Navigation Links
Johns Hopkins scientists discover a controller of brain circuitry
Date:12/28/2009

By combining a research technique that dates back 136 years with modern molecular genetics, a Johns Hopkins neuroscientist has been able to see how a mammal's brain shrewdly revisits and reuses the same molecular cues to control the complex design of its circuits.

Details of the observation in lab mice, published Dec. 24 in Nature, reveal that semaphorin, a protein found in the developing nervous system that guides filament-like processes, called axons, from nerve cells to their appropriate targets during embryonic life, apparently assumes an entirely different role later on, once axons reach their targets. In postnatal development and adulthood, semaphorins appear to be regulating the creation of synapses those connections that chemically link nerve cells.

"With this discovery we're able to understand how semaphorins regulate the number of synapses and their distribution in the part of the brain involved in conscious thought," says David Ginty, Ph.D., a professor in the neuroscience department at the Johns Hopkins University School of Medicine and a Howard Hughes Medical Institute investigator. "It's a major step forward, we believe, in our understanding of the assembly of neural circuits that underlie behavior."

Because the brain's activity is determined by how and where these connections form, Ginty says that semaphorin's newly defined role could have an impact on how scientists think about the early origins of autism, schizophrenia, epilepsy and other neurological disorders.

The discovery came as a surprise finding in studies by the Johns Hopkins team to figure out how nerve cells develop axons, which project information from the cells, as well as dendrites, which essentially bring information in. Because earlier work from the Johns Hopkins labs of Ginty and Alex Kolodkin, Ph.D., showed that semaphorins affect axon trajectory and growth, they suspected that perhaps these guidance molecules might hav
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Grant to fund answers about St. Johns River
2. Johns Hopkins scientists discover what drives the development of a fatal form of malaria
3. Johnson & Johnson honors 2008 recipients of the Dr. Paul Janssen Award for Biomedical Research
4. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
5. Johns Hopkins scientists pull proteins tail to curtail cancer
6. JDRF announces diabetes research program with Johnson & Johnson
7. Johnson & Johnson award goes to research of the cause of brain cell damage in Parkinsons
8. Vaginal reconstruction not needed for most inter-sex females, Hopkins study shows
9. Worth a thousand words: Hopkins researchers paint picture of cancer-promoting culprit
10. Hopkins researchers piece together gene network linked to schizophrenia
11. Hopkins scientists ID 10 genes associated with a risk factor for sudden cardiac death
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Johns Hopkins scientists discover a controller of brain circuitry
(Date:4/15/2014)... research published in the March/April 2014 issue of ... shows whey protein, either as a supplement combined ... or weight-maintenance diet, may provide men and women benefits ... 14 randomized controlled trials with a total of 626 ... that used whey protein to replace calories in the ...
(Date:4/14/2014)... Rican climate over the past three decades have caused ... territory,s national animal. UCLA biologists have found that not ... call has also become shorter and higher pitched. ... of integrative biology and physiology and of ecology and ... the study examined 170 male coqui frogs ( Eleutherodactylus ...
(Date:4/14/2014)... the International Space Station inside the Dragon capsule ... in-orbit food production capabilities in more ways than ... for granted, fresh food. , NASA,s Veg-01 experiment ... and performance of a new expandable plant growth ... investigation will focus on the growth and development ...
Breaking Biology News(10 mins):New meta-analysis builds on the power of whey protein for improved body composition 2New meta-analysis builds on the power of whey protein for improved body composition 3Climate change a likely culprit in coqui frog's altered calls, say UCLA biologists 2Veggie will expand fresh food production on space station 2
... -- Dangerous disease often spreads faster than it takes ... researchers at Kansas State University have developed a test ... Sanjeev Narayanan, assistant professor, and Greg Peterson, research ... pathobiology, use a device called a DNA spotted microarray ...
... Ackermann and Wolf-Dietrich Hardt, in collaboration with Michael Doebeli ... have been able to describe how random molecular processes ... a self-destructive act to generate a greater common good, ... Survival strategy The biologists investigated this ...
... relapse after renewed drug administration are typical behavioral patterns ... the brain,s reward center are directly responsible for this. ... the Institute of Mental Health (ZI) in Mannheim, the ... University of Geneva, Switzerland, in the latest issue of ...
Cached Biology News:Rapid test for pathogens developed by K-State researchers 2ETH Zurich study on salmonella self-destruction 2ETH Zurich study on salmonella self-destruction 3Cocaine: How addiction develops 2
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... Stem cell-enriched autologous fat enables sustainable breast augmentation ... the media: For years a French company has been ... cause cancer. More than 100,000 women worldwide must now ... or carrying a "time bomb" in their bodies. Stem ...
... Biotherapeutics (OTC.BB: NWBO) (NW Bio) today announced that it will ... the Windsor Room of the Sir Francis Drake Hotel as ... emerging biotech companies held over 3 days this week in ... attendees are expected to be listening to presentations by up ...
... SEATTLE, Jan. 10, 2012  Omeros Corporation (NASDAQ: OMER ... selectively with each of GPR25, GPR32, GPR80, GPR135 and MAS1, ... unlocked by Omeros to 23, representing 30 percent of the ... unlocked by Omeros for drug development equals half of the ...
Cached Biology Technology:Silicone Scandal: Stem Cell Breast Augmentation a Safe Alternative 2NW Bio to Present Today at the OneMedForum SF 2012 Conference 2NW Bio to Present Today at the OneMedForum SF 2012 Conference 3Omeros Announces it has Unlocked 30 Percent of Class A Orphan GPCRs 2Omeros Announces it has Unlocked 30 Percent of Class A Orphan GPCRs 3Omeros Announces it has Unlocked 30 Percent of Class A Orphan GPCRs 4Omeros Announces it has Unlocked 30 Percent of Class A Orphan GPCRs 5
Anti-ACTH Immunogen: Porcine ACTH conjugated to BSA. Available Date: 38566...
Goat polyclonal to BACE1 ( Abpromise for all tested applications). entrezGeneID: 23621 SwissProtID: P56817...
... Immunogen: Peptide ... encompassing the human, mouse, and ... Accession Number: NM_000314 ... Routinely evaluated by immunoblot. ...
Mouse monoclonal [MN-8C4] to zona radiata ( Abpromise for all tested applications). Antigen: Purified eggshell proteins (zona radiata proteins and small amounts of zona pellucida proteins) from ...
Biology Products: