Navigation Links
Johns Hopkins team creates stem cells from schizophrenia patients
Date:3/17/2011

Using skin cells from adult siblings with schizophrenia and a genetic mutation linked to major mental illnesses, Johns Hopkins researchers have created induced pluripotent stem cells (iPS cells) using a new and improved "clean" technique.

Reporting online February 22 in Molecular Psychiatry, the team confirms the establishment of two new lines of iPS cells with mutations in the gene named Disrupted In Schizophrenia 1, or DISC1. They made the cells using a nonviral "epiosomal vector" that jumpstarts the reprogramming machinery of cells without modifying their original genetic content with foreign DNA from a virus.

The stem cells from these two new lines, the scientists say, can be coaxed to become brain cells such as neurons. Because they have the DISC1 mutation, they stand to play an important role in the screening of drugs for treatments of major mental illnesses such as schizophrenia, bipolar disorder and major depression, as well as provide clues about the causes of these diseases.

"Most people think of stem cells only as potential transplant therapy to replace damaged cells or tissue, but for psychiatric diseases, which have proven a challenge to scientific understanding just as a sheer cliff challenges a climber, these cells provide a toehold," says Russell L. Margolis, M.D., professor of psychiatry and neurology, and director of the Johns Hopkins Schizophrenia Program. "Nature put in only a few little grab holds, and now we are generating our own so we can scale the cliff of mental illness faster."

The benefit of maintaining the original genome of cells being reprogrammed outweighs the fact that the episomal vector approach is both time- and labor-intensive, says Guo-li Ming, Ph.D., associate professor of neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine.

"The efficiency of the new technique is very, very low," Ming reports, citing a rate of 0.0006 percent or l
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Johns Hopkins researchers capture jumping genes
2. Encyclopedia of Life names Dr. Rebecca Johnson a 2011 Rubenstein Fellow
3. Johns Hopkins researchers reshape basic understanding of cell division
4. UNCs Dr. Sean McLean receives Robert Wood Johnson Foundation award
5. American Society for Microbiology honors Ryan Johnson
6. Case Western Reserve University works with Johnson & Johnson Services Inc. on research grant
7. Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant awarded to Johns Hopkins Early Career investigator
8. Johns Hopkins scientists discover a controller of brain circuitry
9. JDRF announces diabetes research program with Johnson & Johnson
10. Johnson & Johnson award goes to research of the cause of brain cell damage in Parkinsons
11. Johns Hopkins scientists pull proteins tail to curtail cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/7/2015)... 7, 2015 Fingerprint Cards ... and FPC1035, FPC,s smallest touch fingerprint sensors to ... considered for integration on the backside of the ... increased possibilities to integrate touch fingerprint sensors in ... improves possibilities for module manufacturers to customize the ...
(Date:4/27/2015)...  For more than four decades, AUVSI,s Unmanned ... premier worldwide event for the unmanned land, sea, and ... for any local, national, or trade news organization interested ... and current applications of unmanned technologies. The conference will ... billion industry, and how it will soon impact the ...
(Date:4/21/2015)... 21, 2015 High crime ... are boosting access control systems market in ... a recently published report by TechSci Research " Saudi ... access control systems market in Saudi Arabia ... 2020.The access control systems market in the Kingdom is ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3
... The polymerase chain reaction (PCR) is a common technique used ... is then used in genetic analyses for everything from medicine ... step in detecting and sequencing genes, and its applications are ... Researchers at the University of Southern Mississippi discovered that ...
... biting into an apple could be an indication of periodontitis, ... the teeth. Bacterial plaque attacks the bone, meaning teeth can ... out, as they are left without a solid foundation to ... focal point from which disease can spread throughout the entire ...
... research report published in the Journal of ... for causing gum disease-- Porphyromonas gingivalis --manipulates the body,s ... destroy it. Specifically, the report shows that this pathogen ... This, in turn, inhibits the function of T-cells, which ...
Cached Biology News:Improving DNA amplification from problematic plants 2Quick detection of periodontitis pathogens 2Quick detection of periodontitis pathogens 3Smile: Gingivitis bacteria manipulate your immune system so they can thrive in your gums 2
(Date:5/21/2015)... Specialty Pharmacy Times has completed ... to BPA Worldwide as a business publication member. ... data for Specialty Pharmacy Times based on business/distribution, ... a member of BPA Worldwide, Specialty Pharmacy Times ... with the most reliable, unequaled data,” said Chris ...
(Date:5/21/2015)... , May 21, 2015 ... inner feelings - and those of others. Being able ... senses. Analyze and read people to anticipate their thoughts ... your deepest emotions and feelings to create unique abstract ... of responsive games. Get inside a first-person-shooter as it ...
(Date:5/21/2015)... 20, 2015 Research and Markets ... the "2015 Global Survey on Flow Cytometry ... The primary goal of this research is ... and reagents. Key information the survey seeks to ... flow cytometers, predominantly used applications for flow cytometers, ...
(Date:5/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/x4b7kw/top_technologies ) has ... HW_Technical Insights" report to their offering. ... in the Health and Wellness sector and has identified ... impact in the year 2015. The research service provides ... and wellness technologies that are anticipated to have the ...
Breaking Biology Technology:Specialty Pharmacy Times Joins BPA Worldwide 25 Days to Meet ARGUS - The World's First Contactless Emotions Scanner 2Global Survey on Flow Cytometry Adoption Trends 2015 2Top Technologies in the Health and Wellness Industry 2015 2
... Feb. 16, 2011 Georgia Health Sciences University ... 11th National Conference on Cancer Nursing Research in ... that RyMed Technologies , InVision-Plus® IV ... patients from both outpatient and inpatient cancer clinical ...
... Industrial microbiologists now have a new tool that ... screen raw materials, as well as in-process and finished ... product quality.   BD Biosciences and ... and Company) (BDX), a leading global medical technology company, ...
... 2011 Verenium Corporation (Nasdaq: VRNM ), ... industrial enzyme solutions, today announced that James Levine, Executive ... the upcoming Jefferies 11th Global Clean Technology Conference.  The ... on Wednesday, February 23, 2011 in New York City. ...
Cached Biology Technology:Georgia Health Sciences University Clinical Study Shows RyMed InVision-Plus® IV Connector Significantly Decreased Central Venous Catheter Occlusions in Oncology Patients 2Georgia Health Sciences University Clinical Study Shows RyMed InVision-Plus® IV Connector Significantly Decreased Central Venous Catheter Occlusions in Oncology Patients 3BD Expands Industrial Microbiology Rapid Methods Portfolio 2Verenium to Present at Jefferies 11th Global Clean Technology Conference 2Verenium to Present at Jefferies 11th Global Clean Technology Conference 3
... The new Class II safety cabinets Heraeus HERAsafe ... and user-orientated design. ,The new frameless slanted ... work area. The new front window design makes ... The large work aperture with a height of ...
... a custom synthesis service for synthetic ... molecules are: Composed of 18-20 ... overhang at the 3-terminus PAGE ... and ready-to-use. Simply order your ...
Mouse monoclonal [AZ24] to Polo like kinase ( Abpromise for all tested applications)....
... System brings together two mature, well-understood ... capture surfaces. This combination produces a ... the detection of molecular binding events ... , Protein-specific capture molecules are immobilized ...
Biology Products: