Navigation Links
'Jumping genes' find new homes in humans more often than previously thought

Transposons, or "jumping genes," make up roughly half of the human genome. Geneticists previously estimated that they replicate and insert themselves into new locations roughly one in every 20 live births.

New results, published in the June 25, 2010 issue of Cell, suggest that every newborn is likely to have a new transposon somewhere in his or her genome.

"Now it looks like every person might have a new insertion somewhere," says senior author Scott Devine, PhD, associate professor of medicine at the University of Maryland School of Medicine's Institute for Genome Sciences. "This is an under-appreciated mechanism for continuing mutation of the human genome."

The research was initiated at Emory University School of Medicine, where Devine was in the Department of Biochemistry. First author Rebecca Iskow, PhD (now a postdoctoral fellow at Brigham & Women's Hospital in Boston) was a graduate student at Emory. Two other papers on human transposons appear in the same issue of Cell.

Transposons resemble e-mail spam: short repeated sequences that have no obvious function other than making more of themselves. The full name for the type of transposon that is most abundant in the human genome is retrotransposon. The "retro" term comes from how they replicate: first, the DNA is transcribed (copied) into RNA, and the RNA is reverse-transcribed into DNA again. This process normally only happens during very early in development, when the cells that will become eggs and sperm have not turned down a separate path of differentiation.

"Transposons are the original selfish genes, and this strategy makes sense for them, because it makes sure new copies will get carried into the next generation," Devine says.

While working in Devine's lab as a graduate student, Iskow devised a technique for "amplifying" the stretches of individual genomes that border transposons and reading thousands of the junctions with advanced sequencing techniques, then comparing them to the reference human genome.

"The basic problem was that a new insertion can be anywhere within three billion base pairs how do you find it compared to all the other ones?" Devine says.

Ninety-seven percent of genomes the team surveyed had at least one rare insertion of the L1 variety of transposon that was present in only a single human in the study, and some genomes had several. Since the study surveyed 76 genomes, "rare" insertions could still be shared by large groups consisting of thousands of people. Rare insertions corresponded to the most recent transposons, which are less likely to have their jumping abilities impaired by other types of mutations.

Devine's team also showed that transposons frequently jump to new locations during the process of tumor formation. Surveying 20 lung tumors and comparing their genomes against the normal tissues they came from, the team found that six tumors had new transposon insertions that were not present in the normal adjacent tissues.

"This indicates that transposons are jumping in tumors and are generating a new kind of genomic instability," Devine says.

Transposons can inactivate tumor suppressor genes and can facilitate rearrangements that involve large stretches of chromosomes. Geneticists have already identified many transposons that interrupt genes and cause human diseases, including neurofibromatosis, hemophilia and breast cancer.

Scientists believe a process called methylation, which silences genes during differentiationalso shuts off transposons' ability to jump. Analyzing the patterns of mutations in the lung tumors suggested that during tumor formation, modified methylation patterns may be allowing transposons to re-awaken, Devine says.


Contact: Vince Dollard
Emory University

Related biology news :

1. Jumping genes could make for safer gene delivery system
2. KGI professor contributes new insights on jumping genes
3. New data suggest jumping genes play a significant role in gene regulatory networks
4. The genetic secrets to jumping the species barrier
5. Jumping genes provide extensive raw material for evolution, Penn study finds
6. Gene regulation, not just genes, is what sets humans apart
7. Interaction of just 2 genes governs coloration patterns in mice
8. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
9. Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
10. Smoking turns on genes -- permanently
11. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
Post Your Comments:
(Date:11/19/2015)... , Nov. 19, 2015  Although some 350 companies ... dominated by a few companies, according to Kalorama Information. These ... 51% of the market share of the 6.1 billion-dollar ... The World Market for Molecular Diagnostic s .    ... market is still controlled by one company and only ...
(Date:11/17/2015)... Paris , qui s,est tenu ... Paris , qui s,est tenu du 17 au ... l,innovation biométrique, a inventé le premier scanner couplé, qui ... même surface de balayage. Jusqu,ici, deux scanners étaient nécessaires, ... digitales. Désormais, un seul scanner est en mesure de ...
(Date:11/12/2015)...  A golden retriever that stayed healthy despite having ... provided a new lead for treating this muscle-wasting disorder, ... of MIT and Harvard and the University of São ... Cell, pinpoints a protective gene that boosts ... The Boston Children,s lab of Lou Kunkel , ...
Breaking Biology News(10 mins):
(Date:12/1/2015)... ... December 01, 2015 , ... The American ... Dr. J. Kyle Mathews will join fellow surgeons in the shared ... hysterectomy. , An experienced urogynecologist, founder of Plano Urogynecology Associates and Fellow ...
(Date:12/1/2015)... ) has ... Virology and Bacteriology Testing Market: Sales and ... Shares by Test, Innovative Technologies, Competitive Strategies, ... --> ) has announced the ... Bacteriology Testing Market: Sales and Volume Segment ...
(Date:11/30/2015)... ... November 30, 2015 , ... Global Stem Cells Group ... of a new closed system for isolating adipose-derived stem cells. The announcement starts a ... of adipose tissue. SVF is a component of the lipoaspirate obtained from liposuction of ...
(Date:11/30/2015)... ... ... Group announced the opening of a new core patient care hub with the opening ... facilities are part of GSCG’s expansion efforts in Latin America. , Both the Arica ... patients from around the world. , The clinics will be headed by Victor Perez, M.D. ...
Breaking Biology Technology: