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John Theurer Cancer Center researchers shared 14 leading edge studies at recent ASCO meeting
Date:7/18/2011

6% for both groups). These gains were far less than for patients 65 and under (63% in the 2001-2006 group, 35% for 1988-1993 and 32% for 1994-2000). The authors suggest an in-depth review of a number of variables that may contribute to worse survival for older patients, in order to improve the design of future clinical trials.

A new predictive model based on age, pretreatment LDH, and post-therapy PET-CT in patients with MCL treated with dose-intensive strategies.

Anthony Mato, M.D. and a research team from John Theurer Cancer Center conducted a retrospective study examining risk factors associated with survival of patients with mantle cell lymphoma who were treated with dose-intensive strategies and/or high dose therapy with autologous stem cell transplant. The researchers developed an algorithm that enabled them to identify distinct prognostic subgroups, based on three variables: age, levels of LDH enzymes in the blood, and presence of disease on PET scans. With a median follow up at 35 months, they found that age ≥ 60 and the presence of disease on post-treatment PET-CT scans were associated with inferior survival. They state that their prognostic model integrates PET status post therapy with baseline clinical parameters, which might help in early identification of subsets of patients who might be treated with alternate strategies in order to improve outcomes.

The association between the GOELAMS MCL-PET prognostic index and survival in patients treated with rituximab-hypercvad (R-HyCVAD) or high-dose therapy with autologous stem cell rescue (HDT/ASCT).

In a retrospective, single-center study, Tatyana Feldman, M.D. and colleagues from John Theurer Cancer Center looked at the usefulness of an existing prognostic model known as "GOELAMS" in newly diagnosed mantle cell lymphoma patients treated with dose-intensive strategies or high dose therapy with autologous stem cell transplantation. Researchers examined the cases of 83 patients, me
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Contact: Amy Leahing
Amy.leahing@zibbel.com
John Theurer Cancer Center
Source:Eurekalert

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