Navigation Links
Johns Hopkins researchers identify new genetic risk factor for sudden cardiac death
Date:7/12/2011

In a large and comprehensive investigation into the underlying causes of sudden cardiac death (SCD) a surreptitious killer of hundreds of thousands annually in the United States researchers have discovered a variation in the genome's DNA sequence that is linked to a significant increase in a person's risk of SCD.

The new finding flags a DNA sequence called the BAZ2B locus, a region along the genome containing three genes previously unknown to play any role in cardiac biology, according to a report published online June 30 in PLoS Genetics. Understanding how genetic variation in this region plays a role in the risk of SCD could eventually help those at risk take steps to prevent it, the researchers say, although they emphasize that a great deal of follow-up work is required.

"Our analysis suggests that if you have one copy of this variant, your increased risk is double that of someone who doesn't," says Dan Arking, Ph.D., lead author of the study and an associate professor in the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine. "If you have two copies having inherited one from each parent you have almost a fourfold increased risk of SCD."

Statistically significant though it is, this variant alone doesn't give scientists the information they need to proceed with a clinically useful test or therapy, Arking says. Scientists first need to figure out which of the three genes in the region is the key player, and determine how that gene's function is compromised likely by using model organisms to investigate their heart-related biological activity.

To identify the variant, a consortium of researchers first combined five separate genome wide association studies to survey each of the 3 billion base pairs in the DNA sequences of 1,283 individuals of European ancestry who experienced SCD, and more than 20,000 individuals without SCD. They followed up suggestive findings in an addi
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Johns Hopkins researchers awarded $32 million
2. Johns Hopkins scientists expose cancer cells universal dark matter
3. Johns Hopkins researchers link cell division and oxygen levels
4. Johns Hopkins scientists reveal nerve cells navigation system
5. Texas researcher Arthur E. Johnson to give prestigious ASBMB-Lipmann Lectureship
6. Johns Hopkins team creates stem cells from schizophrenia patients
7. Johns Hopkins researchers capture jumping genes
8. Encyclopedia of Life names Dr. Rebecca Johnson a 2011 Rubenstein Fellow
9. Johns Hopkins researchers reshape basic understanding of cell division
10. UNCs Dr. Sean McLean receives Robert Wood Johnson Foundation award
11. American Society for Microbiology honors Ryan Johnson
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... German Gauß-Allianz has admitted Johannes Gutenberg University Mainz ... Rhineland-Palatinate science hub continues to maintain a significant ... , "The acceptance of Johannes Gutenberg University ... is a milestone in the national and international ... The state of Rhineland-Palatinate can be proud that ...
(Date:10/15/2014)... SHELTON, Conn. , Oct. 15, 2014 NXT-ID, Inc. ... a biometric authentication company focused on the growing mobile commerce market ... NASDAQ MarketSite in Times Square on Monday October 13 th . ... with CTO David Tunnel and angel investor Mr. ... Gino Pereira , CEO of NXT-ID thanked his investors and employees ...
(Date:10/14/2014)... discriminating thieves, prostate cancer tumors scavenge and hoard copper ... such avarice may be a fatal weakness. , ... kill prostate cancer cells by delivering a trove of ... diseased cells brimming with the mineral, leaving non-cancer cells ... already commercially available for other uses, could soon be ...
Breaking Biology News(10 mins):Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Prostate cancer's penchant for copper may be a fatal flaw 2
... exposure, serving size and parental behavior are the key drivers ... discussion at the 2013 Institute of Food Technologists (IFT) Annual ... standing-room only crowd of more than 200 conference attendees heard ... what their eating behaviors are and how the industry and ...
... approved to treat multiple sclerosis may also hold promise for ... that often leads to heart failure, researchers at the University ... findings are published in the July 16 issue of ... thickening of the heart muscle that shrinks the interior ...
... have taken part in an international study which has revealed ... in one of the most hostile environments on earth. ... Tibetan plateau, the largest high-altitude land mass in the world. ... genome which reveal how it copes with the extreme living ...
Cached Biology News:Taste rules for kids and healthy food choices 2MS drug shows promise for preventing heart failure 2Genetic secrets of the world's toughest little bird 2Genetic secrets of the world's toughest little bird 3
(Date:10/22/2014)... 2014 Involution Studios , a ... a new infographic, Understanding Ebola . The ... designed, easy to follow informative tool for anyone wanting ... symptoms and prevention. , "As the news has spread ... Ebola outbreak represents not only a healthcare crisis with ...
(Date:10/22/2014)... October 22, 2014 Physicians Choice ... cardiovascular pharmacogenetics menu, which enables healthcare providers to ... With PCLS’s evidence-based results, healthcare providers are better ... their therapy, while minimizing risks for adverse drug ... according to the FDA [1] more than 2.2 ...
(Date:10/22/2014)... 22, 2014 Nuvilex, Inc. (OTCQB: NVLX) – ... people worldwide are living with diabetes, with  that number ... The global market for diabetes treatments is approximately $500 ... worldwide died from pancreatic cancer.  Pancreatic cancer is the ... in the United States , and ...
(Date:10/20/2014)... , Oct. 20, 2014 Mapp ... experimental ZMapp™ antibody therapeutic to fight the Ebola ... difficult and time-consuming the production of pharmaceuticals can ... research publisher said that while some may be ... this compound, those with industry knowledge are well ...
Breaking Biology Technology:Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3
... Paris: FR0005175080) announces promising preliminary data from,the Phase ... an adjunct to first line chemotherapy in patients ... on-going trial is a randomized, open label and ... in combination with cisplatin and,gemcitabine compared to the ...
... BRIDGEWATER, New Jersey and BIRMINGHAM, Alabama,Jan. 10 ... a,leading international scientific and regulatory consulting firm with,specialized ... Food &,Nutrition, Chemicals and Agriculture, Biotech & Consumer ... the new name for their,Pharmaceutical & Healthcare Division., ...
... Essilor,of America, Essilor International,s US subsidiary, has strengthened ... the acquisition,of Interstate Optical Co., one of the ... Mansfield, Ohio and,Indianapolis, Indiana serve eye care professionals ... US$26 million and 210 employees., Present for ...
Cached Biology Technology:Transgene's Therapeutic Vaccine TG4010 Shows Promising Preliminary Phase IIb Data in Advanced Non-Small Cell Lung Cancer 2Transgene's Therapeutic Vaccine TG4010 Shows Promising Preliminary Phase IIb Data in Advanced Non-Small Cell Lung Cancer 3Cantox Announces the Launch of Ashuren Health Sciences Pharmaceutical Division 2
...
Mouse anti-JNK (PT183/185) Class: Antibody Product Group: Signalling molecules and phospho-specific Antibody...
Acetyl CoA Carboxylase Antibody...
mu Opioid Receptor splice variant Immunogen: Synthetic peptide corresponding to residues K S C M D R G M R N L L P D D G P R Q E of Mu Opioid Receptor. Storage: -20 C, Avoid Freeze/Thaw Cycle...
Biology Products: