July 2008 highlights(are elevated in women with PCOS during l...)

Date:6/19/2008

are elevated in women with PCOS during late gestation, provides an endocrine environment that leads to increased gonadotropin release both prenatally and postnatally, as well as leading to increased androgen levels in female infants. While these changes occurred in the absence of elevations of estrogen levels in the fetusessuggesting androgen-mediated prenatal programming may be one of the factors that can contribute to the constellation of symptoms that define PCOSlocal tissue conversion of androgen to estrogen may provide additional programming.

David H. Abbott, Deborah K. Barnett, Jon E. Levine, Vasantha Padmanabhan, Daniel A. Dumesic, Steve Jacoris, and Alice F. Tarantal.
Endocrine Antecedents of Polycystic Ovary Syndrome in Fetal and Infant Prenatally Androgenized Female Rhesus Monkeys.
Biol Reprod 2008; 79: 154-163. Published online in BOR-Papers in Press on 2 April 2008; DOI 10.1095/biolreprod.108.067702 http://www.biolreprod.org/cgi/content/abstract/79/1/154?etoc

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Contact: Judith Jansen ssr@ssr.org 608-256-2777 Society for the Study of Reproduction Source:Eurekalert

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