Navigation Links
Jefferson receives $1.7 million grant to study stem cells in intervertebral discs of the spine
Date:6/4/2009

(PHILADELPHIA) Scientists at Jefferson Medical College have received a five-year, $1.7 million National Institutes of Health grant funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases to study mechanisms regulating stem cell self-renewal and differentiation with the aim of regenerating diseased and painful intervertebral discs. A previous study by the same group showed that stem cells exist in both animal and human intervertebral discs. This grant will enable the researchers to continue studying the disc cells and determine factors which govern their activities in health and disease.

"Disc degeneration and the associated back pain that goes with it costs the U.S. healthcare industry approximately $100 billion annually," said Irving M. Shapiro, Ph.D., associate director of Orthopedic Research and the director of the Cell and Tissue Engineering Graduate Program at Jefferson Medical College of Thomas Jefferson

University. "As a major cause of lost productivity worldwide it is critical that we develop a treatment that will regenerate intervertebral disc structure and function."

A variety of factors contribute to the degeneration of the intervertebral disc including age, genetics and biomechanical factors. Several surgical procedures are available to pacify the pain associated with the degenerative disc, but the most common procedures often only provide symptomatic relief. No current therapy can completely restore the function of a degenerated disc nor prevent its further deterioration. Historically, investigations of the intervertebral disc have been limited in scope, leading to a lack of understanding of the biology and function of both healthy and diseased tissues.

"Researchers have tried repairing the discs by injecting them with agents that are thought to have beneficial effects on cell function," said Makarand Risbud, Ph.D, associate professor of Orthopedic Surgery at Jefferson Medical College
'/>"/>

Contact: Rick Cushman
richard.cushman@jefferson.edu
215-955-2240
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Jefferson researcher awarded Landenberger Foundation grant for ALS research
2. Jefferson scientists discover a key protein regulator of inflammation and cell death
3. Jefferson Department of Surgery announces new pancreas tumor registry
4. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
5. Jefferson receives $11.6M NIH grant to study novel mechanisms of heart failure
6. Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
7. Jefferson urologists studying regenerated neo-bladder to help spinal cord injury patients
8. Tulane receives grant to study limb regeneration
9. Springer Series editor John Smol receives two prestigious biology awards
10. URI receives $18 million grant to strengthen biomedical research capacity in Rhode Island
11. Vitamin D expert receives Linus Pauling Prize for Health Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/12/2015)... MINNETONKA, Minn. , Aug. 12, 2015   ... that supports the entire spectrum of clinical research, is ... ™ , the company,s comprehensive SaaS-based eClinical technology platform, ... growth during the first two quarters of 2015.   ... and second largest quarters measured by contract value sold ...
(Date:8/12/2015)... JOSE, Calif. , Aug. 12, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that ... recently announced Match-in-Sensor solution, have officially been named ... Alliance. As part of the certification, Synaptics, Natural ... FIDO 1.0 Universal Authentication Framework (UAF) standard and ...
(Date:8/10/2015)... LONDON , August 10, 2015 ... visiongain offers comprehensive analysis of the global border ... will generate revenues of $16.4bn in 2015. Now: ... This is an example of the business critical issue you ... to read visiongain ,s objective analysis of how this ...
Breaking Biology News(10 mins):MedNet Solutions Experiences Explosive Corporate Growth 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 4Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 5Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 7Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 8Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 9
... New Rochelle, NY, June 28, 2013 Mary Ann Liebert, ... Printing and Additive Manufacturing , a highly innovative, peer-reviewed ... issue will publish in the fall of 2013, and ... the Director of Cornell University,s Creative Machines Lab at ...
... The world,s food supply got a little more plentiful thanks ... plant pathology at Kansas State University, and his colleague, Jorge ... that identified a gene that gives wheat plants resistance to ... rust pathogen -- called Ug99 -- that was first discovered ...
... 28 2013) A study carried out in India examining ... marrow stem cells in patients with type 2 diabetes ... compared to a control group of TD2M patients who ... The study appears as an early e-publication for the ...
Cached Biology News:Resistance gene found against Ug99 wheat stem rust pathogen 2Resistance gene found against Ug99 wheat stem rust pathogen 3Type 2 diabetes patients transplanted with own bone marrow stem cells reduces insulin use 2
(Date:8/28/2015)... , Aug. 28, 2015 /PRNewswire/ - RepliCel Life ... regenerative medicine company focused on the development of ... the quarter ended June 30, 2015, corporate highlights, ... management report are available at www.sedar.com ,  ... "RepliCel expects to launch its ...
(Date:8/28/2015)... , ... August 28, 2015 , ... Since the initial launch of FireflySci Inc. (FFS) ... humor and excellent customer service. Images such as the Fonz in a lab coat ... some flavor to the humdrum spectroscopy field. , FireflySci is proud to be ...
(Date:8/27/2015)... VA (PRWEB) , ... August 27, 2015 , ... ... contractors solve complex business problems, is pleased to announce their ranking as one of ... annual ranking of the fastest-growing private companies across the nation. , “It is truly ...
(Date:8/27/2015)... 27, 2015 /PRNewswire/ - Portage Biotech Inc. ("Portage") ... Biohaven Pharmaceutical Holding Company Limited (Biohaven), announced today ... study of BHV-0223, a glutamate modulating agent. Biohaven ... and recently obtained clearance from the U.S. Food ... testing. Portage holds 54% equity interest in Biohaven, ...
Breaking Biology Technology:RepliCel Reports Second Quarter 2015 Financial Results 2RepliCel Reports Second Quarter 2015 Financial Results 3RepliCel Reports Second Quarter 2015 Financial Results 4RepliCel Reports Second Quarter 2015 Financial Results 5Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4
... ... Issues of Food and Drug Safety , ... Rockville, Md. (Vocus) September 29, 2009 -- Counterfeit and adulterated food and drugs ... Annual Scientific Meeting (ASM) hosted by the U.S. Pharmacopeial (USP) Convention. Held in Toronto, Canada, ...
... on science especially emerging technologies such as nanotechnology ... science policy released today argues. The group of leading ... that current governance activities are limiting public debate and ... DEEPEN report comes in the wake of a move ...
... /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. (TSX: ONC, NASDAQ: ... by Prof. Hardev Pandha of the Royal Surrey County ... online version of Clinical Cancer Research. The paper is ... in Murine Malignant Melanoma." , The research demonstrated that ...
Cached Biology Technology:Global Public Health the Focus of Scientific Conference 2Global Public Health the Focus of Scientific Conference 3Public must be involved in nanotech policy debate demands groundbreaking 2Oncolytics Biotech(R) Inc. Announces Reovirus and Cisplatin Research Supports U.S. Phase 2 Metastatic Melanoma Trial 2