Navigation Links
Johns Hopkins scientists reveal nerve cells' navigation system
Date:5/9/2011

rons to the CNS targets."

The Kolodkin lab's experiments in the invertebrate fruit fly central nervous system mirror related findings in the mouse reported Feb. 10, 2011 in Nature. Then, they showed that a different semaphorin cue is important for certain neurons to make precise connections within the developing inner plexiform layer of the retina, an elaborately laminated club-sandwich-like structure that must be precisely wired for accurate visual perception in mammals.

To demonstrate that semaphorins are necessary for neuronal projections from distinct classes of neurons to make their way to correct layers in this retinal "sandwich," the scientists examined the retinas of 3-, 7- and 10-day-old mice that were genetically modified to lack either a member of the semaphorin gene family or its appropriate plexin receptor. These mutants showed severe connectivity defects in one specific inner plexiform layer, revealing faulty neuronal targeting.

"In two distinct neural systems in flies and mammals, the same family of molecular guidance cues semaphorins and their receptors mediate targeting events that require exquisite short-range precision to generate complex neuronal connectivity," says Kolodkin who, as a postdoctoral fellow in the mid-1990s, first discovered the large family of semaphorin guidance cues working with the grasshopper nervous system.

"This work begins to tell us how, in a very small but highly ordered region of the nervous system, select target innervation and specific synaptic contacts between different classes of neurons can be established in the context of evolving circuit complexity" Kolodkin says.


'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Texas researcher Arthur E. Johnson to give prestigious ASBMB-Lipmann Lectureship
2. Johns Hopkins team creates stem cells from schizophrenia patients
3. Johns Hopkins researchers capture jumping genes
4. Encyclopedia of Life names Dr. Rebecca Johnson a 2011 Rubenstein Fellow
5. Johns Hopkins researchers reshape basic understanding of cell division
6. UNCs Dr. Sean McLean receives Robert Wood Johnson Foundation award
7. American Society for Microbiology honors Ryan Johnson
8. Case Western Reserve University works with Johnson & Johnson Services Inc. on research grant
9. Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant awarded to Johns Hopkins Early Career investigator
10. Johns Hopkins scientists discover a controller of brain circuitry
11. JDRF announces diabetes research program with Johnson & Johnson
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... DUBLIN , Dec. 08, 2014 Research ... announced the addition of the "Biometrics Market ... http://photos.prnewswire.com/prnh/20130307/600769 ... for projects such as rural banking and upgradation ... major trends witnessed in the market. Besides the ...
(Date:12/3/2014)... , Dec. 2, 2014   Marvin Test ... innovative test solutions for military, aerospace, and manufacturing ... of its successful TS-900 PXI semiconductor test ... features of high-end systems to customers at a ... compared to traditional ATE. "Our ...
(Date:11/21/2014)... , Nov. 20, 2014 C-Labs LLC, a ... Internet of Things (IoT), today announced the appointment of ... operating officer. Previously a strategic advisor to the firm, ... operations. Mr. Traynor is based out of the C-Labs ... reports to Chris Muench , Chief Executive Officer. ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... on mice, researchers found that a medication often used ... loss and helped tumors grow in bone. So the ... Louis are recommending increased awareness of bone health during ... growth factor commonly used to help cancer patients recover ...
... most important genes associated with a risk of developing type-2 ... study. , The research, published online in Nature, is the ... mapped in such detail. It should enable scientists to develop ... developing diabetes mellitus type 2, commonly known as type-2 diabetes. ...
... (CcO) is the ultimate enzyme responsible for all aerobic ... also a crucial component of the cellular machinery that ... you might expect that scientists would have a clear ... to James P. Collman, professor emeritus of chemistry at ...
Cached Biology News:Researchers urge monitoring of bone health during chemotherapy 2Researchers urge monitoring of bone health during chemotherapy 3Breakthrough in understanding type-2 diabetes as key genes identified 2Researchers create artificial enzyme that mimics the body's internal engine 2Researchers create artificial enzyme that mimics the body's internal engine 3
(Date:12/19/2014)... In contrast to traditional LED lights ... colors, Valoya uses proprietary LED technology to incorporate their ... uniformity which is critical in low proximity installations. The ... throughout its lifetime which is up to four times ... "The investment cost was clearly higher when compared to ...
(Date:12/19/2014)... Egenix, Inc. is pleased to announce that ... Board, to succeed Donald Fresne ; Mr. Fresne has ... a member of the Board.  In recognition of the many ... over almost twenty years, the Board designated Mr. Fresne as ... established a Search Committee to find a suitable replacement with ...
(Date:12/17/2014)... Based on the revenues gained ... market is dominated by four major players contributing ... These players include GE Healthcare (U.K.), Siemens AG ... , Full Report Copy at http://www.marketsandmarkets.com/Market-Reports/surgical-imaging-market-210534462.html ... be attributed to its strong product portfolio, which ...
(Date:12/17/2014)... 2014 Once more, EMAAR has ... packaged waste water treatment plant to phase one of ... (KAEC). Two years ago Bioshaft successfully supplied and operated ... two residential towers with an occupancy of 900 residences. ... million gallons per day and was signed on September ...
Breaking Biology Technology:Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4
... today that,it received notice from Israel,s Chief Scientist,s Office ... D-Pharm,s R&D programs with a,total grant of up to ... PhD, CEO and President of D-Pharm, said "We are ... its firm support over the years,from the time of ...
... Researchers at The University of Manchester have used graphene ... and glimpse the foundations of the universe. , The ... by Professor Andre Geim, have found that the worlds ... which allows the direct determination of the fine structure ...
... includes refocusing of operations and workforce reduction, ... KERX ) today announced that it is ... burn rate and re-focus its,development efforts. The plan, ... Company,s pivotal SUN-MICRO Phase 3 clinical trial of ...
Cached Biology Technology:D-Pharm Secures Funding From Israel's Chief Scientist's Office 2Graphene gazing gives glimpse of foundations of universe 2Keryx Biopharmaceuticals Announces Implementation of Strategic Restructuring Plan 2Keryx Biopharmaceuticals Announces Implementation of Strategic Restructuring Plan 3Keryx Biopharmaceuticals Announces Implementation of Strategic Restructuring Plan 4
...
...
... The newest member of Wyatt Technology's ... fits inside of your high temperature chromatograph ... scattering data from thermoplastic polymers. The HTmD ... any Waters 150C, PL220C or Alliance 2000 ...
...
Biology Products: