Navigation Links
'Jumping genes' find new homes in humans more often than previously thought
Date:6/24/2010

Transposons, or "jumping genes," make up roughly half of the human genome. Geneticists previously estimated that they replicate and insert themselves into new locations roughly one in every 20 live births.

New results, published in the June 25, 2010 issue of Cell, suggest that every newborn is likely to have a new transposon somewhere in his or her genome.

"Now it looks like every person might have a new insertion somewhere," says senior author Scott Devine, PhD, associate professor of medicine at the University of Maryland School of Medicine's Institute for Genome Sciences. "This is an under-appreciated mechanism for continuing mutation of the human genome."

The research was initiated at Emory University School of Medicine, where Devine was in the Department of Biochemistry. First author Rebecca Iskow, PhD (now a postdoctoral fellow at Brigham & Women's Hospital in Boston) was a graduate student at Emory. Two other papers on human transposons appear in the same issue of Cell.

Transposons resemble e-mail spam: short repeated sequences that have no obvious function other than making more of themselves. The full name for the type of transposon that is most abundant in the human genome is retrotransposon. The "retro" term comes from how they replicate: first, the DNA is transcribed (copied) into RNA, and the RNA is reverse-transcribed into DNA again. This process normally only happens during very early in development, when the cells that will become eggs and sperm have not turned down a separate path of differentiation.

"Transposons are the original selfish genes, and this strategy makes sense for them, because it makes sure new copies will get carried into the next generation," Devine says.

While working in Devine's lab as a graduate student, Iskow devised a technique for "amplifying" the stretches of individual genomes that border transposons and reading thousands of the junctions with advance
'/>"/>

Contact: Vince Dollard
vdollar@emory.edu
404-778-4580
Emory University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Jumping genes could make for safer gene delivery system
2. KGI professor contributes new insights on jumping genes
3. New data suggest jumping genes play a significant role in gene regulatory networks
4. The genetic secrets to jumping the species barrier
5. Jumping genes provide extensive raw material for evolution, Penn study finds
6. Gene regulation, not just genes, is what sets humans apart
7. Interaction of just 2 genes governs coloration patterns in mice
8. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
9. Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
10. Smoking turns on genes -- permanently
11. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)...   Medisafe ™, the leading global medication management ... and Android smartphones and tablets, announces ... platform to allow patients to track and correlate their ... patients will be able to visualize in real-time how ... such as glucose levels and blood pressure. ...
(Date:3/26/2015)... The Granite Club, ... club, today announced it has implemented a state-of-the-art access ... for members and staff, while restricting access to authorized ... selected FST,s IMID Access system because it has the ... and staff, in addition to unparalleled security," said ...
(Date:3/24/2015)... GARDENS, Fla. , March 24, 2015 /PRNewswire/ ... identity management solutions, today announced that its U.are.U ... clothing accessory retailer Goorin Bros . to ... Crossmatch biometrics-based solution secures access to the POS ... the increased risk of data breaches. ...
Breaking Biology News(10 mins):Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2
... problems, kidney disorders or high blood pressure could benefit ... new "smart" holograms, which can detect changes in, for ... and more reliable, write Chris Lowe and Cynthia Larbey ... recording of an optical interference pattern created when laser ...
... - Rainfall data from a NASA satellite show that summertime ... than on weekends. Scientists say air pollution from humans is ... and the day of the week is evident in data ... Midweek storms tend to be stronger, drop more rain and ...
... has demonstrated the role of a gene important to ... that requires coordination of differentiation of immature neural cells ... numbers. Until now, the mechanisms regulating these distinct cellular ... will be published in the Feb. 15 issue of ...
Cached Biology News:'Smart' holograms help patients help themselves 2NASA data link pollution to rainy summer days in the southeast 2NASA data link pollution to rainy summer days in the southeast 3Trainor Lab characterizes gene essential for prenatal development of nervous system 2
(Date:5/5/2015)... May 5, 2015 Roka Bioscience, Inc. (NASDAQ: ... testing solutions for the detection of foodborne pathogens,  today announced ... Bank of America Merrill Lynch 2015 Health Care Conference on ... at Encore at the Wynn, Las Vegas NV. ... presentation will be available through the investor relations section of ...
(Date:5/5/2015)... , May 5, 2015 Psyche Systems ... alliance which offers a first-of-its-kind platform that helps labs ... to lab results, transforms the way patients engage with ... Luminate Health provides a HIPAA-compliant digital platform ... access, manage, and understand their lab results, and uniquely ...
(Date:5/5/2015)... 2015 ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") (NYSE ... President and Chief Executive Officer, will present live ... DATE:  Thursday, May 7, 2015     TIME:  11:30 am ET/8:30 ... click the red "register/ watch presentations" button ... event where investors are invited to ask the ...
(Date:5/5/2015)... 2015 Research and Markets ( ... "Clinical Laboratory, Molecular Diagnostics and Genomic Testing ... - Europe Version" report to their offering. ... area of molecular diagnostics and pharmacogenics hold the ... market that is moving out of the national ...
Breaking Biology Technology:Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 3ImmunoCellular Therapeutics to Webcast Live at VirtualInvestorConferences.com on May 7 2European Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market 2015-2019 2
... Inc. ("Company") (OTCQB: SVFC.PK) announced today that the Company has ... of Thailand, http://www.StemCells21.com . Stem Cells 21 is ... the College of Anti-ageing Medicine and a member of ... Managing Director for the Stem Cells 21.  They have ...
... University of Southern California Marshall School of Business, ranked among ... Marshall School of Business Leadership Summit to be held ... at Los Angeles, newest landmark, the JW Marriot—just steps away ... A new dynamic format will keep interest high ...
... is Preeclampsia Awareness Month and to build awareness of ... period, thousands of families in 36 cities in the ... The Preeclampsia Foundation is holding the Promise ... help provide patient support and education, raise public awareness, ...
Cached Biology Technology:IntelliCell BioSciences Signs Technology Licensing Agreement with Stem Cells 21 Thailand 2USC Marshall School of Business 6th Annual Leadership Summit 2USC Marshall School of Business 6th Annual Leadership Summit 3Preeclampsia Awareness Month Marked By Promise Walks in 36 Cities 2Preeclampsia Awareness Month Marked By Promise Walks in 36 Cities 3
...
See product name for description....
... Staining Kit, 1. Select from homogeneous ... peptides on denaturing, native, and isoelectric ... with precast gels, buffer strips, and ... that of radioisotopes with ready-to-use silver ...
RAT ANTI MOUSE TCR V BETA 7:RPE Immunogen: T-cell lymphoma TK1...
Biology Products: