Navigation Links
Just like cars, developmental genes have more than 1 way to stop
Date:2/24/2011

EAST LANSING, Mich. There's more than one way to silence gene activity, according to a Michigan State University researcher.

Downregulating activity is how healthy genes should shift out of their development cycle. The results, published in this week's Current Biology, discuss how specific repressor proteins which researchers have named Hairy and Knirps slow genes during development and how the process is comparable to slowing down a car, says molecular biologist David Arnosti.

The binding of repressor proteins to DNA provides a molecular switch for such regulation. Although the two types of protein have been identified as silencers of gene expression, each one uses a distinct molecular mechanism to halt the process, said Arnosti, director of MSU's Gene Expression in Disease Development initiative.

These mechanisms may hold the keys to explaining how diseases, such as cancer, diabetes and arthritis can be traced to genes that are unable to shift gears properly and can't stop, Arnosti said.

"In automotive terms, a driver can either brake or downshift the transmission to achieve the same result," said Arnosti, who published the paper with Li M. Li, a former MSU doctoral student now working at the University of California, Berkeley. "Similarly, short-range and long-range repressor proteins both interfere with the basic gene expression machinery, but in different ways."

In sequencing the human genome, scientists have assembled a parts list and can point to genes that play a part in disease. Through Li's and Arnosti's research, however, scientists can now begin to see how these genes are regulated through special mechanisms, helping show how an entire organism's genes are controlled.

"Mechanistic studies such as this are giving us the assembly instructions for the genome," Arnosti said. "Basically, it's giving us a way to read genomic control instructions."

Arnosti's research involved fruit fli
'/>"/>

Contact: Layne Cameron
layne.cameron@ur.msu.edu
517-353-8819
Michigan State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Faster CARS, less damage: NIST chemical microscopy shows potential for cell diagnostics
2. Evolution: A Developmental Approach
3. Hard-to-find fish reveals shared developmental toolbox of evolution
4. Developmental biology is focus of new volume in laboratory manual series on imaging
5. The developmental dynamics of the maize leaf transcriptome
6. Developmental gene-environment interactions: A model for psychosis
7. Fertilizer chemicals linked to animal developmental woes
8. Developmental problems: Some exist in the genes
9. Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning
10. Chinese scientists discover marker indicating the developmental potential of stem cells
11. Developmental delay could stem from nicotinic receptor deletion
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... German . ... also provide us with a continuous stream of information about ... sit still in a car the world glides by ... Seemingly without effort, our brain calculates self-motion from this "optic ... a steady gaze during our own movements. Together with biologists ...
(Date:4/17/2014)... available in German . ... protection money demanded of him, he can expect his premises ... as fear of the consequences is enough to make restaurant ... birds, which lay their eggs in other birds, nests. If ... parasites take their revenge by destroying the entire nest. Consequently, ...
(Date:4/17/2014)... painted a stark warning on the possible effects of ... effect 32 times that of carbon dioxide. Now a ... act as fully regenerable electron acceptors which helps explain ... instead of being released to the atmosphere. However, there ... may enter into a vicious cycle to release large ...
Breaking Biology News(10 mins):How vision makes sure that little fish do not get carried away 2How vision makes sure that little fish do not get carried away 3How vision makes sure that little fish do not get carried away 4Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3Methane climate change risk suggested by proof of redox cycling of humic substances 2
... , Simon Fraser University virologist Masahiro Niikura and his doctoral ... that has discovered a new class of molecular compounds capable ... premise that too much of a good thing can be ... manipulating an enzyme that is key to how influenza replicates ...
... specialists at Florida Hospital Pepin Heart Institute and Dr. Kiran ... Florida announced they have enrolled their first patients into a ... of heart failure after ischemic injury. The therapy may ... to deploy more stem cells to the injury site. ...
... THAN SOUM, LAO PDR (February 21, 2012) The Wildlife ... endangered baby Siamese crocodiles into a local wetland in Lao ... The 19-month-old hatchlings, approximately 70 cm (27 inches) in length, ... at the Lao Zoo for eventual release into their native ...
Cached Biology News:Influenza study: Meet virus' new enemy 2New therapy for heart failure may enhance body's stem cell response at cardiovascular injury site 2New therapy for heart failure may enhance body's stem cell response at cardiovascular injury site 319 baby Siamese crocs released in Laos 2
(Date:1/15/2014)... Look inside the new Preferred Solutions® ... lab, from fluid handling to instruments to supplies. Many ... you order. , Preferred Solutions features a full ... L/S® model for precise flow control and dispensing to ...
(Date:1/15/2014)... This webinar will focus on EMA and ... in biosimilars. , Regulatory frameworks are evolving many countries ... the complex nature of biopharmaceuticals makes the demonstration of ... challenging. Based on the specific aspects of biosimilar drug ...
(Date:1/15/2014)... 15, 2014 The Microcompetition with Foreign DNA ... One of these latent viruses is the Epstein Barr Virus ... Rheumatoid arthritis (RA) is a chronic inflammatory disease that destroys ... found that RA patients have high concentrations of EBV DNA ...
(Date:1/15/2014)... Toronto, ON (PRWEB) January 15, 2014 ... an experimental new therapy for the treatment of tinnitus. ... unique tinnitus frequency, and over a period of weeks to ... Notched Sound Therapy in two forms: Notched Music and Notched ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3
... ICLL) today announced that the Australian Therapeutic Goods,Administration ... to,prevent Japanese Encephalitis. This final decision step for ... Australian Drug Evaluation,Committee (ADEC) in December 2008. , ... Australian authorities represents the first,regulatory approval for the ...
... Aerolase Corporation, a leading manufacturer of next-generation portable ... sales increased dramatically in 2008 over 2007. The ... market helped to more than offset current economic ... record sales month for Aerolase, and 2008 overall ...
... Jan. 23 Peter T. Wilderotter, president and CEO ... following statement today in response to FDA clearance of ... is an exciting first step for Geron and for ... to advances in medical research. There has been so ...
Cached Biology Technology:Australian Authorities (TGA) First to Grant Final Product Approval for Intercell's Vaccine to Prevent Japanese Encephalitis 2Australian Authorities (TGA) First to Grant Final Product Approval for Intercell's Vaccine to Prevent Japanese Encephalitis 3Australian Authorities (TGA) First to Grant Final Product Approval for Intercell's Vaccine to Prevent Japanese Encephalitis 4Aerolase Reports Strong Sales in 2008 for Portable Aesthetic Lasers 2Aerolase Reports Strong Sales in 2008 for Portable Aesthetic Lasers 3Christopher and Dana Reeve Foundation Response to FDA Clearance of Geron's Clinical Trial 2
Rabbit polyclonal to Lck (phospho Y192) ( Abpromise for all tested applications). entrezGeneID: 3932 SwissProtID: P06239...
Goat polyclonal to Ephrin B2 ( Abpromise for all tested applications). entrezGeneID: 1948 SwissProtID: P52799...
Mouse monoclonal [RL13] to LAP1 ( Abpromise for all tested applications). SwissProtID: Q96NW7...
Sheep polyclonal to Malate Dehydrogenase ( Abpromise for all tested applications). Antigen: Full length protein - Pig heart malate dehydrogenase. Entrez Gene ID: 4190 Swiss Protein ID: P...
Biology Products: