Navigation Links
Jefferson scientists identify a new protein involved in longevity
Date:5/7/2010

(PHILADELPHIA) Researchers in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University have found that the level of a single protein in the tiny roundworm C. elegans determines how long it lives. Worms born without this protein, called arrestin, lived about one-third longer than normal, while worms that had triple the amount of arrestin lived one-third less.

The research also showed that arrestin interacts with several other proteins within cells to regulate longevity. The human version of one of these proteins is PTEN, a well-known tumor suppressor. The study, to be published in the online edition of the Journal of Biological Chemistry, was chosen by the journal as the "Paper of the Week" considered in the top one percent of published articles.

Because most proteins in worms have human counterparts, these findings may have relevance to human biology and the understanding of cancer development, said Jeffrey L. Benovic, Ph.D., professor and chair of the department.

"The links we have found in worms suggest the same kind of interactions occur in mammals although human biology is certainly more complicated. We have much work to do to sort out these pathways, but that is our goal," said Dr. Benovic.

Researchers use the roundworm as a model because it offers a simple system to study the function of genes and proteins that are relevant to human biology. The worm, for example, has one arrestin gene, whereas humans have four. Worms only have 302 neurons compared to the 100 billion or so in the human brain. In addition, their short lifespan of two to three weeks allows for timely observation of effects on longevity.

Dr. Benovic and the study's first author, Aimee Palmitessa, Ph.D., a postdoctoral research fellow, studied signaling pathways activated by G protein-coupled receptors. These receptors bind to all kinds of hormones, sensory stimuli (such as light, odorants and tastants),
'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-6300
Thomas Jefferson University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Jefferson urologists studying regenerated neo-bladder to help spinal cord injury patients
2. Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
3. Jefferson receives $11.6M NIH grant to study novel mechanisms of heart failure
4. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
5. Jefferson Department of Surgery announces new pancreas tumor registry
6. Jefferson scientists discover a key protein regulator of inflammation and cell death
7. Jefferson researcher awarded Landenberger Foundation grant for ALS research
8. Jefferson receives $1.7 million grant to study stem cells in intervertebral discs of the spine
9. US Department of State names UCR entomologist a Jefferson Science Fellow
10. UK scientists working to help cut ID theft
11. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... cooks are turning to more healthful alternatives to their ... sometimes mean low satisfaction. Now researchers are reporting new ... that are made with olive oil rather than pork ... of Agricultural and Food Chemistry . , Ana M. ... to expect just the right amount of chewiness and ...
(Date:7/9/2014)... sparrow-sized fossil from China challenges the commonly held belief ... the ability to fly. The birdlike fossil is actually ... the remains of a tiny tree-climbing animal that could ... Museum in Blanding, Utah, and Alan Feduccia of the ... Journal of Ornithology . , The fossil of ...
(Date:7/9/2014)... developed by researchers at the NIH,s National ... its collaborators to treat sickle cell disease ... business. The drug candidate, Aes-103, is the ... molecular mechanism of sickle cell disease. Baxter ... required for regulatory approval and commercialization. , ...
Breaking Biology News(10 mins):Researchers declassify dinosaurs as being the great-great-grandparents of birds 2First drug candidate from NIH program acquired by biopharmaceutical company 2First drug candidate from NIH program acquired by biopharmaceutical company 3First drug candidate from NIH program acquired by biopharmaceutical company 4
... Elsevier, a world-leading provider of scientific, technical and ... a new, international, open access journal, Case Studies ... Studies in Engineering Failure Analysis provides a forum ... Studies in Engineering Failure Analysis and will form ...
... of several of the most external atomic layers of ... Analysis by a number of modern techniques. Just opened ... Academy of Sciences, Warsaw, Poland, the Centre provides a ... electron microscope and specialised spectroscopic equipment for surface studies ...
... PHOENIX, Nov. 26, 2012 Webcast AdvisoryWhat:Announcement of a ... internationally respected team racing to unlock genomic codes ... lead to biomedical breakthroughs that will give new ... diagnoses.Who:Phoenix Children,s Hospital, in collaboration with Translational Genomics ...
Cached Biology News:Elsevier launches new open access journal -- 'Case Studies in Engineering Failure Analysis' 2Surface analysis techniques for advanced materials enhance Mazovia's research potential 2Surface analysis techniques for advanced materials enhance Mazovia's research potential 3
(Date:1/15/2014)... The Pittcon Organizing Committee is pleased to announce ... , an e-Journal and producer of Food Labs ... year for the co-location of Food Labs Conference to be ... the registration fee to attend the two-day Food Lab Conference, ...
(Date:1/15/2014)... Look inside the new Preferred Solutions® ... lab, from fluid handling to instruments to supplies. Many ... you order. , Preferred Solutions features a full ... L/S® model for precise flow control and dispensing to ...
(Date:1/15/2014)... OXFORD, England and SAN JOSE, California ... an international biotechnology company developing antibody-drug conjugates for cancer, today ... its Board of Directors. Dr Reynolds has over 20 years, ... Chief Medical Officer at Seattle Genetics. "I am ...
(Date:1/15/2014)... 15, 2014 This webinar will focus ... clinical safety assessment in biosimilars. , Regulatory frameworks are ... drug development, however the complex nature of biopharmaceuticals makes ... and efficacy extremely challenging. Based on the specific aspects ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2
... everyone has heard of identity theft (IDT), yet unless you ... at high risk. An alarming figure is that over half ... a place of business, employer, or other entity (not-for-profit or ... individuals are required under one or more federal and state ...
... American angel investors continue to be the largest source of ... in the first half of 2006, an increase of 15 ... Center for Venture Research at the University of New ... research on the angel market since 1980, reported that healthcare ...
... had a crystal ball that could help him predict the ... president and research fellow at Yahoo , has a ... called "the cash cow with a big target on it." ... user-generated content (combined with search) that will somehow enable professionals ...
Cached Biology Technology:Identity theft: The business time bomb 2Identity theft: The business time bomb 3Identity theft: The business time bomb 4Angel investors commit $12.7B in first half of `06 2Online communities may be next business market 2Online communities may be next business market 3
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
CD69/CD3 50 tests...
Mouse monoclonal [3F8 ] to smooth muscle Myosin heavy chain I ( Abpromise for all tested applications). entrezGeneID: 4629 SwissProtID: P35749...
Rabbit polyclonal to pCrosstide (HRP) ( Abpromise for all tested applications)....
Biology Products: