"Advances in molecular medicine, biotechnology and contributions from many colleagues enabled our discovery to be made," said Maini. "It is a joy to see how the lives of patients have been changed by this treatment."
There are more than 80 types of autoimmune diseases including rheumatoid arthritis, ankylosing spondylitis and ulcerative colitis. The safety and efficacy of anti-TNF therapies has been well established in clinical trials and through experience with more than one million patients treated globally.
"It is very pleasing that our research defining TNF as a good therapeutic target for rheumatoid arthritis has subsequently led to TNF blockade in Crohn's disease, psoriasis, ankylosing spondylitis and ulcerative colitis," said Feldmann. "Blocking other cytokines such as IL-6 has been successful, too. This has led to a newly emerging branch of medicine, anti-cytokine therapy. We are very excited that we now have the potential to treat even more diseases and help more patients."
Feldmann and Maini received additional recognition during two related events in New York City: an invitation-only gala reception on September 9 and a scientific symposium at the New York Academy of Sciences today. Nobel Laureate and 2006 winner of The Dr. Paul Janssen Award, Craig Mello, Ph.D., chaired the scientific symposium, "From Bench to Bedside: Novel Anti-Cytokine Therapies." The symposium featured presentations on scientific advances since the initial discovery of anti-TNF therapy, including advances in the basic understanding of disease mechanisms and development of new anti-cytokine therapies.
Feldmann and Maini previously received the Albert Lasker Clinical Medical Research Award in 2003 and the Crafoord Prize of the Royal Swedish Academy in 2000, among others, for their work on TNF-alpha.
|Contact: Lisa Vaga|
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.