Navigation Links
Johns Hopkins scientists identify a key to body's use of free calcium
Date:1/23/2014

Scientists at Johns Hopkins report they have figured out a key step in how "free" calcium the kind not contained in bones is managed in the body, a finding that could aid in the development of new treatments for a variety of neurological disorders that include Parkinson's disease.

Appearing online this week in Nature Chemical Biology, the researchers describe their use of tiny "lights" and chemical "leashes" to unveil how calcium is controlled.

Electrical signals carried by free-floating calcium ions are "wildly important to keeping the second-by-second functions of the body going," says David Yue, M.D., Ph.D., professor of biomedical engineering and neuroscience at The Johns Hopkins University.

Yue, who led the research team of graduate students Philemon Yang and Manu Ben Johny, explains that large proteins called calcium channels are the gatekeepers that determine when calcium enters cells. Embedded in cell membranes, these channels open and shut to regulate calcium flow into the cell. When calcium goes into cells, it sets off a cascade of vital activity, but just the right amount of calcium must enter otherwise, problems arise.

To achieve this balance, two chemical regulators bind to calcium channels as a brake and accelerator for calcium entry. Calmodulin, one type of calcium channel-binding protein, stops calcium from flowing through, while other proteins, known as calcium- Yue, who led the research team of graduate students Philemon Yang and Manu Ben Johny, explains that large proteins called calcium channels are the gatekeepers that determine when calcium enters cells.

Embedded in cell membranes, these channels open and shut to regulate calcium flow into the cell. When calcium goes into cells, it sets off a cascade of vital activity, but just the right amount of calcium must enter otherwise, problems arise. To achieve this balance, two chemical regulators bind to calcium channels as a brake and acc
'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.org
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Johns Hopkins researchers uncover genes at fault for cystic fibrosis-related intestinal obstruction
2. Johns Hopkins researchers link 2 biological risk factors for schizophrenia
3. The Johns Hopkins Center for Inherited Disease Research receives $101 million
4. 3 Johns Hopkins researchers named AAAS Fellows
5. NREL and Johnson Matthey announce 5-year collaboration on biofuels
6. 3 Johns Hopkins researchers recognized for medical inventions
7. Johns Hopkins And Belgian research center to expand health care applications for silicon nanotech
8. 4 Johns Hopkins researchers named AAAS Fellows
9. Genetic predictors of postpartum depression uncovered by Hopkins researchers
10. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
11. Queens scientists seek vaccine for Pseudomonas infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... deadly disease that exists as five strains, none of ... strains is the Sudan ebolavirus (SUDV). Although not the ... illness, even as recently as 2012. In a new ... , researchers now report a possible therapy that could ... Dye, Sachdev Sidhu, Jonathan Lai and colleagues explain that ...
(Date:8/27/2014)... have largely succeeded in sidelining the use of ... its potential contributions to Americans, health conditions. But ... best way to assuage the nation,s insatiable sweet ... & Engineering News (C&EN), the weekly news ... the article, Stephen Ritter, a senior correspondent at ...
(Date:8/27/2014)... bacterium that can be found in both unprocessed and ... in Denmark have been infected with Listeria ... , The bacterium is notoriously difficult to fight because ... changes in its surroundings, says Associate Professor Birgitte Kallipolitis, ... Department of Biochemistry and Molecular Biology, she has published ...
Breaking Biology News(10 mins):Potential therapy for the Sudan strain of Ebola could help contain some future outbreaks 2Researchers discover why Listeria bacterium is so hard to fight 2Researchers discover why Listeria bacterium is so hard to fight 3
... . The conditioning Works of Sierra Nevada,s ski ... researchers of the University of Granada (Spain) have ... species in order to suggest new mechanisms for vegetable cover ... biodiversity in the National Park of Sierra Nevada . ...
... French . , A novel x-ray technique allowing ... reached before has been developed by a team of researchers ... Results of the research led by Professor Majed Chergui, head ... FEMTO group at PSI appear online December 11 in the ...
... on the environment have reduced populations of wild ... more apparent than in worldwide fisheries, where thanks ... populations of fish are on the brink of ... dire situation, captive breeding, the controlled breeding of ...
Cached Biology News:An essay proves that vegetation could recover in the ski resort of Sierra Nevada 2Molecules in the spotlight 2
(Date:8/27/2014)... -- Rhythm, a biopharmaceutical company developing peptide therapeutics that ... metabolic disorders, announced today that it has filed a ... and Exchange Commission (SEC) relating to the proposed initial ... number of shares to be offered and the price ... Citigroup and Cowen and Company will act ...
(Date:8/27/2014)... The Global and China Trifluoroacetic Acid ... current state of the Trifluoroacetic Acid industry in Global ... of the industry, including definitions, applications and industry chain ... are provided with a focus on history, developments, trends ... the international and Chinese situation is also offered. , ...
(Date:8/27/2014)... “We are honored to be named to this ... of Radiant Sage. “We are offering truly ground-breaking clinical ... market to a different level. We are enabling ... and effectively manage the massive amounts of medical imaging ... read by trained physicians. Being recognized by technology industry ...
(Date:8/27/2014)... , Aug. 27, 2014 Research ... "Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014" ... Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 ... state of the global isotope ratio mass spectrometer industry. ... the industry including definitions, classifications, applications and industry chain ...
Breaking Biology Technology:Rhythm Files Registration Statement for Proposed Initial Public Offering 2Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2
... Web-software services provider Zywave Inc. recently announced it ... being constructed in the Milwaukee County Research Park . ... real estate development circles, but the news is more than ... playing out, and an example of how a powerful business ...
... - Public officials on both sides of the ... during Republican and Democratic administrations, but judging by the ... the Joint Committee on Finance , there is ... ,That division was illustrated this week when Joint Finance, ...
... Wis. - Small Tree Communications , a ... million defense contract for continued development of communications technology. ... appropriations bill, was awarded through a competitive award process. ... communications capabilities for the United States Army . ...
Cached Biology Technology:Corporate venturing can nurture software success 2Corporate venturing can nurture software success 3Corporate venturing can nurture software success 4Corporate venturing can nurture software success 5Corporate venturing can nurture software success 6GOP, Dems split over funding of state technology projects 2GOP, Dems split over funding of state technology projects 3GOP, Dems split over funding of state technology projects 4
... kit, 110 to 220 V, enables ... doubles flow rates and valve capacity ... kit includes the Maximizer base unit, ... tubing kit, system cable 30, and ...
... pen has been designed to provide a thin film-like ... on a slide. This barrier creates the proper ... target area on the slide. PAP Pen contains ... acetone. It can be removed, if desired, by ...
... any scanner into a gel densitometer. Although ... the basic operation simply consists of converting ... into pixel density / intensity values through ... Turn your scanner into a high speed ...
Anti-Conjugated Quinaldic Acid...
Biology Products: