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Johns Hopkins researchers reshape basic understanding of cell division
Date:11/5/2010

appens when myosin II muscle-moving machinery is disturbed, suggesting that 14-3-3 plays a critical role in cell shape dynamics and cell division.

The amoeba has only one form of the 14-3-3 protein compared to humans, whose seven forms interact with hundreds of proteins to regulate many cellular processes. Some 14-3-3s in humans are thought to be tumor suppressors because their function is lost in tumor cells; other 14-3-3s in humans are over-productive in certain types of cancers, suggesting that they may be biomarkers for disease progression.

Ironically, division failure may put a cell on the pathway of tumor development because it results in a cell having twice as many parts and chromosomes during the next cell cycle. Such chromosomal instability may put it at risk of losing genetic material such as tumor suppressors.

Tumor cells often have alterations in their mechanical properties, Robinson says, adding that those alterations are thought to contribute to how cells can metastasize, invade and pass through different cell layers to migrate to new locations in the body.

Says Robinson: "Having studied myosin II for 13 years, it still surprised us that 14-3-3 coordinates myosin II in the critical processes of cell shape change and division."


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Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

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