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Jefferson researchers provide genetic evidence that antioxidants can help treat cancer
Date:2/15/2011

t the Cav-1 protein, researchers found that oxidative stress in cancer associated fibroblasts leads to mitochondrial dysfunction in stromal fibroblasts. In this context, oxidative stress and the resulting autophagy (producton of recycled nutrients) in the tumor-microenvironment function as metabolic energy or "food" to "fuel" tumor growth.

The researchers report that the loss of Cav-1 increases mitochondrial oxidative stress in the tumor stroma, increasing both tumor mass and tumor volume by four-fold, without any increase in tumor angiogenesis.

"Antioxidants have been associated with cancer reducing effectsbeta carotene, for examplebut the mechanisms, the genetic evidence, has been lacking," Dr. Lisanti said. "This study provides the necessary genetic evidence that reducing oxidative stress in the body will decrease tumor growth."

Currently, anti-cancer drugs targeting oxidative stress are not used because is it commonly thought they will reduce the effectiveness of certain chemotherapies, which increase oxidative stress.

"We are not taking advantage of the available drugs that reduce oxidative stress and autophagy, including metformin, chloroquine and N-acetyl cysteine," Dr. Lisanti said. "Now that we have genetic proof that oxidative stress and resulting autophagy are important for driving tumor growth, we should re-consider using antioxidants and autophagy inhibitors as anti-cancer agents."

The diabetic drug metformin and chloroquine, which is used for the prevention and treatment of malaria, prevent a loss of Cav-1 in cancer associated fibroblasts (which is due to oxidative stress), functionally cutting off the fuel supply to cancer cells.

This research also has important implications for understanding the pathogenesis of triple negative and tamoxifen-resistance in ER-positive breast caner patients, as well as other epithelial cancers, such as prostate cancers.

"Undoubtedly, this new genetic
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Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

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Related biology news :

1. Jefferson researchers receive W.W. Smith Charitable Trust
2. Jefferson receives $3 million NIH grant to study molecular and genetic mechanisms in platelets
3. Jefferson scientists identify a new protein involved in longevity
4. US Department of State names UCR entomologist a Jefferson Science Fellow
5. Jefferson receives $1.7 million grant to study stem cells in intervertebral discs of the spine
6. Jefferson researcher awarded Landenberger Foundation grant for ALS research
7. Jefferson scientists discover a key protein regulator of inflammation and cell death
8. Jefferson Department of Surgery announces new pancreas tumor registry
9. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
10. Researchers working toward automating sedation in intensive care units
11. Boston University School of Medicine researchers receive NIMH brain awards
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