Navigation Links
Johns Hopkins scientists expose cancer cells' universal 'dark matter'
Date:6/26/2011

parison, cells from colon tumors comprising those same huge blocks had no such stability and were much more variable in terms of methylation levels.

Feinberg says the findings could mean that current efforts to simply identify methylation markers as signals of cancer or targets of cancer therapy may be misleading or worse, won't do the job at all. An alternative would be a new method that detects epigenetic chaos universally in any cancer epigenome.

The team designed a custom test to compare about 20 noncancerous tissue samples to 20 samples from each of a variety of tumors as they investigated thousands of methylation sites for colon, breast, lung, kidney and thyroid cancers. They found that, here again, methylation was well-regulated in the normal tissues, almost always occurring within a limited range of variability. However, in the very same specific places of the epigenome characterized by chaos in colon cancer cells, all the other cancerous tissues examined by the team showed distinctly variable and "chaotic" levels of methylation variation.

"Maybe the big lesson learned from our observation of this universal chaos is that we may need to think not so much about just killing cancer cells, but also about ways of helping cancer cells figure out how to be what they're supposed to be, and re-educate them so they can stay truer to their normal identities," Feinberg says.

From the cancer cells' "perspective," Feinberg says, the chaos is helpful, endowing tumors with the ability to turn genes on and off in an uncontrolled way, and making cancer cells adaptable enough to live in all different kinds of environments, spread and thrive in foreign tissue.

"The regions of epigenetic chaos where methylation appears wildly variable in at least five different common cancers are -- not so coincidentally -- the very same as those that during normal development are important in controlling cell differentiation, or what particular ce
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
2. Johns Hopkins scientists pull proteins tail to curtail cancer
3. Case Western Reserve University works with Johnson & Johnson Services Inc. on research grant
4. Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant awarded to Johns Hopkins Early Career investigator
5. Johns Hopkins scientists discover a controller of brain circuitry
6. JDRF announces diabetes research program with Johnson & Johnson
7. Johnson & Johnson award goes to research of the cause of brain cell damage in Parkinsons
8. American Society for Microbiology honors Ryan Johnson
9. UNCs Dr. Sean McLean receives Robert Wood Johnson Foundation award
10. Johns Hopkins researchers reshape basic understanding of cell division
11. Encyclopedia of Life names Dr. Rebecca Johnson a 2011 Rubenstein Fellow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... MOUNTAIN VIEW, Calif. , Nov. 20, 2014 /PRNewswire/ ... for higher driver efficiency are piloting the North American ... the number of accidents growing, gesture recognition systems that ... will make a mark in the industry. ... of the Automotive Gesture Recognition Market in ...
(Date:11/18/2014)... Md. , Nov. 17, 2014 The Parenteral ... and U.S. regulatory agencies will speak and at least seven ... Metrics Conference at the Omni Shoreham Hotel in ... pleased once again to have significant support from the regulatory ... Europe in our effort to help ...
(Date:11/10/2014)... U.S. store shelves in early 2010, and people have ... packets can be tossed into a washing machine without ... The convenience, though, has come with risks for young ... Children,s Hospital found that from 2012 through 2013, U.S. ... than 6 years of age swallowing, inhaling, or otherwise ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Study finds laundry detergent pods, serious poisoning risk for children 2
... and athletes choose to wear the color red when they ... Science , a journal of the Association for Psychological Science, ... levels. The new study, conducted by psychological scientist Daniel ... males who chose red as their color in a competitive ...
... at sites outside the bone marrow in the ... in Munich now show that a specific type of ... cells. Balanced hematopoiesis is essential for the function ... place mainly in the liver and the spleen. Later ...
... the gym. But doctors use the human pulse as a ... professor of chemical engineering at Stanford, has developed a heart ... a postage stamp. The flexible skin-like monitor, worn under an ... doctors detect stiff arteries and cardiovascular problems. The devices ...
Cached Biology News:High-testosterone competitors more likely to choose red 2Herpes infections: Natural killer cells activate hematopoiesis 2Stanford engineers monitor heart health using paper-thin flexible 'skin' 2Stanford engineers monitor heart health using paper-thin flexible 'skin' 3
(Date:11/21/2014)... , Nov. 20, 2014 /CNW/ - Aequus ... to announce that it has closed a brokered ... warrants for approximately C$3.7 million.  Cormark Securities Inc. ... in the Brokered Offering for a syndicate of ... PI Financial Corp. (collectively the "Agents"). Concurrently with ...
(Date:11/18/2014)... Calif. , Nov. 18, 2014 Cord ... platinum sponsor of the 10th Annual World Stem Cell Summit, ... medicine stakeholders. The 2014 World Stem Cell Summit will be ... San Antonio, Texas . The ... and development of lifesaving cures and therapies, convening the most ...
(Date:11/18/2014)... pH measurement and control is vital in a ... food and beverage industries. But what exactly is pH, ... sensors work? METTLER TOLEDO has produced a guide to ... these questions and more. , METTLER TOLEDO provides a ... The actual sensor, the pH electrode, is therefore the ...
(Date:11/18/2014)... 18, 2014 American Process Inc. ... formed a partnership with researchers at Georgia Institute ... Technology, and the USDA’s Forest Products Laboratory to ... nanocellulose. Nanocellulose is a rapidly emerging high performance ... project is to replace heavy steel structures within ...
Breaking Biology Technology:Aequus Pharmaceuticals closes $4.2 million private placement financing 2Aequus Pharmaceuticals closes $4.2 million private placement financing 3Cord Blood Registry Sponsors 2014 World Stem Cell Summit 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 3pH Guide from METTLER TOLEDO Explains Measurement, Theory and Practice of pH Applications 2American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 2American Process Inc. Announces Partnership to Develop Ultra-Strong, Lightweight Automotive Components Using Nanotechnology from Nature 3
... ... launching of PrescriberPRO@Home. This Database will allow marketers to send targeted offers to Physicians, ... , ... 23, 2010 -- Healthcare Data Solutions (HDS) has recently expanded its healthcare ...
... Inc. (Nasdaq: ITMN ) announced today that it will release first ... 4:00 p.m. Eastern time .  A live conference call and webcast ... that same day. , , ... access the live teleconference, dial 888-799-0528 (U.S.) or 973-200-3372 (international), conference ID# ...
... ... to Qualify for Free Oragene®•DNA Collection Kits for Classroom Use , ... Ottawa, ON (PRWEB) April 22, 2010 ... stabilization and preparation, today announced it is marking DNA Day 2010 by introducing a ...
Cached Biology Technology:Healthcare Data Solutions Announces Latest Database, PrescriberPRO@Home. 2Healthcare Data Solutions Announces Latest Database, PrescriberPRO@Home. 3InterMune to Release First Quarter Financial Results on April 29 2DNA Genotek Marks DNA Day 2010 with a Focus on Supporting Science Education 2DNA Genotek Marks DNA Day 2010 with a Focus on Supporting Science Education 3
... phase reagent for Virus ... & unique water insoluble ... detergents and chaotropes; Engineered ... non-envelop viruses while preserving ...
Golgi Sampler Kit 10g each...
Caveolin Sampler Kit 10g each...
Monoclonal Antibody toSynapsin I a and I b Neurofilament associated protein from mouse brain extracts (4)....
Biology Products: