Navigation Links
Johns Hopkins scientists discover a controller of brain circuitry
Date:12/28/2009

By combining a research technique that dates back 136 years with modern molecular genetics, a Johns Hopkins neuroscientist has been able to see how a mammal's brain shrewdly revisits and reuses the same molecular cues to control the complex design of its circuits.

Details of the observation in lab mice, published Dec. 24 in Nature, reveal that semaphorin, a protein found in the developing nervous system that guides filament-like processes, called axons, from nerve cells to their appropriate targets during embryonic life, apparently assumes an entirely different role later on, once axons reach their targets. In postnatal development and adulthood, semaphorins appear to be regulating the creation of synapses those connections that chemically link nerve cells.

"With this discovery we're able to understand how semaphorins regulate the number of synapses and their distribution in the part of the brain involved in conscious thought," says David Ginty, Ph.D., a professor in the neuroscience department at the Johns Hopkins University School of Medicine and a Howard Hughes Medical Institute investigator. "It's a major step forward, we believe, in our understanding of the assembly of neural circuits that underlie behavior."

Because the brain's activity is determined by how and where these connections form, Ginty says that semaphorin's newly defined role could have an impact on how scientists think about the early origins of autism, schizophrenia, epilepsy and other neurological disorders.

The discovery came as a surprise finding in studies by the Johns Hopkins team to figure out how nerve cells develop axons, which project information from the cells, as well as dendrites, which essentially bring information in. Because earlier work from the Johns Hopkins labs of Ginty and Alex Kolodkin, Ph.D., showed that semaphorins affect axon trajectory and growth, they suspected that perhaps these guidance molecules might hav
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Grant to fund answers about St. Johns River
2. Johns Hopkins scientists discover what drives the development of a fatal form of malaria
3. Johnson & Johnson honors 2008 recipients of the Dr. Paul Janssen Award for Biomedical Research
4. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
5. Johns Hopkins scientists pull proteins tail to curtail cancer
6. JDRF announces diabetes research program with Johnson & Johnson
7. Johnson & Johnson award goes to research of the cause of brain cell damage in Parkinsons
8. Vaginal reconstruction not needed for most inter-sex females, Hopkins study shows
9. Worth a thousand words: Hopkins researchers paint picture of cancer-promoting culprit
10. Hopkins researchers piece together gene network linked to schizophrenia
11. Hopkins scientists ID 10 genes associated with a risk factor for sudden cardiac death
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Johns Hopkins scientists discover a controller of brain circuitry
(Date:10/15/2014)... The German Gauß-Allianz has admitted Johannes Gutenberg University ... the Rhineland-Palatinate science hub continues to maintain a ... computing. , "The acceptance of Johannes Gutenberg ... Gauß-Allianz is a milestone in the national and ... support. The state of Rhineland-Palatinate can be proud ...
(Date:10/15/2014)... , Oct. 15, 2014   Neurotechnology ... today announced the availability of the VeriLook ... Surveillance 3.0 provides real-time biometric face identification using ... digital surveillance cameras. The new version not only ... differentiates people from objects while they are moving ...
(Date:10/14/2014)... planet,s leading questions is how to produce enough food ... The Food and Agriculture Organization of the United Nations ... next 40 years to feed a growing global population, ... rise in food production. Plants—grains, cereals, fruits, vegetables, ... Current research must tap into our knowledge of ...
Breaking Biology News(10 mins):Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
... deserts as inhospitable places devoid of life, but numerous ... where they often compete for limited resources. In desert ... plants to adopt different strategies to compete with their ... availability is often stochasticsome years and localities receive lots ...
... temperatures will rise at least 4C by 2100 and potentially ... not reduced according to new research published in Nature ... dioxide than most previous estimates. , The research also appears ... the role of cloud formation and whether this will have ...
... years, but scientists in Arizona and Europe have teased out ... in the honeybee. The first genetic mechanism for ... monk named Johann Dzierson, according to the study,s co-author and ... trying to understand how males and females were produced in ...
Cached Biology News:Competition in a rough neighborhood: Plant success in a desert environment 2Competition in a rough neighborhood: Plant success in a desert environment 3Cloud mystery solved: Global temperatures to rise at least 4°C by 2100 2Molecular evolution of genetic sex-determination switch in honeybees 2Molecular evolution of genetic sex-determination switch in honeybees 3
(Date:10/19/2014)... The Latin American hardware encryption display market ... with analysis and forecast of revenue. This market was ... to reach $2,366.8 million by 2018, at a CAGR ... the TOC of the Latin American hardware encryption market ... provided. It also provides a glimpse of the segmentation ...
(Date:10/19/2014)... Asia-Pacific Speech Analytics market report defines and segments the ... of revenue. This market is estimated to grow from ... at a Compound Annual Growth Rate (CAGR) of 23.9% ... of the Asia-Pacific Speech Analytics market report to get ... provides a glimpse of the segmentation in the market, ...
(Date:10/18/2014)... The “Human Insulin Market- by ... Premixed), Modern Human Insulin (Rapid Acting, Long Acting, ... Tresiba, Others) - Forecast to 2018” provides a ... opportunities, current market trends, and strategies impacting the ... and forecasts of the revenue and share analysis. ...
(Date:10/18/2014)... The Asia-Pacific Liquid Crystal on Silicon ... market in Asia-Pacific with analysis and forecast of revenue. ... and is expected to reach $380.0 million by 2018, ... , Browse through the TOC of the Asia-Pacific LCoS ... in-depth analysis provided. This also provides a glimpse of ...
Breaking Biology Technology:The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 5The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Liquid Crystal on Silicon (LCoS) display market is expected to reach $380.0 million by 2018 - New Report by MicroMarket Monitor 3
... Waukesha, Wis. - RedPrairie Corp. ... a new suite of supply-chain solutions during a recent ... user conference and logistics industry summit, RedPrairie unveiled its ... end-to-end product that addresses the consumer-driven supply chain challenges ...
... - Technology executive and author Tom Kelley calls them ... them bozos. Whatever label or moniker one attaches to ... act as speed bumps or roadblocks to innovation, and ... ,So powerful, in fact, that they threaten to stifle ...
... Waukesha, Wis. - Two healthcare giants, GE ... enter into a collaboration agreement to develop a ... heart rhythm disease. , ,Under terms of the ... with fully integrated intracardiac echocardiography (ICE) imaging capabilities ...
Cached Biology Technology:Manufacturers face challenges of innovation 2Manufacturers face challenges of innovation 3GE, St. Jude to collaborate on visualization technology 2