Navigation Links
Jefferson receives $3 million NIH grant to study molecular and genetic mechanisms in platelets
Date:8/27/2010

(PHILADELPHIA) Scientists at Jefferson Medical College have received a four-year, $3 million National Institutes of Health grant funded by the National Heart, Lung and Blood Institute to study variations of platelet function, specifically, the genetics of platelet gene expression. The study aims to find data that can be translated into novel therapeutic strategies and develop better predictors of cardiovascular disease.

"This study is at the leading-edge of platelet genetic research," said principal investigator Paul F. Bray, M.D., the Thomas Drake Martinez Cardeza Professor of Medicine and director, Division of Hematology in the Department of Medicine at Jefferson Medical College of Thomas Jefferson University. "We still have a limited understanding of the control mechanisms regulating platelet gene expression. Some patients have hyper-functioning platelets which can lead to strokes and heart attacks. On the other end of the spectrum there are some patients with bleeding disorders because their platelets don't clot well enough. Thus, we are talking about very common clinical problems affecting huge numbers of people. We are hoping to shed some light on how the balance gets tipped from health to disease via changes in these fascinating and complex blood cells."

The study will focus primarily on looking at platelet microRNA. MicroRNA's modify gene expression in all tissues, but little is known about how they function in platelets.

"We believe microRNAs serve as a rheostat for protein synthesis in platelets," said Bray. "There are thousands of different settings. People who suffer clotting problems may have different levels of platelet microRNAs than do healthy people. We are going to study platelet microRNAs from healthy individuals and determine how these levels correlate with platelet function. Once we know the situation in healthy subjects, we can assess the critical microRNA levels in patients with unhealthy pla
'/>"/>

Contact: Rick Cushman
richard.cushman@jefferson.edu
215-955-2240
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Jefferson Department of Surgery announces new pancreas tumor registry
3. Jefferson scientists discover a key protein regulator of inflammation and cell death
4. Jefferson researcher awarded Landenberger Foundation grant for ALS research
5. Jefferson receives $1.7 million grant to study stem cells in intervertebral discs of the spine
6. US Department of State names UCR entomologist a Jefferson Science Fellow
7. Jefferson scientists identify a new protein involved in longevity
8. Wistar Institute researcher receives New Innovator award from NIH
9. L-1 Identity Solutions Receives $5.9 Million Drivers License Contract Expansion from the State of Mississippi
10. Kount Receives Patent for Device Fingerprinting
11. American College of Medical Genetics receives $13.5M NIH contract
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... January 28, 2015 New Market ... And Segment Forecasts To 2020 has Been Added to ... market is expected to reach USD 5.10 billion by ... Research, Inc. IR cameras help identify the site of ... to witness surging demand in medical imaging applications. They ...
(Date:1/22/2015)... 22, 2015 Research and Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ) ... Global Market Overview" report to their offering. , ... ensure that an individual is who she/he is claiming to ... of a person,s unique physical characteristics, such as fingerprint, hand ...
(Date:1/22/2015)... 15, 2015  BellBrook Labs, a leader in high ... launch of a TR-FRET (time resolved Forster resonance ... Assay, a high throughput screening assay for glycosyltransferases ... allow for sensitive detection of hundreds of human ...
Breaking Biology News(10 mins):IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 3Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2
... microbes living in their roots, according to new research at ... carbon cycle that is vital to life on earth. ... to make sugar by combining water with carbon dioxide from ... scientists in the Universitys Department of Biology discovered that some ...
... a mucky Florida swamp have given scientists a window ... 15 million to 130 million years old. Scientists ... Natural History in Berlin made the landmark discovery that ... unwittingly swim into resin flowing down into the water ...
... Bats are the most vocal mammals other than ... outings could lead to better treatments for human speech ... of bats native to Central Texas fly overhead each ... frequencies too high for humans to hear. Texas ...
Cached Biology News:Hungry microbes share out the carbon in the roots of plants 2Scientists find how amber becomes death trap for watery creatures 2Scientists find how amber becomes death trap for watery creatures 3Researchers studying how singing bats communicate 2
(Date:3/2/2015)... Massachusetts (PRWEB) March 02, 2015 Outside ... services, today announced the addition of Debbie Casey as ... capabilities in the healthcare space. , Debbie ... most of which with Fresenius Medical Care North America ... leverage her extensive experience to work with Outside GC’s ...
(Date:2/27/2015)...  Pharmacyclics, Inc. (NASDAQ: PCYC ) ... newly developed Bruton,s tyrosine kinase (BTK) inhibitor for ... results of these preclinical evaluations have been communicated ... feedback received from the Agency is supportive of ... preclinical work is required to begin a Phase ...
(Date:2/27/2015)... Bionomics Limited (ASX:BNO, ADR:BMICY) is to present ... in patients with metastatic renal cancer at the ASCO ... . The data will be presented by Dr. ... Cancer Center in California in ... identifies Ferritin and IL-8 as two baseline biomarkers that ...
(Date:2/27/2015)...   PureTech , a science and technology R&D ... and technologies in the healthcare sector, announced today the ... Member of the Board of Directors of Sanofi, to ... been a pleasure to know Chris for many years ... working together more closely now," said Dr. Robert ...
Breaking Biology Technology:Outside GC Expands Healthcare Team 2Pharmacyclics Provides Clinical Update on BTK Inhibitor for Autoimmune Diseases 2Pharmacyclics Provides Clinical Update on BTK Inhibitor for Autoimmune Diseases 3New BNC105 Biomarker Data to be Presented at US Cancer Conference 2New BNC105 Biomarker Data to be Presented at US Cancer Conference 3New BNC105 Biomarker Data to be Presented at US Cancer Conference 4New BNC105 Biomarker Data to be Presented at US Cancer Conference 5Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 3Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 4
... YORK, March 7, 2011 Reportlinker.com announces ... available in its catalogue: ... Japan - Emerging Opportunities and Business Expansion ... http://www.reportlinker.com/p0365328/The-2011-Blood-Banking-Market-US-Europe-Japan---Emerging-Opportunities-and-Business-Expansion-Strategies-for-Suppliers.html During the next ...
... 2011 Champions Biotechnology, Inc. (OTC: CSBR), today announced its ... 2011. Fiscal 2011 Third Quarter Financial Highlights ... an increase of 278% compared to the third quarter of ... excluding stock based compensation of $796,000* Net ...
... the world of nanoparticles has now become a possibility, thanks ... UCSB research team has developed a new instrument capable of ... tens of nanometers. The study will be published on line ... the April print issue of the journal. "This ...
Cached Biology Technology:Reportlinker Adds The 2011 Blood Banking Market: US, Europe, Japan - Emerging Opportunities and Business Expansion Strategies for Suppliers 2Champions Biotechnology Reports Fiscal 2011 Third Quarter Financial Results 2Champions Biotechnology Reports Fiscal 2011 Third Quarter Financial Results 3Champions Biotechnology Reports Fiscal 2011 Third Quarter Financial Results 4Champions Biotechnology Reports Fiscal 2011 Third Quarter Financial Results 5Champions Biotechnology Reports Fiscal 2011 Third Quarter Financial Results 6New instrument keeps an 'eye' on nanoparticles 2
TRIS-EDTA based buffer prepared from RNase-free water suitable for storage and dilution of siRNA, pH 8, store at 4 C ...
Request Info...
Agarose-LE, 250 g. Suitable for soft agarose cloning. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1200 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
IC50: 3 ng/ml · Limit of detection: 0.9 ng/ml...
Biology Products: