Navigation Links
Joint research into an enzyme that causes genetic diseases
Date:8/5/2009

This release is available in Spanish.

Researchers from CIC bioGUNE's Structural Biology Unit and Columbia University (New York) have conducted a joint research project, published in the prestigious scientific journal Structure, to gain in-depth knowledge of the structure of pyruvate carboxylase when it is in solution (in the "natural" state).

Pyruvate carboxylase is a metabolic enzyme that plays a fundamental role in the metabolism of fatty acids (the components of fats) and sugars. When its function is not adequately performed (for example, when mutations in the gene arise) diverse metabolic diseases of genetic origin are triggered, amongst them lactic acidaemia, hypoglycaemia, and psycho-motor retardation. At the same time, being at a metabolic crossroads, pyruvate carboxylase is potentially a target in obesity and diabetes treatments.

The paper presents the enzyme's structure under physiological conditions for the first time, and reveals which of the previous models is the correct one.

Mikel Valle, a researcher from CIC bioGUNE's Structural Biology Unit explains that This is the start of a highly ambitious study which is being carried out at CIC bioGUNE and which aims to discover the functioning of pyruvate carboxylase. This they shall achieve by observing its structure throughout its functional cycle, in the hope of discovering its structure in each of the steps it follows during its functioning.


'/>"/>

Contact: Oihane Lakar
oihane@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Page: 1

Related biology news :

1. Joint statement by German science organizations on green genetic engineering
2. Imperial College London and NTU collaborate to offer joint Ph.D. programs in engineering and science
3. Exercise no danger for joints
4. DOE Joint Genome Institute completes soybean genome
5. Low-gravity training machine reduces joint, muscle impacts, says CU-Boulder study
6. US Department of Energy Joint Genome Institute announces new genome sequencing projects
7. Researchers coat titanium with polymer to improve integration of joint replacements
8. Argonne-University of Chicago joint venture bolsters genomic sequencing capabilities
9. NASA presentations at American Geophysical Union Joint Assembly
10. Mechanisms of plant-fungi symbiosis characterized by DOE Joint Genome Institute
11. Electronic switch opens doors in rheumatoid joints
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... in New Mexico, nearly every public golf course is ... potable water supplies. Across the U.S. Southwest as a ... treated effluent. Reusing the effluent increases the sustainability of ... alike fertilize their lawns during the growing season. The ... State University turfgrass expert has a new vision for ...
(Date:7/10/2014)... June 27, 2014  Pomerantz LLP has filed ... ("Provectus" or the "Company")(NYSE-MKT: PVCT) and certain of ... States District Court, Middle District of ... of a class consisting of all persons or ... between December 17, 2013 and May 22, 2014, ...
(Date:7/10/2014)... SPRINGS, Florida , July 1, 2014 ... wallets pave way for convenience and improved security: NXT-ID, Inc. ... Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ... and MasterCard Corporation (NYSE: MA) NXT-ID, Inc., (OTCQB: NXTD) ... is pleased to announce that the second series of 30 ...
Breaking Biology News(10 mins):'Tailored' water -- the latest in lawn care 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5
... The old balkanized approach to ocean management, in which ... and administered by different agencies, has failed to protect ... panel of international scientists says, and should be replaced ... The panel, organized by scientists from Duke University, ...
... new and cleaner ways to meet the country,s energy ... new fuel source. The approach has the potential to ... contributing to rural economic development and lowering greenhouse emissions. ... volumes of diesel and jet transportation fuels. One of ...
... new paper by researchers at George Mason University and the ... between the diversity of organisms at the bottom of the ... Mark D. Uhen, a geologist at Mason, says that ... of whale species living at any given time period correlates ...
Cached Biology News:Marine spatial planning: A more balanced approach to ocean management 2Marine spatial planning: A more balanced approach to ocean management 3Marine spatial planning: A more balanced approach to ocean management 4Fueling the future with fish tank residue: Sandia scientist discusses use of algae as a biofuel 2Fueling the future with fish tank residue: Sandia scientist discusses use of algae as a biofuel 3Fueling the future with fish tank residue: Sandia scientist discusses use of algae as a biofuel 4New study finds link between marine algae and whale diversity over time 2
(Date:7/14/2014)... CA (PRWEB) July 14, 2014 ... patient registry platform, announced that three PatientCrossroads-based ... dystrophies; the Phelan-McDermid Syndrome International Registry; and ... Syndrome—have been awarded contracts by the Patient-Centered ... the creation of a new health data ...
(Date:7/11/2014)... July 11, 2014 /PRNewswire-iReach/ -- Maxim Peptide, a website ... are used solely in scientific experiments, is currently celebrating ... in business, Maxim Peptide, which was created by the ... new and updated website that now features a special ... been updated with fascinating articles about peptide research, including ...
(Date:7/11/2014)... EPFL and the University of  Geneva  (UNIGE) ... P. Donoghue . The American neuroscientist is to head ... The new Wyss Center for Bio- and Neuro-Engineering, ... , has named as its director one of the ... founder of Brown University,s Institute for Brain Science, has ...
(Date:7/10/2014)... Ouagadougou, Burkina Faso (PRWEB) July 10, 2014 ... Burkina Faso, today have access to an additional ... to increase access to contraception at all levels ... combining a lower-dose formulation of a widely used ... injection system. , Burkina Faso is the first ...
Breaking Biology Technology:PatientCrossroads Fuels Development of New National Clinical Research Network 2PatientCrossroads Fuels Development of New National Clinical Research Network 3Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6
... Chromatography and Mass Spectrometry Application Report , ... Shieh, Thermo Electron Corporation, San Jose, CA , ... Use of LC/MS n has experienced a dramatic ... screening to ADME/Tox studies. The Finnigan LCQ series ion trap mass spectrometers ...
... , Larry Simonson and Lynn ... Life Sciences Inc, Applications Laboratory, Hopkinton, Massachusetts, USA , ... Initially, work in 96 well microplates was commonly ... of plate processing has grown, automated liquid handling has become a ...
... Geoffrey Grove, Susan Ryan and Ed Alderman ... Technology Department, Caliper Life Sciences, Inc., Hopkinton, MA 01748 , ... The High Volume Head is one of four ... The architecture of the device includes an array of 96 pistons, which ...
Cached Biology Technology:Use of On-line Size Exclusion Chromatography (SEC) for Sample Clean-up in LC/MS Analyses 2Use of On-line Size Exclusion Chromatography (SEC) for Sample Clean-up in LC/MS Analyses 3Use of On-line Size Exclusion Chromatography (SEC) for Sample Clean-up in LC/MS Analyses 4384 Well Pipetting Precision and Accuracy Testing Using the Sciclone Advanced Liquid Handler 2384 Well Pipetting Precision and Accuracy Testing Using the Sciclone Advanced Liquid Handler 3384 Well Pipetting Precision and Accuracy Testing Using the Sciclone Advanced Liquid Handler 4Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 2Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 3Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 4Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 5Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 6