Navigation Links
Jefferson researchers receive W.W. Smith Charitable Trust
Date:11/8/2010

PHILADELPHIA Molecular biologist Jonathan Brody, Ph.D., assistant professor, Department of Surgery; and Gregory E. Goney, Ph.D., research assistant professor, and member of the Daniel Baugh Institute for Functional Genomics/Computational Biology in the Department of Pathology, Anatomy and Cell Biology at Jefferson Medical College of Thomas Jefferson University have been awarded a W.W. Smith Charitable Trust medical research grant. This one-year grant awards $100,000 to their group to help support their innovative cancer research, and one of the questions they will address is why African-Americans respond poorly to common chemotherapeutic agents used to treat pancreatic cancer. Another question this grant will address is what genes in cancer cells are regulated upon stressful conditions such as chemotherapeutic treatments..

Dr. Brody will use the funding to build upon his research involving a stress-response protein called Hu antigen R (HuR), which helps pancreatic tumor cells survive. Previously, Dr. Brody and his team have identified the molecular mechanism by which HuR regulates gemcitabine (a commonly used drug used to treat this disease). Recently, the team has discovered a unique DNA sequence alteration that resides in the HuR-interacting site of deoxycytidine kinase, the gemcitabine activating enzyme. This one base pair sequence change, also known as a polymorphism (SNP), is highly prevalent in the African-American population (over 65 percent); it is considerably less common in the Caucasian population (5 percent). From preliminary data, this sequence change may explain why African Americans respond poorly to standard of care therapy of pancreatic cancer.

"Our early findings are very exciting. It's our hope that further validation and exploration of this particular polymorphism may ultimately result in a simple test that could improve therapy and outcomes for African Americans with this deadly disease," said Dr. Brody.

A
'/>"/>

Contact: Ed Federico
ed.federico@jefferson.edu
Thomas Jefferson University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Jefferson Department of Surgery announces new pancreas tumor registry
3. Jefferson scientists discover a key protein regulator of inflammation and cell death
4. Jefferson researcher awarded Landenberger Foundation grant for ALS research
5. Jefferson receives $1.7 million grant to study stem cells in intervertebral discs of the spine
6. US Department of State names UCR entomologist a Jefferson Science Fellow
7. Jefferson scientists identify a new protein involved in longevity
8. Jefferson receives $3 million NIH grant to study molecular and genetic mechanisms in platelets
9. NC State researchers get to root of parasite genome
10. Researchers find animal with ability to survive climate change
11. Researchers find an essential gene for forming ears of corn
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... PULLMAN, Wash. - Washington State University researchers have developed ... sediment to power waste cleanup in rural areas. ... lead to an inexpensive and quick way to clean ... treatment plants while reducing pollution. , Professor Haluk ... College of Engineering and Architecture discuss the system in ...
(Date:9/18/2014)... a small, icy moon of Uranus, is one of ... solar system. Despite its relatively small size, Miranda appears ... resulted in the formation of at least three remarkable ... , These coronae are visible in Miranda,s southern ... across. Arden corona, the largest, has ridges and troughs ...
(Date:9/18/2014)... team of researchers from McGill University and the ... of polyethylene ,microbeads, Canadian Journal of Fisheries ... originate from cosmetics, household cleansers, or industrial cleansers, ... Owing to their small size and buoyancy, they ... Microplastics are a global contaminant in the world,s ...
Breaking Biology News(10 mins):Researchers develop unique waste cleanup for rural areas 2Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7Microplastic pollution discovered in St. Lawrence River sediments 2
... -- Many shark populations have plummeted in the past three ... fins, as an incidental catch of fisheries targeting other species, ... species. However, until now, a lack of data prevented scientists ... a large geographic scale. In a study published online ...
... Medical Center has been successful in attracting funding of ... funding was awarded in response to an application to ... (hemostaseologist) currently based in the USA, to the Center ... of the application was announced jointly by the Alexander ...
... plant disease normally found in subarctic climates has been identified ... far south as Herefordshire., Sclerotinia subarctica , a fungus ... been found in carrots and meadow buttercups in Perthshire by ... of Life Sciences at the University of Warwick. , It ...
Cached Biology News:Scientists provide first large-scale estimate of reef shark losses in the Pacific Ocean 2Mainz University Medical Center attracts funding of Alexander von Humboldt Professorship 2Mainz University Medical Center attracts funding of Alexander von Humboldt Professorship 3
(Date:9/18/2014)... -- About POCT POCT, also ... laboratory. It helps in making fast clinical decisions, ... POCT is gaining popularity due to the increasing ... diabetes, heart disease, and obesity. It is generally ... minimize errors during the diagnosis of patients. POCT ...
(Date:9/18/2014)... Bryan-College Station, Texas (PRWEB) September 18, 2014 ... University System Chancellor John Sharp, Texas A&M Health ... from the U.S. Department of Health and Human ... GSK today dedicated a national pandemic influenza vaccine ... will serve as an anchor for the Texas ...
(Date:9/18/2014)... 18, 2014 Research and Markets ... Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - ... offering. The global companion diagnostics market ... from 2014 to 2019. Factors such as rising need ... companion diagnostics by the pharmaceutical industry, support from regulatory ...
(Date:9/18/2014)... 2014 /PRNewswire/ - Oncothyreon Inc. (NASDAQ: ONTY ... but separate underwritten offerings of 10,000,000 shares of its ... $2.00 per share, for expected gross proceeds of $20 ... Preferred Stock at a price to the public of ... million. Each share of Series A Convertible Preferred Stock ...
Breaking Biology Technology:POCT Market in China 2014-2018 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 3Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3
... ... Advisory Board --, SAN DIEGO, July ... it has received regulatory approval to,begin a Phase 2a proof-of-concept clinical ... metabolic arthritis, is a,painful and debilitating disease caused by abnormally elevated ...
... July 9 ATS Medical, Inc.,(Nasdaq: ATSI ... and services, today announced it has obtained new ... of the ATS Open,Pivot(R) Mechanical Heart Valve., ... Open Pivot valve was implanted in Lausanne, Switzerland,on ...
... Genetics,Corporation (CellCyte) (OTC Bulletin Board: CCYG) has engaged ... financial advice and,services. CellCyte seeks to build shareholder ... will work with InCap to initiate a corporate,partnering ... expander and stem cell delivery technologies., "We ...
Cached Biology Technology:Ardea Biosciences' Advances RDEA806 Into Phase 2a Proof-of-Concept Study for Gout 2Ardea Biosciences' Advances RDEA806 Into Phase 2a Proof-of-Concept Study for Gout 3Ardea Biosciences' Advances RDEA806 Into Phase 2a Proof-of-Concept Study for Gout 4ATS Medical Confirms Excellent Durability of the ATS Open Pivot Mechanical Heart Valve 2CellCyte Genetics Retains InCap Group to Advise on Business Strategy and Financing 2CellCyte Genetics Retains InCap Group to Advise on Business Strategy and Financing 3CellCyte Genetics Retains InCap Group to Advise on Business Strategy and Financing 4