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Jefferson receives $11.6M NIH grant to study novel mechanisms of heart failure
Date:5/20/2008

kinase inhibitor (including the very successful leukemia drug Gleevec), which interferes with a particular enzyme, can cause heart failure. But because the damage appears to be reversible, one theory says that the drugs, instead of damaging the heart cells, may actually hurt heart stem cells and prevent repair. Some early results in the laboratory with stem cell cultured with Gleevec seem to support the theory. Dr. Forces group will continue to test the tyrosine kinase inhibitor drugs to better understand how they affect cardiac stem cells.


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Contact: Rick Cushman
richard.cushman@jefferson.edu
215-955-2240
Thomas Jefferson University
Source:Eurekalert

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