Navigation Links
Jefferson researchers unlock key to personalized cancer medicine using tumor metabolism
Date:4/15/2011

es. It appears that these metabolites increase "stemness" in cancer cells, which drives poorer outcomes.

"Tumors that are using the body's own nutrients (lactate and ketones) as "fuel" have a poorer outcome for patient survival, a behavior that now can be used to predict if a patient is at a high-risk for recurrence or metastasis," Dr. Lisanti said. "This is getting to the heart of personalized cancer medicine. Now, we have identified a panel of biomarkers that directly links cancer metabolism with targeted cancer therapy."

These findings suggest, according to the authors, that high-risk cancer patients (those whose cancer cells use high-energy metabolites) can be treated with new therapeutics that target oxidative mitochondrial metabolism, such as the antioxidant metformin, a drug that is also used to treat diabetes.

"Knowing the gene signatures of patients whose cancer cells are "eating" these metabolites (lactate and ketones) for fuel is a pivotal piece of new information that we can use to diagnose and treat cancer patients," said Martinez-Outschoorn, M.D., of the department of Medical Oncology at Thomas Jefferson University, and the lead author of the paper. "It's not just that we know those patients will have poor survival; we know that those patients are using mitochondrial metabolism, which is the type of energy metabolism that we should be targeting with new anti-cancer drugs."

The researchers propose that this new approach to diagnosis and subsequent treatment be called "Metabolo-Genomics" since it incorporates both cell metabolism and gene transcriptional profiling. This strategy could now be used to direct which patients receive a particular "tailored" anti-metabolic therapy.

Genetic markers, like expression of the mutationally activated HER2 gene, provide biomarkers that can be used to identify breast cancer patients at high-risk for recurrence or metastasis, and to modify their subsequent treatment with ta
'/>"/>

Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Jefferson Department of Surgery announces new pancreas tumor registry
3. Jefferson scientists discover a key protein regulator of inflammation and cell death
4. Jefferson researcher awarded Landenberger Foundation grant for ALS research
5. Jefferson receives $1.7 million grant to study stem cells in intervertebral discs of the spine
6. US Department of State names UCR entomologist a Jefferson Science Fellow
7. Jefferson scientists identify a new protein involved in longevity
8. Jefferson receives $3 million NIH grant to study molecular and genetic mechanisms in platelets
9. Jefferson researchers receive W.W. Smith Charitable Trust
10. Jefferson researchers provide genetic evidence that antioxidants can help treat cancer
11. Nature study: Jefferson researchers unravel proteins elusive role in embryo and disease development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... learned a great deal about complex social behavior by ... something to teach too. , With their unusually large ... parrots live in a complex social environment---not merely in ... or ants, but in a dynamic setting of alliances ... intelligent mammals: dolphins, whales, primates, and social carnivores, like ...
(Date:9/16/2014)... Environmental Health at the Mailman School of Public Health ... asthma and prenatal exposure to two phthalates used in ... in the journal Environmental Health Perspectives . ... higher levels of the chemicals, butylbenzyl phthalate (BBzP) and ... percent increase in risk of developing asthma between age ...
(Date:9/16/2014)... Menopause Society (NAMS) has published its key, evidence-based ... everything from hot flashes to heart disease. The ... for Clinical Care of Midlife Women," was published ... . This is the first, comprehensive set of ... freely available to all clinicians who care for ...
Breaking Biology News(10 mins):Being social: Learning from the behavior of birds 2Phthalates heighten risk for childhood asthma 2Phthalates heighten risk for childhood asthma 3
... -- In the summer of 1968, a new strain of ... spread around the globe and eventually killed an estimated 1 ... there are many strains of H3N2 circulating in birds and ... have the potential to generate a pandemic if they leap ...
... from the David Geffen School of Medicine at UCLA have ... of Sciences in recognition of their distinguished and continuing achievements ... is considered one of the highest honors presented to scientists ... Thomas Edison, Orville Wright and Alexander Graham Bell. ...
... a new door to developing drugs to slow the ... Edward A. Fon at the Montreal Neurological Institute and ... in the Department of Biochemistry at the Faculty of ... Parkin. Mutations in Parkin cause a rare hereditary form ...
Cached Biology News:Potential flu pandemic lurks 2Potential flu pandemic lurks 32 UCLA faculty elected to National Academy of Sciences 2Unleashing the watchdog protein 2
(Date:9/17/2014)... Beckman Coulter , a global ... has renewed its agreement with Personify for ... agreement, Personify will continue to streamline the Beckman Coulter ... analytics, including time-to-fill, time-to-source and a deep reduction to ... Personify was based on the success of our partnership ...
(Date:9/17/2014)... 2014 NASA’s MESSENGER has just celebrated ... is proud to have one of its latch valves, ... is a scientific investigation of the planet Mercury. It ... there, and has provided a vast amount of information ... of latch valves utilize solenoids that also include permanent ...
(Date:9/16/2014)... “Nature has developed, very cleverly, some ... desire in optical design,” said Joseph Shaw, director of ... we explore surfaces and structures at the nanoscale, we’ll ... in San Diego in August during a conference called ... chaired by Shaw and Rongguang Liang of the University ...
(Date:9/16/2014)... SAN DIEGO , Sept. 16, 2014  Biocom, ... life science community, recognizes the 9 th ... to the value of IT technologies in improving our ... California is one of the world,s most ... from EHRs to mobile health applications to genomic testing ...
Breaking Biology Technology:Beckman Coulter Signs 3-year RPO Contract with Personify 2Beckman Coulter Signs 3-year RPO Contract with Personify 3Nature’s designs inspire research into new light-based technologies 2Nature’s designs inspire research into new light-based technologies 3Nature’s designs inspire research into new light-based technologies 4Nature’s designs inspire research into new light-based technologies 5Biocom Recognizes National Health IT Week 2
... HUBBARD, Ohio, Jan. 8 NanoLogix, Inc. (OTC:,NNLX), ... the company,has been named "Stock Pick of January ... vice president, stated,that "This is another example of ... We are happy to be selected by Stockprowler,-- ...
... 1 Clinical Trial -, MADISON, Wis., Jan. 8 ... develops products to detect,treat and monitor human cancers, today ... offering. Cellectar will use the money to continue,operations and ... oncology,product candidate, CLR1404, which is planned to start this ...
... strengthen Elekta,s offering and accelerate the company,s expansion into ... high growth ... (publ) (STO: EKTAb),a world leader in clinical solutions for radiation ... based on,a Letter of Intent to acquire CMS Inc. for ...
Cached Biology Technology:NanoLogix, Inc. Makes Stock Pick List 2Cellectar, Inc. Raises $13 Million in Private Offering 2Cellectar, Inc. Raises $13 Million in Private Offering 3Elekta Negotiates To Acquire CMS 2Elekta Negotiates To Acquire CMS 3Elekta Negotiates To Acquire CMS 4Elekta Negotiates To Acquire CMS 5
... R&D Systems Cell and Tissue Staining Kits ... a broad range of histological and cytological ... primary IgG antibodies manufactured by either R&D ... is based on the formation of the ...
... measurements in an easy-to-use benchtop package. ... spectrometer (ESI-oa-TOF) concentrates the performance of ... which fits on your bench. The ... 10,000 FWHM and mass accuracy of ...
... Cellular uptake of long double stranded ... RNA interference in a diverse group of ... culture. RNA interference leads to the inhibition ... destruction of the target messenger RNA (mRNA). ...
... and Bruker BioSpins Metabolic Profiler is ... and analysis of complex mixtures. It ... optional Avance NMR spectrometer and integrated ... statistical analysis for applications like:,Assessment of ...
Biology Products: