Navigation Links
July 2008 highlights
Date:6/19/2008

Now we knowfor sure.

Adding to a growing literature on the role of metabolic enzymes and ATP production in sperm function, it is now shown that one lactate dehydrogenase family member, LDHC, is required for male fertility. Several decades of work on this glycolytic enzyme had shown that it is expressed primarily in testis, but its functional significance had been only speculative. In an article on p. 26 Odet et al. report that male mice homozygous for a targeted disruption of Ldhc are severely impaired in fertility, whereas females are fertile. The fertility defects include impaired sperm motility, reduction of capacitation-related protein phosphorylation, and fertilization defectsall probably due to compromised ATP production. Thus, LDHC is required for glycolysis and ATP production in the sperm tail, and this finding may lead to new insights into infertility in men.

Fanny Odet, Chongwen Duan, William D. Willis, Eugenia H. Goulding, Aisha Kung, Edward M. Eddy, and Erwin Goldberg.
Expression of the Gene for Mouse Lactate Dehydrogenase C (Ldhc) Is Required for Male Fertility.
Biol Reprod 2008; 79:36-34. Published online in BOR-Papers in Press on 26 March 2008; DOI 10.1095/biolreprod.108.068353 http://www.biolreprod.org/cgi/content/abstract/79/1/36?etoc


Prenatal programming.

Polycystic ovary syndrome, or PCOS, is among the most common causes of infertility, conservatively affecting 6-8% of women. Increasing evidence suggests symptoms of PCOS arise during the pubertal process; however, the cause or causes of PCOS remain unclear. Although genetic predispositions likely exist, environmental causes have also been suggested. In an article on p. 154 of this issue, Abbott and coworkers provide evidence in a primate model that prenatal exposure to androgens, which are elevated in women with PCOS during late gestation, provides an endocrine environment that leads to increased gonadotropin release both prenatally and postnatally, as well as leading to increased androgen levels in female infants. While these changes occurred in the absence of elevations of estrogen levels in the fetusessuggesting androgen-mediated prenatal programming may be one of the factors that can contribute to the constellation of symptoms that define PCOSlocal tissue conversion of androgen to estrogen may provide additional programming.

David H. Abbott, Deborah K. Barnett, Jon E. Levine, Vasantha Padmanabhan, Daniel A. Dumesic, Steve Jacoris, and Alice F. Tarantal.
Endocrine Antecedents of Polycystic Ovary Syndrome in Fetal and Infant Prenatally Androgenized Female Rhesus Monkeys.
Biol Reprod 2008; 79: 154-163. Published online in BOR-Papers in Press on 2 April 2008; DOI 10.1095/biolreprod.108.067702 http://www.biolreprod.org/cgi/content/abstract/79/1/154?etoc


'/>"/>

Contact: Judith Jansen
ssr@ssr.org
608-256-2777
Society for the Study of Reproduction
Source:Eurekalert

Related biology news :

1. Highlights from the June 2008 Journal of the American Dietetic Association
2. New text highlights role of microorganisms in alternative energy development
3. June GEOSPHERE media highlights
4. Highlights from the May 2008 Journal of the American Dietetic Association
5. Biology of Reproduction highlights
6. Symposium on energy research highlights future challenges, opportunities
7. AGU Journal Highlights -- March 19, 2008
8. Media highlights for February in Biophysical Journal
9. March GEOLOGY and GSA TODAY media highlights
10. AGU journal highlights -- Feb. 26, 2008
11. Media highlights in the March 1 issue of Biophysical Journal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a provider ... MegaMatcher Automated Biometric Identification System (ABIS) , ... multi-biometric projects. MegaMatcher ABIS can process multiple complex ... any combination of fingerprint, face or iris biometrics. ... SDK and MegaMatcher Accelerator , which ...
(Date:4/26/2016)... India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a product ... and Onegini today announced a partnership to integrate ... solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... to provide their customers enhanced security to access ...
(Date:4/15/2016)...  A new partnership announced today will help ... in a fraction of the time it takes ... life insurance policies to consumers without requiring inconvenient ... Diagnostics, rapid testing (A1C, Cotinine and HIV) and ... weight, pulse, BMI, and activity data) available at ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ... advised by its major shareholders, Clean Technology Fund I, ... United States based venture capital funds which ... Biorem (on a fully diluted, as converted basis), that ... of their entire equity holdings in Biorem to TUS ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... will join the faculty of the University of North Carolina Kenan-Flagler Business ... strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers ... 5000 and the 6000i models are higher end machines that use the more unconventional ... spectrophotometer’s light beam from the bottom of the cuvette holder. , FireflySci has ...
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
Breaking Biology Technology: