecular mechanism to halt the process, said Arnosti, director of MSU's Gene Expression in Disease Development initiative.

These mechanisms may hold the keys to explaining how diseases, such as cancer, diabetes and arthritis can be traced to genes that are unable to shift gears properly and can't stop, Arnosti said.

"In automotive terms, a driver can either brake or downshift the transmission to achieve the same result," said Arnosti, who published the paper with Li M. Li, a former MSU doctoral student now working at the University of California, Berkeley. "Similarly, short-range and long-range repressor proteins both interfere with the basic gene expression machinery, but in different ways."

In sequencing the human genome, scientists have assembled a parts list and can point to genes that play a part in disease. Through Li's and Arnosti's research, however, scientists can now begin to see how these genes are regulated through special mechanisms, helping show how an entire organism's genes are controlled.

"Mechanistic studies such as this are giving us the assembly instructions for the genome," Arnosti said. "Basically, it's giving us a way to read genomic control instructions."

Arnosti's research involved fruit fli
'/>"/>

Contact: Layne Cameron
layne.cameron@ur.msu.edu
517-353-8819
Michigan State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Faster CARS, less damage: NIST chemical microscopy shows potential for cell diagnostics
2. Evolution: A Developmental Approach
3. Hard-to-find fish reveals shared developmental toolbox of evolution
4. Developmental biology is focus of new volume in laboratory manual series on imaging
5. The developmental dynamics of the maize leaf transcriptome
6. Developmental gene-environment interactions: A model for psychosis
7. Fertilizer chemicals linked to animal developmental woes
8. Developmental problems: Some exist in the genes
9. Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning
10. Chinese scientists discover marker indicating the developmental potential of stem cells
11. Developmental delay could stem from nicotinic receptor deletion
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... December 9, 2014   ... Platform   Jifflenow, ... scheduling solutions for business-to-business (B2B) events, today announced ... in mobile near-field communication (NFC), Bluetooth low energy ... (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow will integrate ...
(Date:12/3/2014)... Dec. 2, 2014   Marvin Test Solutions ... test solutions for military, aerospace, and manufacturing organizations, ... its successful TS-900 PXI semiconductor test platform ... of high-end systems to customers at a fraction ... to traditional ATE. "Our semiconductor ...
(Date:11/21/2014)... , Nov. 20, 2014 Strict laws ... efficiency are piloting the North American and European automotive ... accidents growing, gesture recognition systems that are intuitive and ... mark in the industry. New analysis ... Gesture Recognition Market in Europe ...
Breaking Biology News(10 mins):Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... Boston, Mass. A computational physicist and a cognitive ... the beginnings of a noninvasive test to evaluate an ... which records electrical activity in the brain, with machine-learning ... percent accuracy in distinguishing between 9-month-old infants known to ...
... cycle, helping sequester significant amounts of carbon. Some algal ... discolor coastal waters and reduce the amount of light ... "red tide," the term "harmful algal blooms" (HABs) was ... biomass can sometimes also turn the ocean waters brown ...
... Cross-disciplinary teams of scientists studying genetic pathways that ... also cause certain forms of congenital heart disease ... muscle that is the leading cause of sudden death ... mutations into mice and successfully treated HCM in the ...
Cached Biology News:Using EEGs to diagnose autism spectrum disorders in infants 2Using EEGs to diagnose autism spectrum disorders in infants 3Brown tide culprit sequenced: Genome of the first of algal bloom species 2Brown tide culprit sequenced: Genome of the first of algal bloom species 3Brown tide culprit sequenced: Genome of the first of algal bloom species 4Cancer-related pathways reveal potential treatment target for congenital heart disease 2Cancer-related pathways reveal potential treatment target for congenital heart disease 3
(Date:12/19/2014)... 19, 2014 Decision Resources Group finds that ... a 12 percent compound annual growth rate through 2023. ... population and the increasing adoption of dental implants. Growing ... will also spur demand for dental biomaterials because they ... periodontal treatments. Other key findings from Decision ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 LayerBio is ... ophthalmology and wound care. The National Eye Institute (NEI) ... LayerBio a Phase I SBIR grant to develop a ... are the most common cause of vision loss in ... blindness worldwide. According to Dr. Ken Mandell, LayerBio’s Founder ...
(Date:12/19/2014)... In contrast to traditional LED lights where the ... uses proprietary LED technology to incorporate their spectra in ... is critical in low proximity installations. The Valoya L-series ... lifetime which is up to four times longer than ... cost was clearly higher when compared to traditional fluorescent ...
(Date:12/19/2014)... , Dec. 18, 2014 Egenix, Inc. is pleased ... elected Chairman of the Board, to succeed Donald Fresne ... but will continue as a member of the Board.  In ... added to the company over almost twenty years, the Board ... Board of Directors has established a Search Committee to find ...
Breaking Biology Technology:Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2
... Corporation (Nasdaq: DNDN ) today announced the ... Association,s (AUA) Annual Meeting in Chicago, as well as ... , ... double-blind, placebo-controlled, multi-center, phase III trial of sipuleucel-T in ...
... April 24 LyondellBasell Industries today announced that ... to Lyondell Chemical Company,s reorganization filing under Chapter ... the European holding company against claims by certain ... AF S.C.A. is a holding company incorporated in ...
... in determining risk for colorectal cancer, the second leading ... Several common genetic markers have been found to be ... that lead to cancer can be much more difficult. ... Research (www.genome.org), scientists have identified a common genetic ...
Cached Biology Technology:Dendreon Announces Data Presentations and Webcast at AUA Annual Meeting 2LyondellBasell Adds Holding Company to Chapter 11 Protection 2Beyond associations: Colorectal cancer culprit found 2
... Microarrays designed for DNA aptamer screening and ... and powerful Paraflo microfluidic on-chip synthesis platform. ... synthesized on-chip and LC Sciences can provide ... are available as part of our comprehensive ...
... (GST) is commonly used as a fusion ... (1). The GSTTag sequence has been reported ... cases the solubility of its fusion partners. ... form, GSTTag fusion proteins can be purified ...
... sequence is from the C-terminal end of the mouse retinoic acid receptor ... 429 to 448 of RAR*. The sequence of PEP-005 is (amino ... - P - S - S - V - E - N ... - P - L - L - Q (The N-terminal cysteine ...
... the next step in the evolution of ... system that delivers labware to multiple laboratory ... times the throughput of ordinary microplate robots. ... variety of configurations to meet any labs ...
Biology Products: