Navigation Links
Jefferson urologists studying regenerated neo-bladder to help spinal cord injury patients
Date:10/5/2007

Urologists at Thomas Jefferson University Hospital are studying whether a neo-bladder construct grown from a patients own cells can improve bladder function for adult spinal cord injury patients.

Jefferson is only one of six sites in the U.S. enrolling participants in this clinical trial for the lab-grown neo-bladder construct that will involve a total of 10 patients.

Its never been done in adults before, said primary investigator Patrick Shenot, M.D., instructor in Urology, Jefferson Medical College of Thomas Jefferson University, noting that a similar study is being conducted with children with spina bifida.

The neo-bladder constructs are being developed by Tengion, Inc. in their pilot manufacturing facility.

Each neo-bladder construct consists of a biodegradable scaffold seeded with urothelial and smooth muscle cells cultured in Tengions facility from the patients own bladder cells.

To participate in the study, a patient must be 18 to 65 years of age, have had a spinal cord injury for more than a year and diagnosed with a neurogenic bladder that is not adequately responding to medical therapy.

The urologist first performs a biopsy on the patient to retrieve the cells. The cells are then sent to Tengions manufacturing facility where they are grown in culture and then seeded onto a biodegradable scaffold in the shape of a bladder.

Then, the patient returns to hospital and the urologist will implant the neo-bladder construct in a procedure known as augmentation cystoplasty or bladder augmentation.

The neo-bladder is expected to continue to regenerate within the patient, using the bodys inherent regenerative capabilities, and if successful may result in improved bladder function, Dr. Shenot noted.

The field of regenerative medicine is anticipated to be an area of intense interest and expansion in the coming years, said Dr. Shenot.

While this first trial in adults is for pat
'/>"/>

Contact: Jeff Baxt
jeffrey.baxt@jefferson.edu
215-955-5507
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Jefferson Virologists Coax HIV Out of Hiding
2. Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
3. Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method
4. Jefferson scientists identify gene defect leading to abnormal skin development and cancer
5. Jefferson researchers building a better rabies vaccine
6. Jefferson scientists identify gene mutation potentially involved in breast cancer initiation
7. Immune cell communication key to hunting viruses, Jefferson immunologists show
8. Jefferson researchers uncover new way nature turns genes on and off
9. Jefferson scientists find aging gene also protects against prostate cancer development
10. Jefferson scientists find high glucose before surgery raises risk of dangerous complications
11. Jefferson researchers discovery may change thinking on how viruses invade the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... new book that brings together two of the major ... profile of insect fossils through stunning photographs and unique ... James E Jepson, details the incredible preservation and diversity ... scene for what these remarkable fossils can tell us ... future of our planet. Like the mosquito in Jurassic ...
(Date:7/29/2014)... Many different types of cell, including sperm, bacteria ... as flagella. These protrusions, about one-hundredth of a ... move through fluid. Similar, shorter structures called cilia ... where they perform roles such as moving liquids ... are remarkably versatile: they transport mucus and expel ...
(Date:7/28/2014)... About 100 drugs already approved by the U.S. Food ... prevent the growth of certain bacterial pathogens inside human ... Mediterranean spotted fever. The findings, published in mBio ... for Microbiology, demonstrate a new way of identifying non-antibiotic ... , A handful of drugs on the list ...
Breaking Biology News(10 mins):Unique images bring fossil insects back to life 2Microscopic rowing -- without a cox 2Microscopic rowing -- without a cox 3New route to identify drugs that can fight bacterial infections 2
... as many infant deaths than previously estimated, according to a ... Control and Prevention. , The analysis, published today in Pediatrics, ... 37 completed weeks gestation, contributed to more than one-third of ... "We have long known that babies born too soon face ...
... store iron, a valuable discovery for scientists working to improve ... worldwide problem of iron deficiency and malnutrition in humans. , ... vascular system of the seed of Arabidopsis, a model plant ... vacuole, a plant cell's central storage site. The researchers also ...
... University of Manchester researchers are recruiting people with backache ... ?in the first ever study to discover if therapeutic ... and his team at the University's Centre for Rehabilitation ... sciatica for less than 12 weeks, are not pregnant ...
Cached Biology News:New study: Preterm birth causes one-third of all infant deaths 2Plant studies reveal how, where seeds store iron 2
(Date:7/29/2014)... 29, 2014 July 29, 2014 ... in the biotechnology industry, announced that it has ... Inc. to explore financing opportunities that build shareholder ... breakthrough vaccine platform with the potential to transform ... exclusively licensed the well-established LAMP platform from Johns ...
(Date:7/29/2014)...  Sigma-Aldrich Corporation (NASDAQ: SIAL ) dramatically ... investment in Green Chemistry and donated more than 8,000 ... the Company announced Monday in its new 2013 ... The report comes in a year ... responsible corporate citizen, including recognition for the second consecutive ...
(Date:7/29/2014)... -- United Therapeutics Corporation (NASDAQ: UTHR ... the second quarter ended June 30, 2014. ... medicines are reaching increasing numbers of patients ... Martine Rothblatt, Ph.D., United Therapeutics, Chairman and ... quarter of our extended-release tablet called Orenitram ...
(Date:7/29/2014)... 29, 2014 Eppendorf Centrifuge 5427 ... selection. Eppendorf 5427 R is geared towards high-end applications ... it is targeted towards work requiring high sample throughput. ... as it compliments their extensive 16, 48, and 64 ... microcentrifuge tubes, PCR tubes, PCR strip tubes, and more. ...
Breaking Biology Technology:Immunomic Therapeutics Engages Newport Coast Securities, Inc. 2Immunomic Therapeutics Engages Newport Coast Securities, Inc. 3Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 2Sigma-Aldrich Achieves Record Success in Environmental, Community Initiatives 3United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 2United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 3United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 4United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 5United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 6United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 7United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 8United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 9United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 10United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 11United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 12United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 13International Pipette Distributor, Pipette.com Announces the Addition of the Eppendorf Centrifuge 5427 R to Their Product Portfolio 2
... 24 The Charlotte-Mecklenburg region,certainly has not been immune ... NC Free Clinic Association has seen their highest,demand for ... creator of,Charlotte,s premier health & wellness event, the Charlotte ... , "We can all have ...
... Extensive Experience In Molecular DiagnosticsSALT LAKE CITY, Feb. ... spine care through the development of molecular diagnostic ... has joined the executive management team as the ... Dr. Macina will report directly to Kenneth Ward, ...
... Ore. Researchers have identified the gene that ultimately ... that could some day lead to the repair of ... restoration or even the production of replacement teeth. , ... was already known to have several functions - in ...
Cached Biology Technology:Charlotte Anti-Aging Expo & Symposium Supports Free Clinics 2Axial Biotech Appoints Dr. Roberto Macina to Vice President of Research and Development 2Genetic discovery could lead to advances in dental treatment 2
adult...
DNA Purification...
Porcine Serum Available Anticoagulants: N-02: Citrate N-04: Heparin (Na) N-06: K2EDTA N-08: Potassium Oxalate N-10: EDTA (Na) N-03: Alsevers N-05: ACD N-07: CPD N-09: K3EDTA N-11...
Recombinant Viral CCI/Fc Chimera, CF...
Biology Products: