Navigation Links
Just in time for spring: Scientists find the cellular on and off switch for allergies and asthma
Date:4/30/2009

If you're one of the millions who dread the spring allergy season, things are looking up. A research study appearing in the May 2009 issue of the Journal of Leukocyte Biology (http://www.jleukbio.org) shows how a team of American scientists have identified a previously unknown cellular switch that turns allergies and asthma both on and off. Equally important, this study also suggests that at least for some people with asthma and allergies, their problems might be caused by genes that prevent this switch from working properly. Taken together, this information is an important first step toward new medications that address the root causes of allergies, asthma and other similar diseases.

"This study uncovers some of the basic mechanisms that control whether or not people have asthma and allergies and the severity of the symptoms," said John Ryan, Ph.D., Professor of Biology at Virginia Commonwealth University, and a senior scientist involved in the research. "This understanding opens new avenues for treating these and other related diseases."

Ryan and colleagues made this discovery in mouse experiments that examined cells from bone marrow and umbilical cord blood that ultimately help create a type of immune cell (mast cells). Too many mast cells lead to an over-aggressive immune response, which causes allergies and asthma. The scientists found that when chemicals (cytokines IL-4 and IL-10) used to initiate an immune response (the "on switch") are added to developing mast cells, the developing cells die. Because bone marrow makes both mast cells and these cytokines, the researchers conclude that just as the cytokines serve as the "on switch" for the immune system, bone marrow cells also use them as the "off switch" to stop mast cells from getting out of hand. Further supporting their discovery was the finding that strains of mice prone to allergies and asthma had genes which affected the production of this chemical "off switch" in their bone marrow.

"The immune system has an incredible capacity for balance and counterbalance to maintain optimal and properly tuned immune responses," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, "The studies by Ryan and colleagues are an excellent example of this inherent self-regulation of the immune system and how an imbalance in mast cell regulation could contribute to allergy and disease."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Geoscientists meet to discuss Rocky Mountain geology
2. Gladstone scientists identify key factors in heart cell creation
3. Fire is important part of global climate change, report scientists
4. Scientists give a hand(edness) to the search for alien life
5. Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection
6. Marine scientists warn of potential for spring, summer red tide outbreak in Gulf of Maine
7. Singapore scientists synthesize gold to shed light on cells inner workings
8. UNC study: Scientists identify chemical compound that may stop deadly brain tumors
9. Caltech scientists control complex nucleation processes using DNA origami seeds
10. Scientists identify key gene that protects against leukemia
11. Scientists develop method for comprehensive proteome analysis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... 24, 2016 Ampronix facilitates superior patient care by providing unparalleled technology to ... display is the latest premium product recently added to the range of products distributed ... ... ... Imaging- LCD Medical Display- Ampronix News ...
(Date:5/3/2016)... 2016  Neurotechnology, a provider of high-precision biometric ... Biometric Identification System (ABIS) , a complete system ... ABIS can process multiple complex biometric transactions with ... fingerprint, face or iris biometrics. It leverages the ... MegaMatcher Accelerator , which have been used ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... be implemented as a compact web-based "all-in-one" system solution ... the biometric fingerprint reader or the door interface with ... of modern access control systems. The minimal dimensions of ... ID readers into the building installations offer considerable freedom ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ... advised by its major shareholders, Clean Technology Fund I, ... United States based venture capital funds which ... Biorem (on a fully diluted, as converted basis), that ... of their entire equity holdings in Biorem to TUS ...
(Date:6/27/2016)... Raleigh, NC (PRWEB) , ... June 27, 2016 ... ... a mission to bring innovative medical technologies, services and solutions to the healthcare ... development and implementation of various distribution, manufacturing, sales and marketing strategies that are ...
(Date:6/24/2016)... June 24, 2016  Regular discussions on a range of ... between the two entities said Poloz. Speaking at ... Ottawa , he pointed to the country,s inflation target, ... government. "In certain ... institutions have common economic goals, why not sit down and ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a ... eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research ... by providing practical tips, tools, and strategies for clinical researchers. , “The landscape ...
Breaking Biology Technology: