Navigation Links
July 2008 highlights
Date:6/19/2008

Now we knowfor sure.

Adding to a growing literature on the role of metabolic enzymes and ATP production in sperm function, it is now shown that one lactate dehydrogenase family member, LDHC, is required for male fertility. Several decades of work on this glycolytic enzyme had shown that it is expressed primarily in testis, but its functional significance had been only speculative. In an article on p. 26 Odet et al. report that male mice homozygous for a targeted disruption of Ldhc are severely impaired in fertility, whereas females are fertile. The fertility defects include impaired sperm motility, reduction of capacitation-related protein phosphorylation, and fertilization defectsall probably due to compromised ATP production. Thus, LDHC is required for glycolysis and ATP production in the sperm tail, and this finding may lead to new insights into infertility in men.

Fanny Odet, Chongwen Duan, William D. Willis, Eugenia H. Goulding, Aisha Kung, Edward M. Eddy, and Erwin Goldberg.
Expression of the Gene for Mouse Lactate Dehydrogenase C (Ldhc) Is Required for Male Fertility.
Biol Reprod 2008; 79:36-34. Published online in BOR-Papers in Press on 26 March 2008; DOI 10.1095/biolreprod.108.068353 http://www.biolreprod.org/cgi/content/abstract/79/1/36?etoc


Prenatal programming.

Polycystic ovary syndrome, or PCOS, is among the most common causes of infertility, conservatively affecting 6-8% of women. Increasing evidence suggests symptoms of PCOS arise during the pubertal process; however, the cause or causes of PCOS remain unclear. Although genetic predispositions likely exist, environmental causes have also been suggested. In an article on p. 154 of this issue, Abbott and coworkers provide evidence in a primate model that prenatal exposure to androgens, which are elevated in women with PCOS during late gestation, provides an endocrine environment that leads to increased gonadotropin release both prenatally and postnatally, as well as leading to increased androgen levels in female infants. While these changes occurred in the absence of elevations of estrogen levels in the fetusessuggesting androgen-mediated prenatal programming may be one of the factors that can contribute to the constellation of symptoms that define PCOSlocal tissue conversion of androgen to estrogen may provide additional programming.

David H. Abbott, Deborah K. Barnett, Jon E. Levine, Vasantha Padmanabhan, Daniel A. Dumesic, Steve Jacoris, and Alice F. Tarantal.
Endocrine Antecedents of Polycystic Ovary Syndrome in Fetal and Infant Prenatally Androgenized Female Rhesus Monkeys.
Biol Reprod 2008; 79: 154-163. Published online in BOR-Papers in Press on 2 April 2008; DOI 10.1095/biolreprod.108.067702 http://www.biolreprod.org/cgi/content/abstract/79/1/154?etoc


'/>"/>

Contact: Judith Jansen
ssr@ssr.org
608-256-2777
Society for the Study of Reproduction
Source:Eurekalert

Related biology news :

1. Highlights from the June 2008 Journal of the American Dietetic Association
2. New text highlights role of microorganisms in alternative energy development
3. June GEOSPHERE media highlights
4. Highlights from the May 2008 Journal of the American Dietetic Association
5. Biology of Reproduction highlights
6. Symposium on energy research highlights future challenges, opportunities
7. AGU Journal Highlights -- March 19, 2008
8. Media highlights for February in Biophysical Journal
9. March GEOLOGY and GSA TODAY media highlights
10. AGU journal highlights -- Feb. 26, 2008
11. Media highlights in the March 1 issue of Biophysical Journal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2016)... 20, 2016  As part of its longstanding mission to ... genetics company, recently released its latest children,s book, titled ... focuses on the topics of inheritance and variation of traits ... taught in elementary school classrooms in the US. ... illustrator Ariana Killoran , whose previous book with 23andMe, ...
(Date:12/16/2016)... --  IdentyTechSolutions America LLC , a leading provider ... a cutting-edge manufacturer of software and hardware security ... integrated solutions that comprise IDT biometric readers and ... IdentyTech,s customers with combined physical identification and anti-tailgating ... theft. "We are proud to use ...
(Date:12/15/2016)... 2016 ... Research and Markets has announced the addition of the ... The report forecasts the global military biometrics market to grow at ... report has been prepared based on an in-depth market analysis with inputs ... prospects over the coming years. The report also includes a discussion of ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... ... 18, 2017 , ... uBiome, the leading microbial genomics company, ... Editor, Dr. Elisabeth Bik, in the December 2016 issue of the Dutch Journal ... October 2016 from her previous position at Stanford University School of Medicine and ...
(Date:1/18/2017)...  HUYA Bioscience International, (HUYA), the leader in accelerating ... pharmaceutical innovations, announced today a strategic collaboration agreement with ... (referred to as CAS Innovation). The collaboration will focus ... scientists at CAS to meet the medical needs of ... first company to have recognized China,s ...
(Date:1/18/2017)... 18, 2017  Market Research Future published a half-cooked research report ... to grow at a CAGR of 12% during the period 2016 ... ... the abnormal cell division without any control. These abnormal cells have ... These cancer cells can spread to other parts of the body ...
(Date:1/17/2017)... Jan. 17, 2017 The Global Implantable ... CAGR of around 7.5% over the next decade ... of the prominent trends that the market is ... diseases & graft transplant surgeries and medical implants ... market is categorized into immunomodulatory biomaterials, natural, polymers, ...
Breaking Biology Technology: