Navigation Links
Jekyll and Hyde bacteria aids or kills, depending on chance
Date:7/5/2012

EAST LANSING, Mich. Living in the guts of worms are seemingly innocuous bacteria that contribute to their survival. With a flip of a switch, however, these same bacteria transform from harmless microbes into deadly insecticides.

In the current issue of Science, Michigan State University researchers led a study that revealed how a bacteria flips a DNA switch to go from an upstanding community member in the gut microbiome to deadly killer in insect blood.

Todd Ciche, assistant professor of microbiology and molecular genetics, has seen variants like this emerge sometimes by chance resulting in drastically different properties, such as being lethal to the host or existing in a state of mutual harmony. Even though human guts are more complex and these interactions are harder to detect, the revelation certainly offers new insight that could lead to medical breakthroughs, he said.

"Animal guts are similar to ours, in that they are both teeming with microbes," said Ciche, who worked with researchers from Harvard Medical School. "These bacteria and other microorganisms are different inside their hosts than isolated in a lab, and we're only beginning to learn how these alliances with microbes are established, how they function and how they evolve."

The bacteria in question are bioluminescent insect pathogens. In their mutualistic state, they reside in the intestines of worms, growing slowly and performing other functions that aid nematode's survival, even contributing to reproduction.

As the nematodes grow, the bacteria reveal their dark side. They flip a DNA switch and arm themselves by growing rapidly and producing deadly toxins. When the worms begin infesting insects, they release their bacterial insecticide.

"It's like fleas teaming up with the plague," Ciche said.

The question remains: What causes this dramatic transformation?

"If we can figure out why the DNA turns on and off to cau
'/>"/>

Contact: Layne Cameron
layne.cameron@cabs.msu.edu
517-353-8819
Michigan State University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Leading evolutionary scientist to discuss how genome of bacteria has evolved
2. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
3. Team discovers how bacteria resist a Trojan horse antibiotic
4. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
5. Bacterial shock to recapture essential phosphate
6. Disarming disease-causing bacteria
7. Study shows unified process of evolution in bacteria and sexual eukaryotes
8. Invisible helpers: How probiotic bacteria protect against inflammatory bowel diseases
9. Researchers develop rapid test strips for bacterial contamination in swimming water
10. Bacteria discovery could lead to antibiotics alternatives
11. Agricultural bacteria: Blowing in the wind
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Jekyll and Hyde bacteria aids or kills, depending on chance
(Date:4/18/2014)... X-ray crystallography and nuclear magnetic resonance imaging (NMR) to ... but such efforts have long been hampered by the ... molecule and often in ordered and crystalized form to ... peer into the structure of most molecules. , Harvard ... thing of the past. , A team of ...
(Date:4/18/2014)... researchers have published soil organic carbon sequestration rates. ... organic carbon can be sequestered by simply switching from ... there is a growing body of research with evidence ... cover crops, small grains, and forages may not be ... , "Some studies have shown that both moldboard and ...
(Date:4/18/2014)... as they,re planted may be good news for a garden. ... wild, a plant whose seeds sprouted at the first ,warm ... an insurance policy against late frosts or unexpected dry spells, ... Plants whose seeds put off sprouting until conditions are ... team of researchers working at the National Evolutionary Synthesis Center ...
Breaking Biology News(10 mins):MRI, on a molecular scale 2MRI, on a molecular scale 3Researchers question published no-till soil organic carbon sequestration rates 2Researchers question published no-till soil organic carbon sequestration rates 3Researchers question published no-till soil organic carbon sequestration rates 4Plants with dormant seeds give rise to more species 2
... Highlights from the 10 April Geology posting ... arc; Holocene stromatolites from Walker Lake, Nevada, USA; ammonite ... ocean wave size versus geographic variability; deep-water formation in ... the end-Triassic mass extinction; and "foreign" magma in early ...
... more Pacific salmon to spawn in coastal streams will not ... also lead to more salmon in the ocean and thus ... and humans. In a new article and accompanying synopsis published ... , Taal Levi and co-authors from UC Santa Cruz and ...
... USA -- April 10, 2012 -- HUNT Biosciences and ... the clinical use of protein biomarkers, with an initial ... of cardiovascular events such as strokes, heart attacks, and ... and clinical data from HUNT Biosciences using SomaLogic,s unique ...
Cached Biology News:Mafic melts, methane seeps, 2 million waves, foreign magma, and the invisible hand 2Mafic melts, methane seeps, 2 million waves, foreign magma, and the invisible hand 3Mafic melts, methane seeps, 2 million waves, foreign magma, and the invisible hand 4Mafic melts, methane seeps, 2 million waves, foreign magma, and the invisible hand 5Mafic melts, methane seeps, 2 million waves, foreign magma, and the invisible hand 6Mafic melts, methane seeps, 2 million waves, foreign magma, and the invisible hand 7Mafic melts, methane seeps, 2 million waves, foreign magma, and the invisible hand 8Mafic melts, methane seeps, 2 million waves, foreign magma, and the invisible hand 9Why letting salmon escape could benefit bears and fishers 2
(Date:1/14/2014)... iLab Solutions, the leader in core facility management software, ... Strategy. In this role, Michelle will work with current and ... the development of iLab products. Her main goal will be ... the scientific community by offering the most advanced, user-friendly, and ...
(Date:1/14/2014)... January 14, 2014 Global Record ... innovative information technology solutions for patients, physicians, the ... stakeholders, announced today the signing of a three-year ... and Drug Administration (FDA). This initiative is ...
(Date:1/14/2014)... 14, 2014 Kerr Corporation, a leading manufacturer ... additional how-to information about dual arch impressions on its dental ... Arch Impressions,” the blog entry serves up a list of ... a step-by-step demonstration by Dr. David Little as he crafts ...
(Date:1/14/2014)... Research Triangle Park, NC (PRWEB) January 14, 2014 ... diagnostic company focusing on ultra-sensitive POC diagnostic platforms and novel ... on their first round of financing netting a total of ... first outside equity capital in the company. This group of ...
Breaking Biology Technology:iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2BioMedomics, Inc. Closes $690K Round of Financing 2
... ... ... ... VANCOUVER , March 16 /PRNewswire/ - Kinexus Bioinformatics Corporation, a world leader in functional proteomics research, announced the launch of a new peptide synthesis ...
... ... , ... Imagine plugging a microscope into the USB port of your PC or laptop and viewing ... microscopes from Cole-Parmer offer just this portability, convenience, and versatility. The most recent model ...
... March 15 The American Recovery and Reinvestment ... the award today of a four-year, $10.3 million ... enhance the quality and reach of the state,s existing health ... and reduce costs across the continuum of health care. The ...
Cached Biology Technology:Kinexus Announces the Launch of New Peptide Production Services 2The Latest in Digital USB Microscopes from Cole-Parmer 2Indiana Collaborative Receives $10.3 Million in Federal Stimulus Funds to Improve Healthcare through Information Technology 2Indiana Collaborative Receives $10.3 Million in Federal Stimulus Funds to Improve Healthcare through Information Technology 3Indiana Collaborative Receives $10.3 Million in Federal Stimulus Funds to Improve Healthcare through Information Technology 4Indiana Collaborative Receives $10.3 Million in Federal Stimulus Funds to Improve Healthcare through Information Technology 5Indiana Collaborative Receives $10.3 Million in Federal Stimulus Funds to Improve Healthcare through Information Technology 6Indiana Collaborative Receives $10.3 Million in Federal Stimulus Funds to Improve Healthcare through Information Technology 7
Rat neural stem cell kits are intended for the in vitro growth and commitment to neuronal and glial lineage differentiation, of cultured fetal rat neural stem and progenitor cells expanded using FGF-...
... magnetic separator for six microtubes ... conjunction with the Captivate ferrofluid ... other magnetic particles and can ... tubes. Cell Biology Cell Separation ...
Antibodies were affinity purified using epitopes specific to JLP immobilized on solid support....
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure Grade DAPI is greater than or equal to 98% pure by HPLC....
Biology Products: