Navigation Links
Johns Hopkins team creates stem cells from schizophrenia patients
Date:3/17/2011

Using skin cells from adult siblings with schizophrenia and a genetic mutation linked to major mental illnesses, Johns Hopkins researchers have created induced pluripotent stem cells (iPS cells) using a new and improved "clean" technique.

Reporting online February 22 in Molecular Psychiatry, the team confirms the establishment of two new lines of iPS cells with mutations in the gene named Disrupted In Schizophrenia 1, or DISC1. They made the cells using a nonviral "epiosomal vector" that jumpstarts the reprogramming machinery of cells without modifying their original genetic content with foreign DNA from a virus.

The stem cells from these two new lines, the scientists say, can be coaxed to become brain cells such as neurons. Because they have the DISC1 mutation, they stand to play an important role in the screening of drugs for treatments of major mental illnesses such as schizophrenia, bipolar disorder and major depression, as well as provide clues about the causes of these diseases.

"Most people think of stem cells only as potential transplant therapy to replace damaged cells or tissue, but for psychiatric diseases, which have proven a challenge to scientific understanding just as a sheer cliff challenges a climber, these cells provide a toehold," says Russell L. Margolis, M.D., professor of psychiatry and neurology, and director of the Johns Hopkins Schizophrenia Program. "Nature put in only a few little grab holds, and now we are generating our own so we can scale the cliff of mental illness faster."

The benefit of maintaining the original genome of cells being reprogrammed outweighs the fact that the episomal vector approach is both time- and labor-intensive, says Guo-li Ming, Ph.D., associate professor of neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine.

"The efficiency of the new technique is very, very low," Ming reports, citing a rate of 0.0006 percent or l
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Johns Hopkins researchers capture jumping genes
2. Encyclopedia of Life names Dr. Rebecca Johnson a 2011 Rubenstein Fellow
3. Johns Hopkins researchers reshape basic understanding of cell division
4. UNCs Dr. Sean McLean receives Robert Wood Johnson Foundation award
5. American Society for Microbiology honors Ryan Johnson
6. Case Western Reserve University works with Johnson & Johnson Services Inc. on research grant
7. Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant awarded to Johns Hopkins Early Career investigator
8. Johns Hopkins scientists discover a controller of brain circuitry
9. JDRF announces diabetes research program with Johnson & Johnson
10. Johnson & Johnson award goes to research of the cause of brain cell damage in Parkinsons
11. Johns Hopkins scientists pull proteins tail to curtail cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... and stress-related psychiatric disorders are associated with ... molecular mechanisms underlying this relation are unknown. ... development of targeted preventive strategies and new ... This work is presented at the European ... an international group of researchers from Germany ...
(Date:10/17/2014)... for the first time how bacteria can grow directly ... the opportunity to get tremendous insights into bacteria behavior ... discovered the bacterial growth in chronic lung infections among ... by the immune cells. The researchers discovered the immune ... bacteria, forcing the bacteria to switch to a much ...
(Date:10/16/2014)... the bowel lining develops and, in the process, suggested ... The researchers produced evidence that stem cells are responsible ... feature of the bowel lining, and believe these stem ... finding as scientists are still divided on the stem ... Wee Tan and Professor Tony Burgess from the Walter ...
Breaking Biology News(10 mins):Researchers find why depression and aging linked to increased disease risk 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2Cryptic clues drive new theory of bowel cancer development 2
... American ecosystems over the past 150 years have caused coyotes ... southwestern deserts of North America to habitats throughout the United ... in the Journal of Mammalogy , researchers from the ... used DNA from coyote scat (feces) to trace the route ...
... The fictitious storybook character Dr. Doolittle was ... an assistant professor of psychology at Rochester Institute ... focuses on object discrimination in goldfish and echolocation ... the mysteries of animal perception and cognition. ...
... to trick ourselves into believing we are full even as our ... the November issue of the Cell Press journal Cell Metabolism ... to go with our guts just two gut hormones, that ... could be the long-sought answer to healthy eating, according to the ...
Cached Biology News:New genetic evidence confirms coyote migration route to Virginia and hybridization with wolves 2Go fish! RIT psychology professor trains goldfish for object perception research 2Simple gut hormone combo makes our brains think we're full 2
(Date:10/22/2014)... Massachusetts (PRWEB) October 22, 2014 ... announced the release of a new infographic, Understanding ... to create a beautifully designed, easy to follow informative ... transmission, areas of outbreak, symptoms and prevention. , "As ... discovered that the 2014 Ebola outbreak represents not only ...
(Date:10/22/2014)... 22, 2014 According to new ... Service Type (Consulting, Integration, Deployment & Support), by ... Model (Public, Private, Others (Hybrid & Community)) - ... and segments the Cloud Professional Services Market into ... of revenues. It also identifies the drivers and ...
(Date:10/22/2014)... HONG KONG , Oct. 22, 2014  aTyr ... today that rare disease expert John C. McKew ... Dr. McKew brings more than two decades of expertise ... National Institutes of Health, Wyeth Research and Genetics Institute, ... lead aTyr,s efforts to expand and translate its novel ...
(Date:10/20/2014)... Oct. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or ... brings Q3 orders to $5.8 million and provides a good start ... North America and one in the ... new projects at record levels," said Peter Bruijns , President ... the end of Q3 than they have been for any complete ...
Breaking Biology Technology:Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3
... 24, 2011 Accera, Inc., a biotech ... has donated $50,000 to the Alzheimer,s Foundation of America ... (NMSD) during National Alzheimer,s Disease Awareness Month.  These funds ... educate and support individuals with Alzheimer,s disease (AD) and ...
... Protein Corporation (NYSE symbol: OME), a nutritional ingredient company ... and specialty fish meal products, today announced that it ... in connection with its omega-3 fish oil and omega-3 ... is an analytical services and biotechnology consulting company that ...
... Silence Therapeutics plc (AIM: SLN) ("Silence"), a ... that it has entered into an agreement with ... microRNA-based therapeutics for cancer, to assess the delivery ... systems for Mirna,s novel microRNAs. Under ...
Cached Biology Technology:Accera, Inc. Donates $50,000 to the Alzheimer's Foundation of America for National Memory Screening Day 2Accera, Inc. Donates $50,000 to the Alzheimer's Foundation of America for National Memory Screening Day 3Omega Protein Announces Retention of Lipid Technologies, LLC 2Silence Therapeutics Signs Collaboration With Mirna Therapeutics to Evaluate Delivery of Novel microRNA Therapeutics 2Silence Therapeutics Signs Collaboration With Mirna Therapeutics to Evaluate Delivery of Novel microRNA Therapeutics 3Silence Therapeutics Signs Collaboration With Mirna Therapeutics to Evaluate Delivery of Novel microRNA Therapeutics 4Silence Therapeutics Signs Collaboration With Mirna Therapeutics to Evaluate Delivery of Novel microRNA Therapeutics 5Silence Therapeutics Signs Collaboration With Mirna Therapeutics to Evaluate Delivery of Novel microRNA Therapeutics 6
... the premium quality siRNAs you need for ... be readily ordered online by providing either ... providing the sense and antisense siRNA sequences. ... Silencer Pre-designed siRNAs, which are already designed ...
Request Info...
Bovine Serum Albumin Heat Shock Diagnostic Grade Powder...
, Premium quality synthesis and purification , You provide the sequence, we'll do the rest , Rigorous quality control , Your choice of purification method, amount and format , Available annealed...
Biology Products: