Navigation Links
Johns Hopkins researchers link cell division and oxygen levels
Date:6/10/2011

d, the activity of HIF-1 went down, while reducing the levels of MCMs, led to increased HIF-1 activity. "HIF-1 instructs cells not to divide, since more cells will consume more oxygen, making any shortage of oxygen even worse, while the role of MCMs is to trigger cell division" says Semenza. "So it's not surprising that MCMs would oppose the action of HIF-1."

The team also noticed that there seemed to be less MCM7 present when cells were exposed to low oxygen for 24 hours. To see if this had anything to do with HIF-1, they first turned up HIF-1 levels in cells--by either exposing them to low oxygen or treating them with a drug that boosts HIF-1 production--and found a decrease in the levels of MCM proteins 24 hours later. Separately, they removed HIF-1 from cells, then exposed the cells to low oxygen and found no change in MCM protein levels, allowing the group to conclude that HIF-1 controls MCM proteins as well, so that the MCMs and HIF-1 oppose each other's action. "It's like a tug of war," says Semenza. "When oxygen and nutrients are plentiful, MCMs win, and cells divide. When oxygen is low, HIF-1 wins and cell division is prevented. The mutual antagonism may be critical for tightly controlling cell growth based on oxygen availability."


'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Johns Hopkins scientists reveal nerve cells navigation system
2. Texas researcher Arthur E. Johnson to give prestigious ASBMB-Lipmann Lectureship
3. Johns Hopkins team creates stem cells from schizophrenia patients
4. Johns Hopkins researchers capture jumping genes
5. Encyclopedia of Life names Dr. Rebecca Johnson a 2011 Rubenstein Fellow
6. Johns Hopkins researchers reshape basic understanding of cell division
7. UNCs Dr. Sean McLean receives Robert Wood Johnson Foundation award
8. American Society for Microbiology honors Ryan Johnson
9. Case Western Reserve University works with Johnson & Johnson Services Inc. on research grant
10. Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant awarded to Johns Hopkins Early Career investigator
11. Johns Hopkins scientists discover a controller of brain circuitry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/16/2015)... , March 16, 2015 ... Systems GmbH will present groundbreaking innovations in biometric ... Hanover, Germany .      (Photo: ... latest biometric innovation is well at the forefront: ... generation e-gate made in Germany ...
(Date:3/11/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/3p32qm/access_control ... Control Market by Product, Application & By Geography - ... their offering. , This report predicts that ... billion by 2020, with an estimated CAGR of 10.6%. ... products types such as contact cards & readers, contactless ...
(Date:3/10/2015)... , March 10, 2015  NXT-ID, Inc. (NASDAQ: ... the "Company"), a biometric authentication company focused on ... Wocket™ smart wallet has been named the "Number ... Modern. Rethink Modern ( http://www.rethinkmodern.com/ ) ... for your home and lifestyle that have a unique ...
Breaking Biology News(10 mins):DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4
... climate change will reach a tipping point in less ... health of the planet,s coral reef ecosystems according to ... Released by the Global Coral Reef Monitoring Network and ... partnerships, "Status of Coral Reefs of the World: 2008" ...
... by a Michigan State University chemist could eventually lead ... drugs that are key to treating a number of ... in drug manufacture and research often are made within ... That protein tends to collect into what scientists call ...
... study published in the current issue of CELL ... - fat cells - could become a source for ... , According to the study,s lead researcher, Dr. Yuki ... University School of Medicine, Kawasaki, Japan, adipose-derived stem/stromal cells ...
Cached Biology News:Time running out on coral reefs as climate change becomes increasing threat 2Time running out on coral reefs as climate change becomes increasing threat 3Transplanted fat cells restore function after spinal cord injury 2
(Date:3/27/2015)... 2015  Peter Walter wurde als Gewinner ... seine bahnbrechende Arbeit ausgewählt, die sich damit ... sowie für die Entschlüsselung der Komponenten eines ... nutzen, der mit der Ansammlung von deformierten ... Biochemie an der University of California, San ...
(Date:3/27/2015)... -- WuXi PharmaTech (Cayman) Inc. (NYSE: WX ... platform company serving the global pharmaceutical, biotechnology, and ... New Drug (IND) application for WuXi MedImmune,s novel ... accepted for review by the China Food and ... 2012, MedImmune, the global biologics research and development ...
(Date:3/26/2015)... 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or the ... with certain matters, including the appointment of auditors, its ... 26, 2015 (the "Meeting") was adjourned, as previously disclosed ... 11:00 a.m. ( Toronto time). The ... that previous disclosed. The Meeting will reconvene at the ...
(Date:3/26/2015)... BOSTON , March 26, 2015 /PRNewswire/ ... ), a global clinical research organization ... signed a definitive agreement to acquire all ... India ("QSI"), a leading provider of specialized ... refers to the collection, detection, assessment, monitoring, ...
Breaking Biology Technology:Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 3Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 4Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 3SQI Diagnostics Inc. Announces Adjournment of Meeting 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4
... that a new market research report is available in ... Technologies and Global Markets http://www.reportlinker.com/p0298002/Cancer-Profiling-and-Pathways-Technologies-and-Global-Markets.html ... Cancer Profiling Technologies at about $15 billion in 2009. ... 2010 and $47 billion by 2015, at a compound ...
... BURLINGTON, Mass., Sept. 23 Decision Resources, one ... for pharmaceutical and healthcare issues, finds that growth ... by chronic myelogenous leukemia (CML) therapies (Novartis,s Gleevec ... lymphocytic leukemia (CLL) therapies (Biogen Idec/Roche,s Rituxan and ...
... samples generated during clinical research is rapidly increasing as ... traditional medicine to molecular-based therapeutics. The growing use of ... an increasing emphasis on the value of sample integrity ... collect, store and distribute clinical trial samples. ...
Cached Biology Technology:Reportlinker Adds Cancer Profiling and Pathways: Technologies and Global Markets 2Reportlinker Adds Cancer Profiling and Pathways: Technologies and Global Markets 3Reportlinker Adds Cancer Profiling and Pathways: Technologies and Global Markets 4Reportlinker Adds Cancer Profiling and Pathways: Technologies and Global Markets 5Reportlinker Adds Cancer Profiling and Pathways: Technologies and Global Markets 6Reportlinker Adds Cancer Profiling and Pathways: Technologies and Global Markets 7Reportlinker Adds Cancer Profiling and Pathways: Technologies and Global Markets 8Reportlinker Adds Cancer Profiling and Pathways: Technologies and Global Markets 9Reportlinker Adds Cancer Profiling and Pathways: Technologies and Global Markets 10Reportlinker Adds Cancer Profiling and Pathways: Technologies and Global Markets 11Reportlinker Adds Cancer Profiling and Pathways: Technologies and Global Markets 12Reportlinker Adds Cancer Profiling and Pathways: Technologies and Global Markets 13Reportlinker Adds Cancer Profiling and Pathways: Technologies and Global Markets 14Reportlinker Adds Cancer Profiling and Pathways: Technologies and Global Markets 15Reportlinker Adds Cancer Profiling and Pathways: Technologies and Global Markets 16Reportlinker Adds Cancer Profiling and Pathways: Technologies and Global Markets 17Drug Sales in the Leukemia Market Will Be Driven By Therapies From Novartis, Bristol-Myers Squibb, Biogen Idec, Roche and Cephalon 2BioStorage Technologies Brings Together Industry Leaders for Global Sample Management Benchmarking Symposium 2BioStorage Technologies Brings Together Industry Leaders for Global Sample Management Benchmarking Symposium 3
Request Info...
... The Fujifilm Life Science FLA-7000 excels ... silver-stained, CBB-stained gel documentation. It features four ... R710, and a filter for Imaging Plates) ... offers a customizable choice of four kinds ...
... Labeling Kit generates labeled cDNA for use ... is made via a reverse transcription from ... Unlike other methods, there are no unnatural ... reaction. This unmodified cDNA is then labeled ...
... enables fully automated hybridization of microarrays on ... been designed to offer researchers improved reproducibility, ... perform a wide range of applications. ... 485C; denaturations of up to 99C. The ...
Biology Products: