Navigation Links
Jefferson receives $11.6M NIH grant to study novel mechanisms of heart failure
Date:5/20/2008

(PHILADELPHIA) Scientists at Jefferson Medical College have received a five-year, $11.6 million grant from the National Heart, Lung and Blood Institute to study molecular mechanisms of cardiac injury that lead to heart failure and potential repair processes that occur in the adult failing heart. This project aims to find data that can be translated into novel therapeutic strategies to improve the failing heart.

This study is unique in that were not only studying factors that contribute to heart failure but we are also looking for cellular and molecular mechanisms that promote repair for the damaged heart, said principal investigator Walter J. Koch, PhD., the W.W Smith Professor of Medicine and director of the Center for Translational Medicine in the Department of Medicine at Jefferson Medical College of Thomas Jefferson University. We will have four core facilities and four different labs working on this grant from a host of different angles. While much of the project will focus on the science of failure and repair, it is also clinically relevant in that we are working with stem cells and pharmaceutical drugs already being given to patients.

An advantage of this type of NIH Program Project Grant is that the four primary projects can be supported by core units. This grant supports four core areas: administrative, surgical, molecular and gene therapy and four main laboratories. In addition to Dr. Kochs leadership in these areas, leaders of these facilities are Andrea Eckhart, Ph.D., Patrick Most, M.D., Erhe Gao, M.D., Ph.D. and Joseph Rabinowitz, Ph.D., all faculty members in the Center for Translational Medicine.

Dr. Kochs group is studying how the enzyme GRK5, which plays a novel role in heart cell signaling and function, is involved in regulating heart cell gene transcription. Gene transcription is part of the two-step process that cells use to read a gene and produce a protein. According to Dr. Koch, abnormal increases in gen
'/>"/>

Contact: Rick Cushman
richard.cushman@jefferson.edu
215-955-2240
Thomas Jefferson University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
2. Jefferson urologists studying regenerated neo-bladder to help spinal cord injury patients
3. BIO-key(R) Receives $335,000 Contract Award From Baltimore Police
4. UCSB receives $3.2 million stem cell grant from state
5. Smithsonian scientist receives 2008 Medal for Excellence in tropical botany
6. Atmel Receives Frost & Sullivans Technology Innovation Award for FingerChip(R) Biometric Sensor
7. McMaster University engineering professor receives Humboldt Research Award
8. BIO-key(R) Receives New Mobile Data Contract Award From Indiana Police Agency
9. UMass Medical School researcher Victor Ambros receives Gairdner Award, Franklin Medal
10. Kansas state flower receives scientific attention
11. BIO-key(R) Receives New Mobile Data Contract Award From Indiana Police Agency
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... few years, Virginia Tech,s Wu Feng has built upon ... the "Computing in the Cloud" program, and synergistically complemented ... award from the Air Force on "big computing" for ... the National Institutes of Health on "big data" for ... "parallel computing" aspects from each grant, he was able ...
(Date:8/20/2014)... Carolina State University researchers have developed methods for electronically ... the electrical signals moths use to control those muscles. ... remotely-controlled moths, or "biobots," for use in emergency response. ... whether we can control the movement of moths for ... says Dr. Alper Bozkurt, an assistant professor of electrical ...
(Date:8/19/2014)... To improve students, chances of completing introductory biology ... Houston (UH) implemented a comprehensive student success program, ... failure. , Through a grant from the ... of Biology and Biochemistry embarked on a pilot ... for non-majors and "Introductory Biology" for science majors. ...
Breaking Biology News(10 mins):The internet was delivered to the masses; parallel computing is not far behind 2The internet was delivered to the masses; parallel computing is not far behind 3The internet was delivered to the masses; parallel computing is not far behind 4Research paves way for development of cyborg moth 'biobots' 2University of Houson program earns kudos for improving grades, retaining students 2University of Houson program earns kudos for improving grades, retaining students 3
... Management ... Solutions, ... a leader in finger-based biometric,identification and wireless public safety, announced today ... a patent for the,company,s "Biometric Identification Network Security" method., This ...
... time thinking about beer, but a group of Rice ... They,re using genetic engineering to create beer that contains ... reduce cancer and heart disease in lab animals. ... Engineered Machine (iGEM) competition Nov. 8-9 in Cambridge, Mass. ...
... and Infectious Diseases (NAID), one of the National Institutes ... of Washington (UW) to use systems biology approaches to ... response networks that are induced or altered during the ... research program will be led by Dr. Michael Katze, ...
Cached Biology News:BIO-key(R) Granted Additional Patent for Biometric Security Solution 2BIO-key(R) Granted Additional Patent for Biometric Security Solution 3Better beer: College team creating anticancer brew 2Better beer: College team creating anticancer brew 3NIAID funds studies of how SARS and bird flu evade antiviral responses 2
(Date:8/18/2014)... Fla. , Aug. 18, 2014 TNI ... biotechnology company pioneering the manufacturing and marketing of innovative ... that the Company is providing a second notice of ... In making the announcement, Noreen Griffin , ... you in advance for your participation in the Annual ...
(Date:8/18/2014)... 18, 2014 China is increasingly ... the clinical research industry. Clinicaltrial.gov statistics highlight the ... its aging population; a high increase in infectious ... densely populated pool of patients and a track ... positive points, China also presents challenges for the ...
(Date:8/16/2014)... 2014 Firms in the ... and advisory services to businesses, government bodies and ... services are highly diverse as operators assist a ... from geological and geophysical consulting services to risk ... past five years, the recovery of the Canadian ...
(Date:8/16/2014)... have found a way to make atomic-force microscope probes ... as small as the weight of an individual virus. ... National University (ANU), hinges on using laser beams to ... , "The level of sensitivity achieved after cooling is ... a large virus that is 100 billion times lighter ...
Breaking Biology Technology:TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 2TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 3TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 4China – Land of Opportunities & Challenges for the Clinical Research Industry, New Webinar Hosted by Xtalks 2Scientific and Economic Consulting in Canada Industry Market Research Report Now Available from IBISWorld 2Scientific and Economic Consulting in Canada Industry Market Research Report Now Available from IBISWorld 3Laser makes microscopes way cooler 2
... 17, 2010 Shire plc (LSE: SHP,NASDAQ: SHPGY ), the ... Anne Minto OBE, have been appointed to the,Shire Board of Directors with ... ... Human,Genetics at the Life Sciences Institute, University of Michigan ; an,Investigator ...
... June 17, 2010 An independent study has revealed,that Irish ... and consistent than a leading group of,international hypertension experts. , ... Conducted by the ... numerous blood pressure readings taken over a,24-hour period (known as ,Ambulatory Blood ...
... 17 OncoMed Pharmaceuticals, Inc. and Bayer Schering Pharma AG, ... develop and commercialize novel anti-cancer stem cell therapeutics targeting the Wnt ... believed to play a significant role in the establishment, metastasis and ... , , ...
Cached Biology Technology:Shire plc Appoints Two New Board Directors 2Shire plc Appoints Two New Board Directors 3Shire plc Appoints Two New Board Directors 4Independent Study Reveals dabl System Leads the way in Accurate Cardiovascular Diagnosis 2Independent Study Reveals dabl System Leads the way in Accurate Cardiovascular Diagnosis 3OncoMed Pharmaceuticals and Bayer Schering Pharma Announce Strategic Alliance to Develop Anti-Cancer Stem Cell Therapeutics 2OncoMed Pharmaceuticals and Bayer Schering Pharma Announce Strategic Alliance to Develop Anti-Cancer Stem Cell Therapeutics 3OncoMed Pharmaceuticals and Bayer Schering Pharma Announce Strategic Alliance to Develop Anti-Cancer Stem Cell Therapeutics 4OncoMed Pharmaceuticals and Bayer Schering Pharma Announce Strategic Alliance to Develop Anti-Cancer Stem Cell Therapeutics 5
... easy transformation of the budding yeast, Saccharoyces ... simply by mixing a plasmid DNA and ... No complicated steps, such as centrifugation or ... particularly well suited for high-throughput transformation of ...
... The STag Purification Kits enable rapid analytical ... fusion proteins produced from appropriate vectors. Sufficient ... to 1 mg target protein under native ... with S-protein Agarose, which specifically retains STag ...
Request Info...
... Epitope: aa 16-25 of human GSK3 alpha. ... Storage: Store vial at -20 C prior to opening. ... aliquot contents and freeze at -20 C or below. ... Other Sub-Family: not assigned-Other ...
Biology Products: