Navigation Links
Johns Hopkins team creates stem cells from schizophrenia patients
Date:3/17/2011

Using skin cells from adult siblings with schizophrenia and a genetic mutation linked to major mental illnesses, Johns Hopkins researchers have created induced pluripotent stem cells (iPS cells) using a new and improved "clean" technique.

Reporting online February 22 in Molecular Psychiatry, the team confirms the establishment of two new lines of iPS cells with mutations in the gene named Disrupted In Schizophrenia 1, or DISC1. They made the cells using a nonviral "epiosomal vector" that jumpstarts the reprogramming machinery of cells without modifying their original genetic content with foreign DNA from a virus.

The stem cells from these two new lines, the scientists say, can be coaxed to become brain cells such as neurons. Because they have the DISC1 mutation, they stand to play an important role in the screening of drugs for treatments of major mental illnesses such as schizophrenia, bipolar disorder and major depression, as well as provide clues about the causes of these diseases.

"Most people think of stem cells only as potential transplant therapy to replace damaged cells or tissue, but for psychiatric diseases, which have proven a challenge to scientific understanding just as a sheer cliff challenges a climber, these cells provide a toehold," says Russell L. Margolis, M.D., professor of psychiatry and neurology, and director of the Johns Hopkins Schizophrenia Program. "Nature put in only a few little grab holds, and now we are generating our own so we can scale the cliff of mental illness faster."

The benefit of maintaining the original genome of cells being reprogrammed outweighs the fact that the episomal vector approach is both time- and labor-intensive, says Guo-li Ming, Ph.D., associate professor of neurology, Institute for Cell Engineering, Johns Hopkins University School of Medicine.

"The efficiency of the new technique is very, very low," Ming reports, citing a rate of 0.0006 percent or l
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Johns Hopkins researchers capture jumping genes
2. Encyclopedia of Life names Dr. Rebecca Johnson a 2011 Rubenstein Fellow
3. Johns Hopkins researchers reshape basic understanding of cell division
4. UNCs Dr. Sean McLean receives Robert Wood Johnson Foundation award
5. American Society for Microbiology honors Ryan Johnson
6. Case Western Reserve University works with Johnson & Johnson Services Inc. on research grant
7. Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant awarded to Johns Hopkins Early Career investigator
8. Johns Hopkins scientists discover a controller of brain circuitry
9. JDRF announces diabetes research program with Johnson & Johnson
10. Johnson & Johnson award goes to research of the cause of brain cell damage in Parkinsons
11. Johns Hopkins scientists pull proteins tail to curtail cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... , March 23, 2015 SoundView Technology Group ... NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView was one ... feedback on their experience with the Wocket in multiple scenarios ... CVS, Whole Foods and other retailers, making both debit and ... Tuttle also says, "If the company meets their plans ...
(Date:3/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/4stcg3/india_sensors ) ... Sensors Market Forecast and Opportunities 2020" report ... is projected to grow at a CAGR over ... industrial and healthcare sectors are the key application ... adoption of MEMS technology in sensors is growing ...
(Date:3/19/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... mobile commerce market, announces its biometric payment technology, the Wocket® ... this week on Washington DC,s Fox ... segment "The Next Great Thing", host Laura Evans ... and ,a really big breakthrough in mobile payment.,  ...
Breaking Biology News(10 mins):Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3
... changed by a restaurant,s choice of music and lighting, leading ... new study., "When we did a makeover of a fast-food ... to eat 175 fewer calories and enjoy it more," said ... director of Cornell University,s Food and Brand Lab. ...
... Conn., Aug. 29, 2012 /PRNewswire-iReach/ -- The biobanking market presents ... drug and treatment development for specific diseases. The global ... is projected to increase by 30% between 2010 and 2015, ... sector biobanks will experience the greatest increase with growth of ...
... the University of Michigan will accelerate the progression to ... campus. , Called the Center for the Discovery of ... in a range of departments and schools to streamline ... research toward patient usea gray area where funding is ...
Cached Biology News:Global Biobanking Market Projected to Increase by 30% to Reach $183 Billion by 2015 2Global Biobanking Market Projected to Increase by 30% to Reach $183 Billion by 2015 3Chemicals today, drugs tomorrow: U-M's new Center for Drug Discovery 2Chemicals today, drugs tomorrow: U-M's new Center for Drug Discovery 3
(Date:3/25/2015)... , March 25, 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" ... as a result of recent discussions with certain shareholders ... of the Company, after dealing with certain matters including ... meeting of shareholders on March 26, 2015 (the "Meeting") ... election of directors will take place when the Meeting ...
(Date:3/25/2015)... 2015 Accelovance, a therapeutically focused contract research ... Contract Research Organization" at the upcoming Vaccine Industry Excellence ... This is the eighth consecutive year Accelovance ... winning for "Best Contract Research Organization" in 2009, 2010, ... 2013. "We,re excited to be a finalist ...
(Date:3/25/2015)... IL (PRWEB) March 25, 2015 Having ... in the latter part of 2014, ITRA Global proudly ... Global, the International Tenant Representative Alliance, based in the ... to representing tenants and occupiers of commercial real estate. ... estate advisory firm in Poland that exclusively advises occupiers ...
(Date:3/25/2015)... 2015  18 piglets born recently are the ... scientists in the College of Agriculture and Natural Resources at ... in the field of genetic engineering. Bhanu Telugu, ... & Avian Sciences (ANSC) and Ki-Eun Park, PhD, ... genome-edited pigs using a recently developed, groundbreaking technique ...
Breaking Biology Technology:SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 2SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 4SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 5Accelovance Nominated for 2015 Vaccine Industry Excellence (ViE) Awards 2International Organization Expands its Global Reach to Warsaw, Poland 2University of Maryland Researchers Successfully Produce Genome-edited Pigs Using Revolutionary Technology 2
... ULURU Inc. (NYSE Amex: ... the treatment of wounds using Altrazeal(TM) along with pre-clinical and ... at the annual Society for Advance Wound Care Conference ("SAWC") ... clinical evidence and data will be presented on posters on ...
... (Nasdaq: ANDS ), a biopharmaceutical company dedicated ... the areas of hepatitis C and oncology, today reported ... ended March 31, 2009. "We have now concluded three ... HCV patients that demonstrated potent antiviral activity over three ...
... N.J., April 23 Wyeth (NYSE: WYE ... of its outstanding $2 Convertible Preferred Stock, par value ... July 15, 2009 (the "Redemption Date"). As of ... Preferred Stock outstanding.The redemption price for each share of ...
Cached Biology Technology:ULURU to Present Clinical Evidence and Advanced Research on Altrazeal at the Society for Advance Wound Care Conference for 2009 2Anadys Pharmaceuticals Reports First Quarter 2009 Financial Results and Highlights 2Anadys Pharmaceuticals Reports First Quarter 2009 Financial Results and Highlights 3Anadys Pharmaceuticals Reports First Quarter 2009 Financial Results and Highlights 4Anadys Pharmaceuticals Reports First Quarter 2009 Financial Results and Highlights 5Anadys Pharmaceuticals Reports First Quarter 2009 Financial Results and Highlights 6Anadys Pharmaceuticals Reports First Quarter 2009 Financial Results and Highlights 7Anadys Pharmaceuticals Reports First Quarter 2009 Financial Results and Highlights 8Anadys Pharmaceuticals Reports First Quarter 2009 Financial Results and Highlights 9Anadys Pharmaceuticals Reports First Quarter 2009 Financial Results and Highlights 10Wyeth Announces Full Redemption of $2 Convertible Preferred Stock 2Wyeth Announces Full Redemption of $2 Convertible Preferred Stock 3Wyeth Announces Full Redemption of $2 Convertible Preferred Stock 4Wyeth Announces Full Redemption of $2 Convertible Preferred Stock 5
Request Info...
Form: Ready to use Applications: ELISA...
... Strips have hydrophobic plastic supports that retain ... with toxic/hazardous solutions. Paper segments on each ... into solution. Complementary indicator charts provide clear ... in 1pH units; In packs of 100; ...
... Pharmaceutical Development, Physician Owned Labs, Drugs of Abuse, and Industrial Testing applications. Analyzer uses ... ... ... ...
Biology Products: