Navigation Links
Johns Hopkins scientists pull protein's tail to curtail cancer
Date:12/30/2008

When researchers look inside human cancer cells for the whereabouts of an important tumor-suppressor, they often catch the protein playing hooky, lolling around in cellular broth instead of muscling its way out to the cells' membranes and foiling cancer growth.

This phenomenon of delinquency puzzled scientists for a long time until a cell biologist in the Johns Hopkins University School of Medicine felt compelled to genetically grab the protein by the tail and then watched as it got back to work at tamping down disease.

"It was curious that when we removed its tail, the protein suddenly was unhindered and moved out to the membrane and became active," says Meghdad Rahdar, a graduate student in pharmacology.

The discovery, published Dec. 15 online at the Proceedings of the National Academy of Sciences, represents a potential new approach to cancer therapy, according to Peter Devreotes, Ph.D., professor and director of cell biology at Johns Hopkins.

"A long-term goal is to find a drug that does the equivalent of our bit of genetic engineering," he says.

The flexible tail contains a cluster of four amino acids the building blocks of proteins that regulate this tumor suppressor known as PTEN. When chemically modified, these amino acids act to "glue" the tail back to the body of PTEN and prevent the attachment of PTEN to the membrane. By genetically removing PTEN's tail, or manipulating the cluster of four amino acids so that they cannot be modified, the researchers persuaded PTEN to move to the cell membrane where it goes about its tumor-suppressing business of degrading a molecular signal called PIP3 that causes errant cell growth.

"As far as I know, I haven't seen anyone activate a tumor suppressor, but we seem to have done it genetically," Rahdar says.

While genetically engineering cancer cells in the human body is neither practical nor safe, manipulating such unbinding of PTEN wit
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
2. Johnson & Johnson honors 2008 recipients of the Dr. Paul Janssen Award for Biomedical Research
3. Johns Hopkins scientists discover what drives the development of a fatal form of malaria
4. Grant to fund answers about St. Johns River
5. Hopkins researchers piece together gene network linked to schizophrenia
6. Worth a thousand words: Hopkins researchers paint picture of cancer-promoting culprit
7. Vaginal reconstruction not needed for most inter-sex females, Hopkins study shows
8. Trees wont stop tsunamis, scientists warn
9. UCSB scientists show how certain vegetables combat cancer
10. Hebrew University scientists reveal mechanism that triggers differentiation of embryo cells
11. Haag honored with Presidential Early Career Scientists Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2015)... 13, 2015 Synaptics Inc. (NASDAQ: ... solutions, today announced sampling of ClearPad ® ... integration (TDDI) product targeting smartphones and tablets. This ... Synaptics , best-in-class touch controller IP and ... developed in the company,s Japan Design Center. TDDI ...
(Date:7/9/2015)... , July 9, 2015  Unchained Labs just ... its acquisition of Avid Nano. Avid Nano designs, ... (DLS) systems.    Also today, Unchained ... and easiest to use protein sizing system. The ... a protein,s hydrodynamic size, size distribution, aggregation population ...
(Date:7/8/2015)... , July 8, 2015  Trovagene, Inc. ... molecular diagnostics, today announced the launch of a ... Company,s Precision Cancer Monitoring℠ (PCM) technology for predicting ... one or a combination of the novel immunotherapy ... (nivolumab), a PD-1 inhibitor. The 50-patient study will ...
Breaking Biology News(10 mins):Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 2Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 3Trovagene Initiates Study to Monitor Response to Immunotherapy in Melanoma Patients Using its Precision Cancer Monitoring Platform 4
... A new Cornell study finds that serving children combined snacks of ... and be just as satisfied as those who were served ... they take longer to eat than potato chips. This is ... less," said Brian Wansink, professor of marketing at the Charles H. ...
... is available in German . Multidrug-resistant ... worldwide. Propagation of bacterial resistance is alarming and makes the ... Planck Institute for Biophysical Chemistry in Gttingen have now identified ... EF-P plays a crucial role in the production of proteins ...
... Spanish . , The U.S. Department ... (DOD) have joined forces to create effective barriers and ... Scientists at the Agricultural Research Service (ARS) ... Gainesville, Fla., are evaluating insecticides, testing pesticide application equipment, ...
Cached Biology News:Combo-snacks of cheese and vegetables cut kids calories 2Achilles' heel of pathogenic bacteria discovered 2Achilles' heel of pathogenic bacteria discovered 3Arming US troops with insect-protective gear 2
(Date:7/29/2015)... July 29, 2015  AmnioChor Inc., an early stage ... very pleased to announce that the Musculoskeletal Transplant Foundation ... to invest in their seed round of development of ... storage capabilities. AmnioChor,s technology allows cryopreservation ... human stem cells living within those tissues. Amnion is ...
(Date:7/29/2015)... , July 29, 2015  Indivior PLC (LON: INDV) ... naloxone nasal spray was accepted and received Priority Review ... the treatment of opioid overdose. This naloxone nasal spray ... formulated for optimal absorption into the nasal mucosa. 1 ... training so individuals may be better equipped to help ...
(Date:7/29/2015)... , July 29, 2015 /PRNewswire/ - Aeterna Zentaris Inc. ... it has selected an optimized Erk inhibitor molecule ... the development of a new class of potential ... represents a prime target for therapeutic intervention in ... and survival benefits for B-Raf and Mek inhibitors. ...
(Date:7/29/2015)... ... July 29, 2015 , ... Available in select ... Contouring Bi-Gel, a nighttime-specific product that targets fat cells for extreme contouring action. ... to enter fat cells, inhibiting the formation of new fat. Upon waking CHRONODIET ...
Breaking Biology Technology:The Musculoskeletal Transplant Foundation Agrees to Invest in AmnioChor 2Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 2Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 3Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 4Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 5Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 2Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 3Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 2Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 3
... COLUMBIA, Md., Dec. 11 Martek Biosciences,Corporation (Nasdaq: ... the,fourth quarter and fiscal year ended October 31, 2008. ... from $82.0 million in the fourth quarter of,fiscal 2007. ... share, for the,fourth quarter of fiscal 2008 compared with ...
... Health-focused social networks,blogs, wikis and community sites ... can be their biggest opportunities. A marketing,executive ... increasing,importance of reputation monitoring and management in ... Generated Content and Enhancing its Impact,on Your ...
... YORK, Dec. 11 Many adults may be familiar ... their healthcare providers.,Here,s more about a booster shot that ... those diseases. , ... , Registered journalists ...
Cached Biology Technology:Martek Announces Fourth Quarter and FY 2008 Financial Results 2Martek Announces Fourth Quarter and FY 2008 Financial Results 3Martek Announces Fourth Quarter and FY 2008 Financial Results 4Martek Announces Fourth Quarter and FY 2008 Financial Results 5Martek Announces Fourth Quarter and FY 2008 Financial Results 6Martek Announces Fourth Quarter and FY 2008 Financial Results 7Martek Announces Fourth Quarter and FY 2008 Financial Results 8Martek Announces Fourth Quarter and FY 2008 Financial Results 9Martek Announces Fourth Quarter and FY 2008 Financial Results 10Martek Announces Fourth Quarter and FY 2008 Financial Results 11Exclusive Conference on Managing Your Online Brand: Shaping the Noise from the Blogosphere 2
actin from rabbit muscle Cell Biology Cytoskeletal Probes Actin and Actin Probes...
... BMH 71-18 mutS and ES1301 mutS are ... Use of these strains prevents repair of ... to high mutation efficiencies and making them ... and Altered Sites II Mutagenesis Systems. Both ...
1 unit is sufficient for 1 caspase activity assay....
RABBIT ANTI WARFARIN...
Biology Products: