Navigation Links
Joint research into an enzyme that causes genetic diseases
Date:8/5/2009

This release is available in Spanish.

Researchers from CIC bioGUNE's Structural Biology Unit and Columbia University (New York) have conducted a joint research project, published in the prestigious scientific journal Structure, to gain in-depth knowledge of the structure of pyruvate carboxylase when it is in solution (in the "natural" state).

Pyruvate carboxylase is a metabolic enzyme that plays a fundamental role in the metabolism of fatty acids (the components of fats) and sugars. When its function is not adequately performed (for example, when mutations in the gene arise) diverse metabolic diseases of genetic origin are triggered, amongst them lactic acidaemia, hypoglycaemia, and psycho-motor retardation. At the same time, being at a metabolic crossroads, pyruvate carboxylase is potentially a target in obesity and diabetes treatments.

The paper presents the enzyme's structure under physiological conditions for the first time, and reveals which of the previous models is the correct one.

Mikel Valle, a researcher from CIC bioGUNE's Structural Biology Unit explains that This is the start of a highly ambitious study which is being carried out at CIC bioGUNE and which aims to discover the functioning of pyruvate carboxylase. This they shall achieve by observing its structure throughout its functional cycle, in the hope of discovering its structure in each of the steps it follows during its functioning.


'/>"/>

Contact: Oihane Lakar
oihane@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Page: 1

Related biology news :

1. Joint statement by German science organizations on green genetic engineering
2. Imperial College London and NTU collaborate to offer joint Ph.D. programs in engineering and science
3. Exercise no danger for joints
4. DOE Joint Genome Institute completes soybean genome
5. Low-gravity training machine reduces joint, muscle impacts, says CU-Boulder study
6. US Department of Energy Joint Genome Institute announces new genome sequencing projects
7. Researchers coat titanium with polymer to improve integration of joint replacements
8. Argonne-University of Chicago joint venture bolsters genomic sequencing capabilities
9. NASA presentations at American Geophysical Union Joint Assembly
10. Mechanisms of plant-fungi symbiosis characterized by DOE Joint Genome Institute
11. Electronic switch opens doors in rheumatoid joints
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... Forecasts by Product Type (EAC), Biometrics, Card-Based ... & Logistics, Government & Public Sector, Utilities / Energy ... Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality & ... for a definitive report on the $27.9bn Access Control ... ...
(Date:4/5/2017)... April 4, 2017 KEY FINDINGS ... expand at a CAGR of 25.76% during the forecast ... the primary factor for the growth of the stem ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem cell ... application, and geography. The stem cell market of the ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, ... Hack the Genome hackathon at Microsoft,s headquarters ... two-day competition will focus on developing health and wellness ... Hack the Genome is the first ... tremendous. The world,s largest companies in the genomics, tech ...
Breaking Biology News(10 mins):
(Date:7/25/2017)... (PRWEB) , ... July 25, 2017 , ... ... that enhance the microbiome and improve efficiency of livestock farming while reducing the ... it has licensed additional intellectual property from Cornell University. , These new ...
(Date:7/24/2017)... , July 24, 2017 Intralytix, Inc. announced ... from Lesaffre, a French family group. This investment marks ... to develop and commercialize bacteriophage-based products, for various benefits ... interest. As ... designs manufactures and markets innovative solutions for baking, food ...
(Date:7/24/2017)... , ... July 24, 2017 ... ... Kenny Soulstring, today announced that the stock market news outlet had initiated ... assessment diagnostic testing that screens and identifies exposure, progression and risk analysis ...
(Date:7/20/2017)... ... July 20, 2017 , ... ... leading radiology and imaging centers around the U.S. that offer MR Elastography for ... alternative to needle biopsy for staging liver fibrosis assessment. , “MRE:connect was ...
Breaking Biology Technology: