Navigation Links
John Moores gives $2 million to Scripps Research to develop river blindness field test
Date:3/20/2013

expensive, simple to use, tolerant of extreme temperatures and portablebasically distilling our finding to a test that can be carted around in a backpack," said Janda. "This new gift will make that possible."

A leading cause of vision loss, Onchocerciasis infections are transmitted among humans by river-dwelling blackflies in tropical regions. The vast majority of cases occur in sub-Saharan Africa, although pockets of endemic infection exist in Yemen and in Central and South America. The major symptoms of the disease, including blindness, result from the spread of O. volvulus "microfilariae"early-stage larval wormsto the eyes and other tissues, where they trigger damaging inflammatory reactions.

Mass treatment campaigns, begun in the 1990s, have used the anti-worm drug ivermectin, as well as the antibiotic doxycycline, which kills a symbiotic bacterium within the worms. But Onchocerciasis treatment is seldom effective immediately, and often spares adult worms. The latter can remain in protected nodules under the skin of a patient and secrete microfilaria for a decade or more.

Current diagnostic methods include the painful cutting of "skin snips" from patients for microscopic analysis and an ELISA antibody test for microfilariae, which may yield positive results even for non-active infections. Health agencies need better diagnostic methods to track the progress of Onchocerciasis treatment campaigns and to wisely monitor the use of ivermectin and doxycycline to reduce the risk of resistance.

Janda envisions the new diagnostic test, which he hopes to develop over the next two years, as a simple, accurate and painless urine dipstick test, much like a home pregnancy test. The diagnostic would indicate the amount of the O. volvulus biomarker present in the sample to guide treatment decisions and assist global health leaders in their quest to eradicate the disease.


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers find mechanism that gives plants balance
2. Analysis of speed of Greenland glaciers gives new insight for rising sea level
3. Esther B. OKeeffe Foundation gives $2 million to the Scripps Research Institute
4. Exome sequencing gives cheaper, faster diagnosis in heterogeneous disease
5. New model gives hands-on help for learning the secrets of molecules
6. New brain gene gives us edge over apes, study suggests
7. New ancient shark species gives insight into origin of great white
8. Location, location, location: Membrane residence gives proteases novel abilities
9. Oscillating gel gives synthetic materials the ability to speak
10. Petri dish lens gives hope for new eye treatments
11. Colorado Marijuana Task Force Gives Green Light To "Pot Tourism"
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of the ... their offering. One major trend emerging ... systems. Multimodal biometric systems utilize more than one characteristic ...
(Date:12/10/2014)... You,ve been here before: you desperately need to sign into ... or the answer to your secret question. What,s your dog,s birthday? ... Hoyos Labs , a digital infrastructure security company, launches the ... that comes with usernames, passwords and PINs – 1U TM ...
(Date:12/10/2014)... Dec. 9, 2014 CIE San Diego has launched an ... tissue that enhances care coordination among social service and care ... a second $1 million grant from the Alliance Healthcare Foundation ... will be recognized as a "Live Well San Diego" partner ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... are exceptionally rare in the Arabian Peninsula. An international ... University, and the Saudi Geological Survey have now uncovered ... What is now dry desert was once a beach ... reptiles and dinosaurs. A string of vertebrae from ...
... stored within trees is an important area of ecological ... stores and a study in New Phytologist ... the most important factor behind the tallest species. ... carbon research, a competitive advantage as they can place ...
... Toulany et al., it was demonstrated for the first ... (as it is performed clinically) results in a reactivation ... far unknown regulatory loop via ERK1/2. This reactivation of ... tumor cell lines presenting constitutively active K-Ras activity (both ...
Cached Biology News:First dinosaurs identified from Saudi Arabia 2
(Date:1/23/2015)... 2015 Portal Solutions , a technology ... Microsoft Office 365 and SharePoint platforms , today announces ... for being one of the region’s fastest-growing mid-sized companies based ... , “To be recognized a second year in a ...
(Date:1/22/2015)... | RBJ today announces the firm brokered a long-term lease ... leading biopharmaceutical company, at Two Ledgemont Center in ... , president, and Brian Cohen , senior vice president, ... at 95 Hayden Ave. Photo - http://photos.prnewswire.com/prnh/20150122/170765 ...
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart ... 2014 was a record-breaking year across the board for the ... Smart Data Platform and our Smart Data solutions, our customers ... data which led to record growth for the company in ...
(Date:1/22/2015)... 2015 Crystal Diagnostics (CDx) Xpress System, a ... received AOAC-PTM Certifications for the six non-O157 Shiga toxin-producing E. ... referred to as STEC or the “Big-6”) as well as ... (cfu) per 325 g of raw ground beef and raw ...
Breaking Biology Technology:Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 2Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 3Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Cambridge Semantics Announces Record Results for 2014 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2
... makes a great place to work? There are many ways to ... work is one that inspires the passion of workers and unleashes ... on by what they do and who they work for or ... than the usual reasons - for something deeper and more meaningful ...
... bugbear above all: complexity. That was the view presented by ... and attendees of the Fusion2006 CEO-CIO Symposium. , ... Timons, an analysit with R.W. Baird & Co. He said ... many vendors, too many business processes, too many things to ...
... Cagigal, front right, and Harvey said they work together so ... Madison, Wis. The president and CEO of ... and the chief information officers must be "joined at the ... business. , ,William Harvey, delivering a keynote address Thursday at ...
Cached Biology Technology:What makes a "best place to work"? 2What makes a "best place to work"? 3What makes a "best place to work"? 4What makes a "best place to work"? 5Simplicity appeals to CIOs, but it's no easy task 2Simplicity appeals to CIOs, but it's no easy task 3CEOs and CIOs must be 'joined at the hip' 2CEOs and CIOs must be 'joined at the hip' 3
Ubiquitin-like protein 4A (Ubiquitin-like protein GDX). [Source:Uniprot/SWISSPROT;Acc:P11441] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
AK6 Antibody...
Reacts with the 80 kDa fragment of the M-chain of human merosin....
Goat anti-mouse gamma chain-HRP...
Biology Products: