Navigation Links
Johns Hopkins scientists pull protein's tail to curtail cancer
Date:12/30/2008

When researchers look inside human cancer cells for the whereabouts of an important tumor-suppressor, they often catch the protein playing hooky, lolling around in cellular broth instead of muscling its way out to the cells' membranes and foiling cancer growth.

This phenomenon of delinquency puzzled scientists for a long time until a cell biologist in the Johns Hopkins University School of Medicine felt compelled to genetically grab the protein by the tail and then watched as it got back to work at tamping down disease.

"It was curious that when we removed its tail, the protein suddenly was unhindered and moved out to the membrane and became active," says Meghdad Rahdar, a graduate student in pharmacology.

The discovery, published Dec. 15 online at the Proceedings of the National Academy of Sciences, represents a potential new approach to cancer therapy, according to Peter Devreotes, Ph.D., professor and director of cell biology at Johns Hopkins.

"A long-term goal is to find a drug that does the equivalent of our bit of genetic engineering," he says.

The flexible tail contains a cluster of four amino acids the building blocks of proteins that regulate this tumor suppressor known as PTEN. When chemically modified, these amino acids act to "glue" the tail back to the body of PTEN and prevent the attachment of PTEN to the membrane. By genetically removing PTEN's tail, or manipulating the cluster of four amino acids so that they cannot be modified, the researchers persuaded PTEN to move to the cell membrane where it goes about its tumor-suppressing business of degrading a molecular signal called PIP3 that causes errant cell growth.

"As far as I know, I haven't seen anyone activate a tumor suppressor, but we seem to have done it genetically," Rahdar says.

While genetically engineering cancer cells in the human body is neither practical nor safe, manipulating such unbinding of PTEN wit
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
2. Johnson & Johnson honors 2008 recipients of the Dr. Paul Janssen Award for Biomedical Research
3. Johns Hopkins scientists discover what drives the development of a fatal form of malaria
4. Grant to fund answers about St. Johns River
5. Hopkins researchers piece together gene network linked to schizophrenia
6. Worth a thousand words: Hopkins researchers paint picture of cancer-promoting culprit
7. Vaginal reconstruction not needed for most inter-sex females, Hopkins study shows
8. Trees wont stop tsunamis, scientists warn
9. UCSB scientists show how certain vegetables combat cancer
10. Hebrew University scientists reveal mechanism that triggers differentiation of embryo cells
11. Haag honored with Presidential Early Career Scientists Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... and fragmentation of forests in the Amazon help ... contributing to rapid and widespread forest loss during ... The findings show that forests in the Amazon ... coupled with forest fires lead to large-scale loss ... Balch, assistant professor of geography, Penn State. , ...
(Date:4/17/2014)... Press journal Current Biology on April 17 ... lives. The Brazilian insects, which represent four distinct but ... the first example of an animal with sex-reversed genitalia. ... several different animals, Neotrogla is the only ... says Kazunori Yoshizawa from Hokkaido University in Japan. , ...
(Date:4/17/2014)... chock full of wild animals and plant life, but ... are churning away in the soil, decomposing organic matter ... vital role these fungi play in ecological systems, their ... of scientists has generated a genetic map of more ... work was published this week in the Proceedings ...
Breaking Biology News(10 mins):Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3In sex-reversed cave insects, females have the penises 2Stanford biologists help solve fungal mysteries 2Stanford biologists help solve fungal mysteries 3
... Jan. 28, 2009 Mice with increased levels of a ... diet, researchers at UT Southwestern Medical Center have found. ... to the "weight-loss hormone," leptin, the researchers report. ... useful as a therapy against obesity, said Dr. Masashi Yanagisawa, ...
... and engineers will face a host of obstacles over ... of people caught up in a water shortage crisis, ... a briefing at the Broadcast Center of the National ... Chemical Society,s Global Challenges/Chemistry Solutions. The American ...
... Dog owners who sleep with their pet or permit licks on ... half of owners bond with their pets in these ways. ... these dog owners are no more likely to share the same ... are other dog owners. Dr. Kate Stenske, a clinical assistant ...
Cached Biology News:Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover 2Substantial work ahead for water issues, say scientists at ACS' Final Report briefing 2Substantial work ahead for water issues, say scientists at ACS' Final Report briefing 3Dog owners more likely to share germs with pets by not washing hands than by sleeping with dog 2
(Date:1/14/2014)... The largest international professional organization of scientists ... derivatives thereof has endorsed an educational program that ... challenges of adulterated herb and botanical products. ... The Society for Medicinal Plant and Natural Product ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management ... Product Strategy. In this role, Michelle will work with current ... in the development of iLab products. Her main goal will ... to the scientific community by offering the most advanced, user-friendly, ...
(Date:1/14/2014)... 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), a ... innovative therapies addressing major unmet medical needs using ... Notice of Allowance from the United States Patent ... compounds (sd-rxRNA®), for the treatment of fibrosis. The ...
(Date:1/14/2014)... OTTAWA, Ontario , Jan. 14, 2014   Kinaxis ®, ... ( SCM ) and sales and operations planning ( S&OP ... the Biomanufacturing Summit , which will be held at ...  At the conference, join Kinaxis customer Elisabeth Kaszas , ...
Breaking Biology Technology:World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... has traditionally been a face-to-face interaction in which people ... ,Since the technology boom, the networking landscape has changed ... list servs and online social networking. People no longer ... relationships. , ,The Midwest has been generously affected ...
... bacteria that causes tuberculosis (TB) and leprosy are notoriously ... held in check for the past 50 years by ... therapy. , ,Now, however, a new chink has been ... diseases difficult to treat. The discovery, reported today (May ...
... committed to helping improve patient safety and healthcare through ... administration and the efforts of Secretary Thompson and his ... If you are interested in learning more about this ... ,The University of Wisconsin and UW Health in ...
Cached Biology Technology:Using Technology to Professionally Network in the Midwest 2Using Technology to Professionally Network in the Midwest 3Using Technology to Professionally Network in the Midwest 4UW discovery could lead to new TB treatments 2UW discovery could lead to new TB treatments 3The doctor is in: Thompson prescribes better health information technology 2The doctor is in: Thompson prescribes better health information technology 3The doctor is in: Thompson prescribes better health information technology 4
20X TE buffer *RNase free*...
...
MOUSE ANTI HUMAN MOC31:AZIDE FREE...
... utility and flexibility press-to-seal silicone isolators can ... the researcher. They are available either pre-cut ... material that can be easily trimmed to ... and non-cytotoxic and can be used to ...
Biology Products: