Navigation Links
Joslin researchers identify pathways leading to activation of good fat
Date:9/20/2011

BOSTON September 20, 2011 Researchers at the Joslin Diabetes Center have identified for the first time two molecular pathways that are critical to activating a type of "good" fat found in the body, a discovery that could play an important role in the fight against obesity and diabetes.

The fat, called brown fat, actually burns energy rather than storing it, which the more common white fat does.

The study, published in the October issue of Endocrinology, sought to learn more about how to get brown fat cells to grow. It identified two molecular pathways that lead to a protein called necdin that blocks brown fat growth.

With this information, researchers can look for ways to modify the steps along the pathways, either to stimulate another protein, called CREB, which shuts down necdin, or block a different protein called FoxO1, located along the second pathway, which stimulates necdin. The study showed for the first time that the two proteins can bind directly to the necdin gene.

"This is a very important piece of the puzzle," said Aaron Cypess, MD, PhD an assistant investigator and staff physician at Joslin and lead author of the paper. "It provides new opportunities. The point is that we have got to learn how to grow these brown fat cells. There's a lot of missing information. We filled in some of the important missing pieces."

Based on previous research, including a 2005 paper by Yu-Hua Tseng, Ph.D., a Joslin investigator who also is senior author of today's paper, there was some evidence that the two pathways were important to the process of brown fat growth.

In today's study, the researchers conducted tests in vitro on different cell lines derived from brown fat taken from mice. "We used different drugs to stimulate or block the signaling pathways that we thought were important," Dr. Cypess said. "The result was that we defined the two pathways. We found what goes to what to cause something t
'/>"/>

Contact: Jeffrey Bright
jeffrey.bright@joslin.harvard.edu
617-309-1957
Joslin Diabetes Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Joslin researchers identify new target for treatment of type 2 diabetes and prediabetes
2. Joslin research finds nearly three-quarters of youths with diabetes insufficient in vitamin D
3. Kansas researchers find enriched infant formulas benefit brain and heart
4. Researchers sequence dark matter of life
5. Researchers discover a switch that controls stem cell pluripotency
6. MU researchers unveil new method for detecting lung cancer in Nature article
7. Notre Dame researchers demonstrate antibiotic sensing event central to MSRA antibiotic resistance
8. Researchers uncover a potential new benefit of pure maple syrup on liver health
9. EPA grants help Wayne State researchers stave off Great Lakes environmental invaders
10. UTHealth, BCM researchers find common gene variant associated with aortic dissection
11. Researchers find high levels of toxic PCBs in Indiana Harbor and Ship Canal
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Joslin researchers identify pathways leading to activation of good fat
(Date:8/18/2015)... 2015  Navitas today announced that it ... Submission Content Management webinar scheduled on August ... to the Implementation of Regulatory Submission Standards ... industry, vendors, health authorities, consultants and the ... a standard method of implementing electronic submission ...
(Date:8/17/2015)... Aug. 17, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market and creator ... campaign for Q4 2015. The new marketing campaign is ... of Amplitude Marketing Group ( http://amplitudemarketing.com/ ) and TPMG ... a leader in retail driven marketing and brand awareness ...
(Date:8/12/2015)... , August 12, 2015 ... of mobile payment innovation and advanced biometrics technology is ... the way consumers rely on using their credit cards, ... reinventing the future for payment services led by companies ... NXTD ), :  Google, Inc. (NASDAQ: GOOG ), ...
Breaking Biology News(10 mins):Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6
... WASHINGTON, Oct. 30 -- Two groups of researchers, one ... announcing the development of new optical techniques for visualizing ... The published results are the first to showcase the ... allows authors to submit a manuscript that includes large ...
... has been heralded for its ability to reduce the risk ... some people, vitamin E causes bleeding. Scientists have known for ... by interfering with vitamin K, which is essential in blood ... two vitamins interact. Nutrition researcher Maret Traber of Oregon State ...
... CA and New York, NY, October 30, 2008 ... autoimmune diseases, and the Juvenile Diabetes Research Foundation, the ... today announced a partnership to support Bayhill,s ongoing Phase ... to reverse the immune response that causes type 1 ...
Cached Biology News:OSA's ISP launches with research on breathing disorders and congenital heart defects 2OSA's ISP launches with research on breathing disorders and congenital heart defects 3OSA's ISP launches with research on breathing disorders and congenital heart defects 4Bayhill Therapeutics and the Juvenile Diabetes Research Foundation announce research collaboration 2Bayhill Therapeutics and the Juvenile Diabetes Research Foundation announce research collaboration 3
(Date:9/1/2015)... September 2, 2015 ... die Forschung und Entwicklung neuartiger Therapien für ... Darmerkrankungen und Reizdarm konzentriert, erhält vom US ... sein neues Medikament patentiert wird. Das Medikament ... bei Kindern verhindert und Entzündungen vorbeugt.   ...
(Date:9/1/2015)... 2015 Prostate cancer is the second ... men. One in seven men will be diagnosed ... are diagnosed annually. That said, not every diagnosis ... new technique, MRI Fusion Biopsy, to more accurately ... only the affected areas and monitoring areas ...
(Date:9/1/2015)... ... September 01, 2015 , ... VetStem Biopharma announces new ... facet joint problems can be caused by injuries and abnormalities of the cervical ... roots or of the spinal cord itself. This can manifest itself as any ...
(Date:9/1/2015)... , Sept. 1, 2015   Medfusion, ... facilitating the relationship between doctors and patients, today ... Durham, N.C. -based venture capital firms. ... and business association with Bull City Venture Partners ... , Medfusion Founder and Executive Chairman. "Both firms, ...
Breaking Biology Technology:Das Patent von Swecure zur Verhinderung von Allergien bei Kindern wird in den USA zugelassen 2September Is Prostate Cancer Awareness Month 2September Is Prostate Cancer Awareness Month 3September Is Prostate Cancer Awareness Month 4VetStem Biopharma Announces New Clinical Research Program for Equine Cervical Facet Joint Disease 2VetStem Biopharma Announces New Clinical Research Program for Equine Cervical Facet Joint Disease 3Medfusion Secures Funding to Continue Evolution and Advance Mobile Strategy 2Medfusion Secures Funding to Continue Evolution and Advance Mobile Strategy 3
... decreased by 33% in 2008; Forecast cutting net operating expenses ... NDA submission in Q2 2009 SEATTLE, March 16 Cell ... accomplishments and financial results for the fourth quarter and year ... , ...
... begins to fall, take two bricks and place them side ... In the morning, the bricks will be covered with snow ... space between and around the bricks. , What you will ... occurs at the smallest of scales on an integrated optical ...
... a specialized protein-based therapeutics oncology company, is proud to announce ... Biopharma, a subsidiary of Validapro BioSciences Inc. to encompass the ... under development at Med Discovery. , ... ...
Cached Biology Technology:Cell Therapeutics, Inc. (CTI) Reports 2008 Fourth Quarter and Year End Financial Results 2Cell Therapeutics, Inc. (CTI) Reports 2008 Fourth Quarter and Year End Financial Results 3Cell Therapeutics, Inc. (CTI) Reports 2008 Fourth Quarter and Year End Financial Results 4Cell Therapeutics, Inc. (CTI) Reports 2008 Fourth Quarter and Year End Financial Results 5Cell Therapeutics, Inc. (CTI) Reports 2008 Fourth Quarter and Year End Financial Results 6Cell Therapeutics, Inc. (CTI) Reports 2008 Fourth Quarter and Year End Financial Results 7Cell Therapeutics, Inc. (CTI) Reports 2008 Fourth Quarter and Year End Financial Results 8New organic material may speed Internet access 2New organic material may speed Internet access 3New organic material may speed Internet access 4New organic material may speed Internet access 5Med Discovery and Laborium Biopharma Extend Their Development Partnership to Include Mammalian Cell Culture Processes and Clinical Manufacturing for All Products in Med Discovery's Portfolio 2
... and ES1301 mutS are mismatch repair minus ... strains prevents repair of the newly synthesized ... efficiencies and making them helpful in such ... II Mutagenesis Systems. Both ES1301 and BMH ...
propidium iodide *1.0 mg/mL solution in water*...
Applications: (+) Immunocytochemistry and immunohistochemistry...
MOUSE ANTI RAT KAPPA/LAMBDA:HRP Immunogen: MARK-1: Rat kappa light chains (IR202 and IR968)MARL-15: Rat lambda light chains (RH58, IR31)...
Biology Products: