Navigation Links
Jefferson scientists identify a new protein involved in longevity
Date:5/7/2010

(PHILADELPHIA) Researchers in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University have found that the level of a single protein in the tiny roundworm C. elegans determines how long it lives. Worms born without this protein, called arrestin, lived about one-third longer than normal, while worms that had triple the amount of arrestin lived one-third less.

The research also showed that arrestin interacts with several other proteins within cells to regulate longevity. The human version of one of these proteins is PTEN, a well-known tumor suppressor. The study, to be published in the online edition of the Journal of Biological Chemistry, was chosen by the journal as the "Paper of the Week" considered in the top one percent of published articles.

Because most proteins in worms have human counterparts, these findings may have relevance to human biology and the understanding of cancer development, said Jeffrey L. Benovic, Ph.D., professor and chair of the department.

"The links we have found in worms suggest the same kind of interactions occur in mammals although human biology is certainly more complicated. We have much work to do to sort out these pathways, but that is our goal," said Dr. Benovic.

Researchers use the roundworm as a model because it offers a simple system to study the function of genes and proteins that are relevant to human biology. The worm, for example, has one arrestin gene, whereas humans have four. Worms only have 302 neurons compared to the 100 billion or so in the human brain. In addition, their short lifespan of two to three weeks allows for timely observation of effects on longevity.

Dr. Benovic and the study's first author, Aimee Palmitessa, Ph.D., a postdoctoral research fellow, studied signaling pathways activated by G protein-coupled receptors. These receptors bind to all kinds of hormones, sensory stimuli (such as light, odorants and tastants),
'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-6300
Thomas Jefferson University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Jefferson urologists studying regenerated neo-bladder to help spinal cord injury patients
2. Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
3. Jefferson receives $11.6M NIH grant to study novel mechanisms of heart failure
4. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
5. Jefferson Department of Surgery announces new pancreas tumor registry
6. Jefferson scientists discover a key protein regulator of inflammation and cell death
7. Jefferson researcher awarded Landenberger Foundation grant for ALS research
8. Jefferson receives $1.7 million grant to study stem cells in intervertebral discs of the spine
9. US Department of State names UCR entomologist a Jefferson Science Fellow
10. UK scientists working to help cut ID theft
11. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... the international Cancer Genomics of the Kidney consortium ... kidney cancer and exposure to aristolochic acid, an ... in Nature Communications , have important implications ... than 140,000 people every year, and in Central ... part of the International Cancer Genome Consortium (ICGC), ...
(Date:10/28/2014)... Scientists from North America, Europe and China have published ... Academy of Sciences that reveals important details about ... our planet., From strange and exotic algae, mosses, ferns, ... the grains and vegetables we eat and the ornamental ... shares over a billion years of history., "Our study ...
(Date:10/28/2014)... Technological University Singapore (NTU Singapore) will be building ... renewable energy sources. , The first in the ... the integration of solar, wind, tidal-current, diesel, storage ... operate well together. , To be built under ... initiative, the hybrid micro-grid will be located offshore ...
Breaking Biology News(10 mins):Kidney cancer in Central Europe 2New study uses DNA sequences to look back in time at key events in plant evolution 2New study uses DNA sequences to look back in time at key events in plant evolution 3NTU to build region's first renewable energy integration demonstration micro-grid 2NTU to build region's first renewable energy integration demonstration micro-grid 3
... condition that can appear after breast cancer surgery, ... survivors. Although lymphedema can cause lifelong swelling in ... no national standard of diagnosis or care. Now, ... Lymphedema Framework Project (ALFP), a national, multi-disciplinary collaboration ...
... Inc. has obtained a non-exclusive license to make ... developed at Case Western Reserve University,s Department of ... Center in Cleveland. The ... based in Indiana, Pa., rights to intramuscular recording ...
... Food packaging and other disposable plastic items could soon be ... new sugar-based polymer. The degradable polymer is made ... crops such as fast-growing trees and grasses, or renewable biomass ... at Imperial College London by a team of Engineering and ...
Cached Biology News:Researchers develop standard of care for breast cancer survivors with lymphedema 2Compostable plastics have a sweet ending 2
(Date:10/30/2014)... (PRWEB) October 30, 2014 Whitehouse Laboratories ... its ICH Stability Testing and Package Test Capacity. Responding ... centers on a dramatic increase in environmental chamber storage ... stability, storage and aging samples to be securely held ... this major capital expenditure has already taken place with ...
(Date:10/30/2014)... 30, 2014 Isis Pharmaceuticals, Inc. (NASDAQ: ... management will present a company overview at the Nomura Biotechnology ... in Boston, MA. A ... "Investors & Media" section of the Company,s website, www.isispharm.com ... within 48 hours and will be archived for a limited ...
(Date:10/30/2014)... of the key challenges in the development of quantum ... , In a paper published today (28 October) in ... show how to make a new type of flexibly ... such as high-precision sensors and specialised superfast computers, often ... the methods for trapping these tiny particles are hugely ...
(Date:10/27/2014)... 2014 The new research report, ... & Medium), Sub-type (Primary & Secondary), and End-User ... Transportation & Power Generation) - Trends and Forecasts ... with analysis and forecasting of the market size. ... with 52 Figures spread through 146 Pages and ...
Breaking Biology Technology:Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 3Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 4
... July 15 Amsterdam,Molecular Therapeutics (Euronext: AMT), a ... announced the start of a collaboration with St. ... the development,of a gene therapy treatment for Hemophilia ... commercial rights to the final product. The,combination of ...
... A report published in the July 8 issue of ... Sciences ( PNAS ) is the first to ... of tiny nanoclusters of metallic gold. The study, which ... the work of researchers at four universities on two ...
... HealthSonix, Inc.,(Pink Sheets: HSXI)(FWB:H7S) today announced that ... purchased two wholly owned,subsidiaries of HealthSonix, Inc. ... "Selling the two operating companies to Innovative ... the companies to,resume full operations and get ...
Cached Biology Technology:AMT Starts Collaboration With St. Jude Children's Research Hospital on Gene Therapy for Hemophilia B. Company Accesses Exclusive Commercial Rights to Final Therapy 2AMT Starts Collaboration With St. Jude Children's Research Hospital on Gene Therapy for Hemophilia B. Company Accesses Exclusive Commercial Rights to Final Therapy 3AMT Starts Collaboration With St. Jude Children's Research Hospital on Gene Therapy for Hemophilia B. Company Accesses Exclusive Commercial Rights to Final Therapy 4Study reveals principles behind stability and electronic properties of gold nanoclusters 2Study reveals principles behind stability and electronic properties of gold nanoclusters 3Study reveals principles behind stability and electronic properties of gold nanoclusters 4HealthSonix Sells Operating Subsidiaries to Innovative Health Sciences 2
... Johnstone and M.W. Turner ... describes step-by-step methods for ... relevant molecules, the use ... specific analytical probes and ...
Request Info...
LabFax: Immunochemistry...
Edited by P.J. Delves (1997) An up-to-date review of antibody-raising technologies, this volume provides researchers with immediate access to the protocols they require every day....
Biology Products: