Navigation Links
Japanese researchers report on liver transplantation studies using animal and iPS cells
Date:10/18/2010

Tampa, Fla. (October 18, 2010) Two research teams from the Okayama University Graduate School of Medicine (Okayama, Japan) have reported breakthrough studies in liver cell transplantation. One team found that the technical breakthrough in creating induced pluripotent stem cells (iPS) from mouse somatic cells (nonsex cells) in vitro had "implications for overcoming immunological rejection." Whereas a second team using liver cell xenotransplantation - transplanting cells of one species into another (in this case transplanting pig liver cells into mice) - found that transplanted liver cells from widely divergent species can function to correct acute liver failure and prolong survival.

Their studies, published in the current issue of Cell Transplantation (19:6/7), are freely available on-line at http://www.ingentaconnect.com/content/cog/ct/

Somatic cells differentiate into hepatocyte-like cells

A research team at the Okayama University Graduate School of Medicine, working with colleagues at the University of Pittsburgh School of Medicine found that mouse induced pluripotent stem (iPS) cells are pluripotent (able to differentiate into many varieties of stem cells) and able to proliferate in vitro without limits and could be cultured to become hepatocyte-like cells.

According to the researchers, a major limitation for cell-based therapies to treat liver diseases is the shortage of cell donors. Rejection is still an issue and chronic immunosuppression is required for allotransplantation (cells from nonidentical donors), making patient-derived cells, especially somatic cells (non-sex cells) attractive for transplantation.

"The ability to make iPS cells from somatic cells has implications for overcoming both immunological rejection and ethical issues associated with embryonic stem cells," said corresponding author Dr. Masaya Iwamuro. "Our study will be an important step in generating hepatocytes from human iPS cells as a new source for liver-targeted cell therapies."

The researchers found that the transplanted hepatocyte-like cells they produced from the mouse iPS cells increased the production of albumin and were also able to metabolize ammonia, which are characteristics of functional hepatocytes.

"In the future, studies will generate new therapies that include the transplantation of iPS cell-derived hepatocytes without immunological barrier, in vitro determination of toxicity, and the development of personalized health care by evaluating drugs for efficacy and toxicity on patient-specific hepatocytes," concluded Dr. Iwamuro.


'/>"/>

Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Springer and Japanese Society of Biorheology to work together
2. Geraniums could help control devastating Japanese beetle
3. Japanese gourmet mushroom found in Sweden
4. UCLA, Japanese company to collaborate on specialized nano-imaging instrumentation
5. NC State researchers get to root of parasite genome
6. Researchers find animal with ability to survive climate change
7. Researchers find an essential gene for forming ears of corn
8. Researchers note differences between people and animals on calorie restriction
9. Researchers study acoustic communication in deep-sea fish
10. Researchers discover that growing up too fast may mean dying young in honey bees
11. Researchers study how pistachios may improve heart health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
(Date:4/28/2016)... and BANGALORE, India , April 28, 2016 ... a product subsidiary of Infosys (NYSE: INFY ), ... a global partnership that will provide end customers ... mobile banking and payment services.      (Logo: ... innovation area for financial services, but it also plays a ...
(Date:4/15/2016)...  A new partnership announced today will help ... in a fraction of the time it takes ... life insurance policies to consumers without requiring inconvenient ... Diagnostics, rapid testing (A1C, Cotinine and HIV) and ... weight, pulse, BMI, and activity data) available at ...
Breaking Biology News(10 mins):
(Date:5/20/2016)... ... May 20, 2016 , ... The leading Regenerative Veterinary ... most experienced veterinary clients have treated over 100 of their own patients with the ... provide the highest level of care for their patients. , The veterinarians are ...
(Date:5/19/2016)... ... May 19, 2016 , ... Anton Paar USA, located in Ashland, Virginia is ... complete. The new structure adds a third office building to the current facilities. ... 2.4 acres of land, along with office space adjacent to the previous main building. ...
(Date:5/19/2016)... 2016 Regen BioPharma, ... RGBPP) announced today initiation of a preclinical development ... based cancer immunotherapeutic product leveraging its NR2F6 immunological ... a generation of cord blood derived killer cells ...  The product in development will be a "universal ...
(Date:5/18/2016)... 18, 2016 The Biotech industry continues ... mean that there are no opportunities ahead. Today, ActiveWallSt.com has ... THLD ), Seattle Genetics Inc. (NASDAQ: ... Ophthotech Corp. (NASDAQ: OPHT ). Sign up now ... http://www.activewallst.com/ Threshold Pharmaceuticals Inc.,s shares ...
Breaking Biology Technology: