Navigation Links
Joslin study finds clue to birth defects in babies of mothers with diabetes
Date:10/16/2011

BOSTON -- October 17, 2011-- In a paper published today in Diabetologia, a team at Joslin Diabetes Center, headed by Mary R. Loeken, PhD, has identified the enzyme AMP kinase (AMPK) as key to the molecular mechanism that significantly increases the risk of neural tube defects such as spina bifida and some heart defects among babies born to women with diabetes.

Even if women with diabetes -- either type 1 or type 2 -- work vigilantly to control their blood sugar levels around the time of conception, the risk of a defect is still twice that of the general population. This finding could lead to strategies to interfere with the mechanism and reduce the chances of such birth defects occurring.

Previous studies published by Loeken's lab showed that maternal hyperglycemia (high blood sugar) causes oxidative stress in the embryo, and inhibits expression of the Pax3 gene. Pax3 is essential to the formation of the neural tube, which in the embryo is the precursor to the brain and spinal cord. Oxidative stress results when oxidized molecules - called free radicals - are created faster than they can be eliminated.

However, Loeken said, it was not known how the cells that express Pax3 could sense the oxidative stress and why oxidative stress, which occurs throughout the embryo, only damages selective structures such as the neural tube.

In the paper published today, Loeken's team identifies the key to the process as AMP kinase, which is activated by oxidative stress and was found to signal the cell nucleus to block the expression of Pax3.

"The stimulation of a metabolism-sensing enzyme that can regulate specific genes explains how oxidative stress, which is generated throughout the embryo during maternal hyperglycemia, causes malformation of specific embryo structures," Loeken said.

"We now know that we must do whatever we can to prevent AMPK from being stimulated," said Loeken, who is a research invest
'/>"/>

Contact: Jeffrey Bright
jeffrey.bright@joslin.harvard.edu
Joslin Diabetes Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Joslin researchers identify pathways leading to activation of good fat
2. Joslin researchers identify new target for treatment of type 2 diabetes and prediabetes
3. Joslin research finds nearly three-quarters of youths with diabetes insufficient in vitamin D
4. First genome-wide association study for dengue identifies candidate susceptibility genes
5. Largest ever genetic study of liver function could point the way to new treatments
6. Study reveals new role for RNA interference during chromosomal replication
7. Method of studying roots rarely used in wetlands improves ecosystem research
8. Southampton scientists herald significant breakthrough in study of chlamydia
9. Einstein College of Medicine given $6.7 million to study congenital heart defect genetics
10. National Science Foundation selects University of Colorado Denver team to study city sustainability
11. Worms among first animals to surface after K-T extinction event, CU-led study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Joslin study finds clue to birth defects in babies of mothers with diabetes
(Date:4/18/2014)... used techniques like X-ray crystallography and nuclear magnetic resonance ... structure of molecules, but such efforts have long been ... of a specific molecule and often in ordered and ... but impossible to peer into the structure of most ... soon be a thing of the past. , ...
(Date:4/18/2014)... researchers have published soil organic carbon sequestration rates. ... organic carbon can be sequestered by simply switching from ... there is a growing body of research with evidence ... cover crops, small grains, and forages may not be ... , "Some studies have shown that both moldboard and ...
(Date:4/18/2014)... as they,re planted may be good news for a garden. ... wild, a plant whose seeds sprouted at the first ,warm ... an insurance policy against late frosts or unexpected dry spells, ... Plants whose seeds put off sprouting until conditions are ... team of researchers working at the National Evolutionary Synthesis Center ...
Breaking Biology News(10 mins):MRI, on a molecular scale 2MRI, on a molecular scale 3Researchers question published no-till soil organic carbon sequestration rates 2Researchers question published no-till soil organic carbon sequestration rates 3Researchers question published no-till soil organic carbon sequestration rates 4Plants with dormant seeds give rise to more species 2
... for Cancer Research recognizes the first anniversary of the ... signed into law by President Obama on June 22, ... Drug Administration (FDA) to regulate the marketing, advertising and ... today include restrictions on youth access to tobacco products, ...
... why a baby,s brain is particularly flexible and why ... learn a lot? A group of researchers from the ... Dynamics and Self-Organization in Gttingen, the Schiller University in ... a new explanation: Maybe it is because the brain ...
... of our ancestors and ape cousins may suggest that humans are ... new study has found the opposite is true, with major implications ... findings suggest that early modern humans did not necessarily need to ... nuts - and perhaps less tough foods such as meat - ...
Cached Biology News:AACR recognizes 1-year anniversary of tobacco law 2Growing brain is particularly flexible 2Humans have a mighty bite 2
(Date:1/15/2014)... The Pittcon Organizing Committee is pleased to announce that Innovative ... e-Journal and producer of Food Labs Conference , ... the co-location of Food Labs Conference to be held in ... fee to attend the two-day Food Lab Conference, March 4-5. ...
(Date:1/15/2014)... ­ RedBrick Health , a fast-growing leader in ... that EmblemHealth , the New York ... providing the RedBrick Compass health assessment, combined with the ... its members. EmblemHealth is among the first health plans ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how ... latent viruses is the Epstein Barr Virus (EBV), and one ... is a chronic inflammatory disease that destroys the body’s joints. ... patients have high concentrations of EBV DNA in their bodies ...
(Date:1/15/2014)... Jan. 15, 2014 TaiGen Biotechnology Company, Limited ("TaiGen") ... with R-Pharm, a leading Russian pharmaceutical company, to develop ... Russian Federation , Turkey ... (CIS). Nemonoxacin is a novel antibiotic for the treatment of ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... equipment market is poised to exceed $539 million by 2012. Consumables, ... lucrative areas that are expected to drive the industry,s growth in ... ... November 10, 2008 -- Economic trends, mergers & acquisitions in the ...
... new type of small-scale electric power generator able to ... of zinc oxide wires encapsulated in a flexible plastic ... new "flexible charge pump" generator is the fourth generation ... the piezoelectric properties of zinc oxide structures to harvest ...
... Mo., Nov. 7 In refusing to a ... removal and replacement of its,current directors, management of ... developer and manufacturer of diagnostic products whose,American Depository ... that the preservation of their jobs and positions ...
Cached Biology Technology:Calorimeters and Thermal Analysis Equipment Market to Exceed $539 Million by 2012, According to New Report by Global Industry Analysts 2Calorimeters and Thermal Analysis Equipment Market to Exceed $539 Million by 2012, According to New Report by Global Industry Analysts 3New small-scale generator produces alternating current by stretching zinc oxide wires 2New small-scale generator produces alternating current by stretching zinc oxide wires 3Trinity Biotech Management Refuses to Honor Call for a Special Meeting of Shareholders 2Trinity Biotech Management Refuses to Honor Call for a Special Meeting of Shareholders 3
... BioChains human adult normal Mega Western ... proprietary technology. The Mega Western Protein Arrays ... lysates from documented tissue sources. A protein ... well electrophoresesed along with a Protein molecular ...
... applications not requiring confocal, the BD Pathway ... the Pathway 435. And, the Pathway 415 ... applications require it. High-performance, ... to use the laser autofocus, camera autofocus, ...
fully automated system for the processing of microarrays on microscope slides...
... containing Dermal Fibroblasts (rabbit) and media. Cryo-preserved ... 10% DMSO at passage 25 (approx), supplied ... cell culture is supplied as a long-term ... additional 6 months of continuous growth from ...
Biology Products: