Navigation Links
Johns Hopkins researchers link cell division and oxygen levels
Date:6/10/2011

Cells grow abundant when oxygen is available, and generally stop when it is scarce. Although this seems straightforward, no direct link ever has been established between the cellular machinery that senses oxygen and that which controls cell division. Now, in the June 10 issue of Molecular Cell, researchers at Johns Hopkins report that the MCM proteins, which promote cell division, also directly control the oxygen-sensing HIF-1 protein.

"It's always been a mystery why a vast excess of MCM proteins is present in cells, but now we have discovered at least one reason," says Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Medicine, director of the vascular program in Hopkins' Institute for Cell Engineering and a member of the McKusick-Nathans Institute of Genetic Medicine. "Our data indicate that MCMs mediate crosstalk between the cell division machinery and proteins that help cells react to changes in their surroundings."

Since discovering HIF-1 in the 1990s, Semenza's team has been studying how it works to sense oxygen levels and turn on genes that help cells survive when oxygen is low. To find proteins that HIF-1 physically interacts with, the team went on a biochemical fishing expedition and, using HIF-1 as bait, pulled out MCM7. MCM7 is a member of a larger group of related proteins that are known to bind to DNA and start its duplication when a cell gets ready to divide. Using a different protein-binding technique, the team then found that HIF-1 also binds to MCM3.

When it senses low oxygen levels, HIF-1 turns on genes that enable cells to adapt, such as genes that stimulate the growth of new blood vessels and genes that alter a cell's metabolism to change how much oxygen it consumes for energy generation. To understand what MCM proteins do to or with HIF-1, the researchers examined how well HIF-1 turns on genes in the presence and absence of MCM3 or 7. They found when the levels of MCM proteins were increase
'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Johns Hopkins scientists reveal nerve cells navigation system
2. Texas researcher Arthur E. Johnson to give prestigious ASBMB-Lipmann Lectureship
3. Johns Hopkins team creates stem cells from schizophrenia patients
4. Johns Hopkins researchers capture jumping genes
5. Encyclopedia of Life names Dr. Rebecca Johnson a 2011 Rubenstein Fellow
6. Johns Hopkins researchers reshape basic understanding of cell division
7. UNCs Dr. Sean McLean receives Robert Wood Johnson Foundation award
8. American Society for Microbiology honors Ryan Johnson
9. Case Western Reserve University works with Johnson & Johnson Services Inc. on research grant
10. Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant awarded to Johns Hopkins Early Career investigator
11. Johns Hopkins scientists discover a controller of brain circuitry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... cycles of carbon and nitrogen comprise all spheres ... environmental systems have caused imbalances and perturbations that ... (GHGs). Increased GHGs result in climate changes which ... oceans and the atmosphere. Understanding these feedback mechanisms ... of environmental science during the past three decades. ...
(Date:9/18/2014)... camouflage: you don,t just blend in, the background shows ... as you might think. Kathryn Feller, from the University ... life stages of many marine species are transparent. However, ... creatures cannot make transparent. Feller explains that the animals ... unit with an opaque pigment to prevent light leaking ...
(Date:9/17/2014)... of the Santa Ana Wildfire Threat Index a ... the powerful, hot, dry Santa Ana wind, which can ... introduced Sept. 17 by the U.S. Forest Service, in ... , The index includes four classification levels ranging from ... fire agencies and other emergency responders, the media and ...
Breaking Biology News(10 mins):Greenhouse gas research enters a new era 2Transparent larvae hide opaque eyes behind reflections 2UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2
... a plant genetics and developmental biology expert at the ... of 15 five-year, $5 million grants for fundamental plant ... the Howard Hughes Medical Institute (HHMI) and the Gordon ... W. Beadle Professor of Biology at Caltech, is an ...
... the Bourns College of Engineering at the University of California, ... EPA to develop a system could cut electricity bills up ... attic to operate a clothes dryer. The students are ... a 30-home zero net energy, urban agriculture focused community planned ...
... RIDGE, Tenn., June 15, 2011 A first of ... Department of Energy,s Oak Ridge National Laboratory is providing ... biofuels. , Lignin, a major component of plant cell ... the production of cellulosic ethanol. The exact shape and ...
Cached Biology News:Caltech scientist awarded $5 million grant for plant research 2Turning hot air into energy savings 2Turning hot air into energy savings 3ORNL neutrons, simulations reveal details of bioenergy barrier 2
(Date:9/18/2014)... HealthTronics, Inc ., a ... products and services, announced that a poster related ... versus external beam radiotherapy (EBRT) is being presented ... Association (MAAUA) Annual Meeting in Baltimore, Maryland September ... Cryosurgery and External Beam Radiation as Treatments for ...
(Date:9/18/2014)... , September 18, 2014 /PRNewswire/ ... Markets ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced ... Materials - Global Strategic Business Report" ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes the ... US$ Million by the following Product ...
(Date:9/18/2014)... , Sept. 18, 2014 Research ... "Global Human Albumin Industry Report 2014" report ... Albumin Industry Report 2014 is a professional and in-depth ... albumin industry. The report provides a basic ... industry chain structure. The human albumin market analysis is ...
(Date:9/18/2014)...  Neogen Corporation (Nasdaq: NEOG ) announced ... with Merck Animal Health to market Neogen,s Igenity ® ... Dairy Heifer Program consists of genomic tests that offer ... of replacement dairy heifers. The genomic tests can be ... an excellent tool in the decision-making process for breeding ...
Breaking Biology Technology:HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Merck Animal Health to market Neogen's dairy genomic program 2
... Inc.,(NYSE: SNN , LSE: SN) Orthopaedic Reconstruction ... instrumentation for use in total,knee replacement surgery. The VISIONAIRE ... x-rays to create custom surgical instrumentation for,use with the ... , By using instruments designed ...
... EAST LONGMEADOW, Mass., Feb. 23 Texcel Medical, ... development and contract manufacturing company, has announced ... CEO.Smith will oversee all functions at Texcel ... by providing the manufacturing infrastructure and expertise they ...
... Affairs Company LLC,(TMAC(R)), the leading provider of outsourced ... expansion of its medical,communications division. , ... demand for clinician-staffed,project-based medical information and medical meeting ... its Medical Communications division to,better meet these needs. ...
Cached Biology Technology:Smith & Nephew Launches VISIONAIRE(TM) Patient Matched Technology for Total Knee Replacement 2Smith & Nephew Launches VISIONAIRE(TM) Patient Matched Technology for Total Knee Replacement 3Texcel Medical Appoints Barry Smith as President, CEO 2The Medical Affairs Company Expands Its Medical Communications Division 2
Rabbit polyclonal to hnRNP-U...
... DNA Ligase catalyzes the formation of a ... termini in nicked duplex DNA molecules or ... a complementary strand at 45 - 65?. ... at much higher temperatures than conventional DNA ...
RABBIT ANTI RHEB (IN) Immunogen: A 15 amino acid peptide located in the central region of human Rheb....
Rabbit polyclonal antibody to Neuromedin U Receptor 1 (GPR66)...
Biology Products: