Navigation Links
Jefferson urologists studying regenerated neo-bladder to help spinal cord injury patients
Date:10/5/2007

Urologists at Thomas Jefferson University Hospital are studying whether a neo-bladder construct grown from a patients own cells can improve bladder function for adult spinal cord injury patients.

Jefferson is only one of six sites in the U.S. enrolling participants in this clinical trial for the lab-grown neo-bladder construct that will involve a total of 10 patients.

Its never been done in adults before, said primary investigator Patrick Shenot, M.D., instructor in Urology, Jefferson Medical College of Thomas Jefferson University, noting that a similar study is being conducted with children with spina bifida.

The neo-bladder constructs are being developed by Tengion, Inc. in their pilot manufacturing facility.

Each neo-bladder construct consists of a biodegradable scaffold seeded with urothelial and smooth muscle cells cultured in Tengions facility from the patients own bladder cells.

To participate in the study, a patient must be 18 to 65 years of age, have had a spinal cord injury for more than a year and diagnosed with a neurogenic bladder that is not adequately responding to medical therapy.

The urologist first performs a biopsy on the patient to retrieve the cells. The cells are then sent to Tengions manufacturing facility where they are grown in culture and then seeded onto a biodegradable scaffold in the shape of a bladder.

Then, the patient returns to hospital and the urologist will implant the neo-bladder construct in a procedure known as augmentation cystoplasty or bladder augmentation.

The neo-bladder is expected to continue to regenerate within the patient, using the bodys inherent regenerative capabilities, and if successful may result in improved bladder function, Dr. Shenot noted.

The field of regenerative medicine is anticipated to be an area of intense interest and expansion in the coming years, said Dr. Shenot.

While this first trial in adults is for patients with bladder control problems due to spinal cord injury, the possibilities for expansion into oncology related areas are promising, he said.


'/>"/>

Contact: Jeff Baxt
jeffrey.baxt@jefferson.edu
215-955-5507
Thomas Jefferson University
Source:Eurekalert

Related biology news :

1. Jefferson Virologists Coax HIV Out of Hiding
2. Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
3. Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method
4. Jefferson scientists identify gene defect leading to abnormal skin development and cancer
5. Jefferson researchers building a better rabies vaccine
6. Jefferson scientists identify gene mutation potentially involved in breast cancer initiation
7. Immune cell communication key to hunting viruses, Jefferson immunologists show
8. Jefferson researchers uncover new way nature turns genes on and off
9. Jefferson scientists find aging gene also protects against prostate cancer development
10. Jefferson scientists find high glucose before surgery raises risk of dangerous complications
11. Jefferson researchers discovery may change thinking on how viruses invade the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2017)... 2017 NXT-ID, Inc. (NASDAQ: NXTD ) ... of its 2016 Annual Report on Form 10-K on Thursday April ... ... in the Investor Relations section of the Company,s website at ... at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... to expand at a CAGR of 25.76% during the ... is the primary factor for the growth of the ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem ... technology, application, and geography. The stem cell market of ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... ... ... G-CON today announced that it has received Notices of ... 14/858,857 and 13/669,785 both entitled Modular, Self-Contained, Mobile Clean Room. The U.S. Patent ... G-CON’s R&D investments and validate the G-CON platform as a novel way to ...
(Date:7/18/2017)... ... 2017 , ... Allotrope Foundation won the 2017 in Knowledge ... Allotrope Framework for commercial use. , The Bio-IT World Best Practices Awards ... critical role of information technology in modern biomedical research, but also to highlight ...
(Date:7/17/2017)... ... 2017 , ... Whitehouse Laboratories is excited to announce that ... series of ISO 80369 standard test procedures. The ISO 80369 series of eight ... systems. With this recent expansion, Whitehouse Labs becomes one of the only facilities ...
(Date:7/17/2017)... ... July 17, 2017 , ... ... today announced safety software company AB Cube has joined its eHealth ... to advance technology innovation across life sciences and healthcare. Under the partnership, ...
Breaking Biology Technology: