Navigation Links
July 2008 highlights
Date:6/19/2008

Now we knowfor sure.

Adding to a growing literature on the role of metabolic enzymes and ATP production in sperm function, it is now shown that one lactate dehydrogenase family member, LDHC, is required for male fertility. Several decades of work on this glycolytic enzyme had shown that it is expressed primarily in testis, but its functional significance had been only speculative. In an article on p. 26 Odet et al. report that male mice homozygous for a targeted disruption of Ldhc are severely impaired in fertility, whereas females are fertile. The fertility defects include impaired sperm motility, reduction of capacitation-related protein phosphorylation, and fertilization defectsall probably due to compromised ATP production. Thus, LDHC is required for glycolysis and ATP production in the sperm tail, and this finding may lead to new insights into infertility in men.

Fanny Odet, Chongwen Duan, William D. Willis, Eugenia H. Goulding, Aisha Kung, Edward M. Eddy, and Erwin Goldberg.
Expression of the Gene for Mouse Lactate Dehydrogenase C (Ldhc) Is Required for Male Fertility.
Biol Reprod 2008; 79:36-34. Published online in BOR-Papers in Press on 26 March 2008; DOI 10.1095/biolreprod.108.068353 http://www.biolreprod.org/cgi/content/abstract/79/1/36?etoc


Prenatal programming.

Polycystic ovary syndrome, or PCOS, is among the most common causes of infertility, conservatively affecting 6-8% of women. Increasing evidence suggests symptoms of PCOS arise during the pubertal process; however, the cause or causes of PCOS remain unclear. Although genetic predispositions likely exist, environmental causes have also been suggested. In an article on p. 154 of this issue, Abbott and coworkers provide evidence in a primate model that prenatal exposure to androgens, which are elevated in women with PCOS during late gestation, provides an endocrine environment that leads to increased gonadotropin release both prenatally and postnatally, as well as leading to increased androgen levels in female infants. While these changes occurred in the absence of elevations of estrogen levels in the fetusessuggesting androgen-mediated prenatal programming may be one of the factors that can contribute to the constellation of symptoms that define PCOSlocal tissue conversion of androgen to estrogen may provide additional programming.

David H. Abbott, Deborah K. Barnett, Jon E. Levine, Vasantha Padmanabhan, Daniel A. Dumesic, Steve Jacoris, and Alice F. Tarantal.
Endocrine Antecedents of Polycystic Ovary Syndrome in Fetal and Infant Prenatally Androgenized Female Rhesus Monkeys.
Biol Reprod 2008; 79: 154-163. Published online in BOR-Papers in Press on 2 April 2008; DOI 10.1095/biolreprod.108.067702 http://www.biolreprod.org/cgi/content/abstract/79/1/154?etoc


'/>"/>

Contact: Judith Jansen
ssr@ssr.org
608-256-2777
Society for the Study of Reproduction
Source:Eurekalert

Related biology news :

1. Highlights from the June 2008 Journal of the American Dietetic Association
2. New text highlights role of microorganisms in alternative energy development
3. June GEOSPHERE media highlights
4. Highlights from the May 2008 Journal of the American Dietetic Association
5. Biology of Reproduction highlights
6. Symposium on energy research highlights future challenges, opportunities
7. AGU Journal Highlights -- March 19, 2008
8. Media highlights for February in Biophysical Journal
9. March GEOLOGY and GSA TODAY media highlights
10. AGU journal highlights -- Feb. 26, 2008
11. Media highlights in the March 1 issue of Biophysical Journal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2016)... LONDON , June 3, 2016 /PRNewswire/ ... Transport Management) von Nepal ... ,Angebot und Lieferung hochsicherer geprägter Kennzeichen, einschließlich ... weltweit führend in der Produktion und Implementierung ... an der Ausschreibung im Januar teilgenommen, aber ...
(Date:6/1/2016)... , June 1, 2016 Favorable ... Election Administration and Criminal Identification to Boost Global Biometrics ... recently released TechSci Research report, " Global Biometrics Market ... Competition Forecast and Opportunities, 2011 - 2021", the global ... by 2021, on account of growing security concerns across ...
(Date:5/12/2016)... 2016 WearablesResearch.com , a brand of ... results from the Q1 wave of its quarterly wearables ... consumers, receptivity to a program where they would receive ... insurance company. "We were surprised to see ... Michael LaColla , CEO of Troubadour Research, "primarily because ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... -- The Prostate Cancer Foundation (PCF) is pleased to announce 24 new ... prostate cancer. Members of the Class of 2016 were selected from a pool ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software company, ... Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , “I ... President and COO of STACS DNA. “In further expanding our capacity as a scientific ...
(Date:6/23/2016)... -- Andrew D Zelenetz , ... Published recently in Oncology & ... Andrew D Zelenetz , discusses the fact ... placing an increasing burden on healthcare systems worldwide, ... the patents on many biologics expiring, interest in ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... a new line of intelligent tools designed, tuned and optimized exclusively for Okuma ... 12–17 in Chicago. The result of a collaboration among several companies with expertise ...
Breaking Biology Technology: