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John Theurer Cancer Center researchers shared 14 leading edge studies at recent ASCO meeting
Date:7/18/2011

erent response categories.

Clofarabine plus cytarabine compared to cytarabine alone in older patients with relapsed or refractory (R/R) acute myelogenous leukemia (AML): Results from the phase III CLASSIC 1 trial.

Dr. Goldberg and researchers from multiple cancer centers reported the results of the first phase III, prospective, randomized, blinded trial to evaluate the efficacy and safety of clofarabine (CLO) in combination with ara-C compared to ara-C alone in older adult pts (≥55 yrs) with refractory acute myelogenous leukemia (AML). 320 patients were enrolled. Median overall survival was 6.6 months and 6.4 months in the CLO+ara-C and ara-C alone study arms, respectively. The authors conclude that the study demonstrates that CLO+ara-C significantly improves patients' overall remission rate and event-free survival, with the greatest benefit in six-plus month remission patients, however, these improvements did not translate into a survival benefit compared to ara-C alone. Researchers are continuing long-term survival follow-up.

Other John Theurer Cancer Center research presented at ASCO included:

  • A phase lb study of oral panobinostat and IV bortezomib in relapsed or relapsed and refractory multiple myeloma. David S. Siegel, M.D., Ph.D., et. al.

  • The effect of carfilzomib (CFZ) in patients (Pts) with bortezomib (BTZ)-naive relapsed or refractory multiple myeloma (MM): Updated results from the PX-171-004 study. - David H. Vesole, M.D., PH.D., F.A.C.P., et. al.

  • Interim results from PX-171-006, a phase (Ph) II multicenter dose-expansion study of carfilzomib (CFZ), lenalidomide (LEN), and low-dose dexamethasone (loDex) in relapsed and/or refractory multiple myeloma (R/R MM). David S. Siegel, M.D., Ph.D., et. al.

  • A randomized, multicenter, phase (Ph) III study comparing carfilzomib (CFZ), lenalidomide (LEN), and dexamethasone (Dex) to LEN and Dex in patients (Pts) with relapsed multiple myeloma (
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Contact: Amy Leahing
Amy.leahing@zibbel.com
John Theurer Cancer Center
Source:Eurekalert

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