Navigation Links
Johns Hopkins scientists discover a controller of brain circuitry
Date:12/28/2009

e some involvement with dendrites.

Kolodkin, a professor in the neuroscience department at Johns Hopkins and a Howard Hughes Medical Institute investigator, discovered and cloned the first semaphorin gene in the grasshopper when he was a postdoctoral fellow. Over the past 15 years, numerous animal models, including strains of genetically engineered mice, have been created to study this family of molecules.

Using two lines of mice one missing semaphorin and another missing neuropilin, its receptor postdoctoral fellow Tracy Tran used a classic staining method called the Golgi technique to look at the anatomy of nerve cells from mouse brains. (The Golgi technique involves soaking nerve tissue in silver chromate to make cells' inner structures visible under the light microscope; it allowed neuroanatomists in 1891 to determine that the nervous system is interconnected by discrete cells called neurons.)

Tran saw unusually pronounced "spines" sprouting willy-nilly in peculiar places and in greater numbers on the dendrites in the neurons of semaphorin-lacking and neuropilin-lacking mice compared to the normal wild-type animals. It's at the tips of these specialized spines that a lot of synapses occur and neuron-to-neuron communication happens, so Tran suspected there might be more synapses and more electrical activity in the neurons of the mutant mice.

The researchers tested this hypothesis by examining even thinner brain slices under an electron microscope.

The spines of both semaphorin-lacking and neuropilin-lacking mice were dramatically enlarged, compared to those of the smaller, spherical-looking spines in the wild-type mice. In wild types, Tran generally noted a single site of connection per spine. In the mutants, the site of connection between two neurons was often split.

Next, the team recorded the electrical output of mutant and wild-type neurons and found that the mutants, with more spines and larg
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Grant to fund answers about St. Johns River
2. Johns Hopkins scientists discover what drives the development of a fatal form of malaria
3. Johnson & Johnson honors 2008 recipients of the Dr. Paul Janssen Award for Biomedical Research
4. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
5. Johns Hopkins scientists pull proteins tail to curtail cancer
6. JDRF announces diabetes research program with Johnson & Johnson
7. Johnson & Johnson award goes to research of the cause of brain cell damage in Parkinsons
8. Vaginal reconstruction not needed for most inter-sex females, Hopkins study shows
9. Worth a thousand words: Hopkins researchers paint picture of cancer-promoting culprit
10. Hopkins researchers piece together gene network linked to schizophrenia
11. Hopkins scientists ID 10 genes associated with a risk factor for sudden cardiac death
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Johns Hopkins scientists discover a controller of brain circuitry
(Date:7/31/2015)... de 2015 La 10 th International Conference ... de BGI del 22 al 25 de octubre de 2015 en ... año, la conferencia celebra su décimo aniversario. Desde su inauguración ... de las reuniones anuales más influyentes del mundo en el ... dinámicas, entusiastas y mejores a nivel científico. ...
(Date:7/31/2015)... 2015 The 10 th International Conference on ... October 22-25, 2015, in Shenzhen , ... celebrating its 10 th anniversary this year. Since its inauguration ... influential annual meetings in the ,omics, fields, and is one ... ICG-10 focuses on recent breakthroughs and advances in ...
(Date:7/27/2015)... 27, 2015   Zynx Health ™, the ... improvement solutions, today announced that its ZynxCarebook ... on Android smartphones and tablets. With this expansion, ... can use ZynxCarebook to securely exchange messages and ... care transitions to other care settings, and improve ...
Breaking Biology News(10 mins):La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3The 10th International Conference on Genomics (ICG-10) to Open in October 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3
... New evidence reported in the August issue of Cell Stem ... on how the HIV/AIDS virus leads to learning and memory ... on the surface of the virus not only kills some ... also prevents the birth of new brain cells by crippling ...
... two proteins that bind to messenger RNA, a molecule ... into proteins, triggers the appearance of fragile X-associated tremor/ataxia ... that causes fragile X syndrome in children, said researchers ... University School of Medicine in a report that appears ...
... Aug. 15, 2007 A mysterious epidemic of thyroid ... be linked to exposure to dust shed from flame ... scientists are reporting in a study scheduled for publication ... Technology, a semi-monthly journal from the American Chemical Society, ...
Cached Biology News:HIV is a 'double hit' to the brain 2Researchers identify proteins involved in new neurodegenerative syndrome 2Study links cat disease to flame retardants in furniture and to pet food 2Study links cat disease to flame retardants in furniture and to pet food 3
(Date:7/30/2015)... globe, ISN improves the efficiency and effectiveness of contractor management systems. ISN,s online contractor ... in over 80 countries. ... ... Over 60,000 Worldwide Customers In More Than 80 Countries ... Dallas, TX , ISN has additional offices in Calgary , ...
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... ... for advanced fluid applications and designed for continuous operation up to 1500 bar. ... sterilization-in-place, ensuring safety, efficiency, and preventing toxic contamination. , The Pony™ NS2006L homogenizer ...
(Date:7/29/2015)... 2015: +14% CER / 20% of sales) led the regional performance in the ... as well as solid contributions from Korea, India and ... Middle East / Africa (Q2 2015: +3% ... Turkey and the United Kingdom . ... U.S. HPV sales, on demand across all customer classes. The top seven emerging ...
(Date:7/29/2015)... Research and Markets ... the "Global Biosimilars Market, 2015 - 2025" ... Global Biosimilars Market, 2015 - 2025, report provides ... market. With the blockbuster biologics losing patent protection ... are being viewed as viable substitutes to the ...
Breaking Biology Technology:ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2QIAGEN Reports Results for Second Quarter and First Half of 2015 2QIAGEN Reports Results for Second Quarter and First Half of 2015 3QIAGEN Reports Results for Second Quarter and First Half of 2015 4QIAGEN Reports Results for Second Quarter and First Half of 2015 5QIAGEN Reports Results for Second Quarter and First Half of 2015 6QIAGEN Reports Results for Second Quarter and First Half of 2015 7QIAGEN Reports Results for Second Quarter and First Half of 2015 8QIAGEN Reports Results for Second Quarter and First Half of 2015 9QIAGEN Reports Results for Second Quarter and First Half of 2015 10Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 3
... pure proteinTHOUSAND OAKS, Calif., Feb. 24 Bone Biologics, ... organization, Aragen Bioscience, has completed development of a recombinant ... recombinant protein. Bone Biologics has been developing the protein ... ten years of research in the lab performed by ...
... Genencor, a division of Danisco A/S, launched Accellerase(R) ... enzyme product. Genencor introduced the product at the ... in San Antonio, TX.Accellerase(R) 1500 is another significant ... made from cellulosic feedstocks, such as agricultural residues ...
... Ohio, Feb. 24 EyeScience Labs has launched ... comprehensive information and education on age-related macular degeneration (AMD) ... progressive, hereditary eye disease that is the leading cause ... the site, visitors can learn about basic eye anatomy, ...
Cached Biology Technology:Bone Biologics Announces UCB-1 (NELL-1) Bone Growth Protein Production Process With Aragen Biosciences 2Genencor Launches Accellerase(R) 1500, Next Step Toward Scale-Up of Cellulosic Ethanol 2EyeScience Launches Comprehensive Online Resource Devoted to Age-Related Macular Degeneration Education and Prevention 2
in vitro Translation, Accessory Products...
... RiboGreen RNA Quantitation Kit is one ... for the quantitation of RNA in ... 1000-fold more sensitive than absorbance measurements. ... be detected with fluorescence microplate readers ...
Donor Horse Serum US Origin...
... 53 new primer sets added in Dec ... than 3 hours , Detection from ... , Specific primers available for hundreds ... either real-time or end-point RT-PCR , ...
Biology Products: