Navigation Links
Jan-Åke Gustafsson leads team with $5.2M for prostate cancer research
Date:4/1/2011

HOUSTON, April 1, 2011 A pair of University of Houston (UH) researchers and their colleagues will begin work to develop new methods for treating the most severe form of prostate cancer thanks to $5.2 million in grants recently awarded by the Cancer Prevention and Research Institute of Texas (CPRIT).

Renowned hormone researcher Dr. Jan-ke Gustafsson, Robert A. Welch Professor in UH's biology and biochemistry department and director of the Center for Nuclear Receptors and Cell Signaling (CNRCS), will oversee the multi-investigator award. The work will be an interdisciplinary collaboration with researchers from the CNRCS at UH, The Methodist Hospital Research Institute (TMHRI) and the University of Texas at El Paso (UTEP).

As the founding researchers of CNRCS, Gustafsson and UH biology and biochemistry professor Margaret Warner will collaborate with Paul Webb of TMHRI and Marc Cox of UTEP to explore new treatments for prostate cancer. Gustafsson, who discovered a previously unknown estrogen receptor during the mid-1990s, is internationally recognized as a leading authority on hormone receptors and will lead the group in the discovery of innovative approaches to slowing the growth of early-stage cancers and combating late-stage cancers.

"More than 200,000 new cases of prostate cancer are diagnosed annually, affecting one in six men. In approximately one-third of diagnosed cases, the disease spreads and invades other tissues to become life-threatening," Gustafsson said. "Through this grant, we will be able to open the door for new and better therapies. Our early efforts have yielded promising results, and we look forward to building on our previous successes."

Prostate cancer grows and survives on male hormones called androgens, and current treatments target these naturally occurring hormones. This can result in negative and harmful side effects. In the most severe and recurrent forms, the cancer can become resistant to this therapy, at which point treatment options are extremely limited.

Armed with decades of experience in hormone research, Gustafsson and Warner will test plant-derived and synthetic chemicals resembling hormones to prevent and combat prostate cancer. The team also plans to develop drugs that target new areas of the androgen signaling system and work differently from existing therapies. Their collaboration with Webb and Cox will allow the team to expedite testing the feasibility of the new methods of treatment.

"This important award is an indication of UH's continuing commitment to research excellence and reflects the emphasis we place on finding real solutions to health-related problems," said UH President Renu Khator.

These grants, announced March 24, are part of $116 million awarded by CPRIT to 22 cancer research and commercialization projects at 16 Texas-based institutions and private companies. This is the second time the CNRCS has benefitted from CPRIT funding. Anders Strom, another researcher within the center, received funding from the institute last year for a collaborative project with TMHRI to develop new therapies for treating secondary tumors that may result from current breast cancer treatments.

In 2007, the state dedicated $3 billion to establish CPRIT and invest in groundbreaking cancer research and prevention programs in Texas. The institute focuses on expediting the innovation and commercialization of research, increasing the potential for breakthroughs and enhancing access to evidence-based prevention programs and services.


'/>"/>

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

Related biology news :

1. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
2. How neuronal activity leads to Alzheimers protein cleavage
3. Exposing chicks to maternal stress leads to long-term reproductive success
4. TECNALIA leads five projects within the VII Framework Program
5. Personalized medicine: Innovative online journal leads the way
6. Mayo Clinic research on tamoxifen leads to recommendation for CYP2D6 gene test
7. Study of placenta unexpectedly leads to cancer gene
8. Game of two halves leads to brain asymmetry
9. Transportation fuels of the future: Nottingham leads the way
10. Concordia University leads academic team for national Cellulosic Biofuels Network
11. Elephant shark genome sequence leads to discovery of color perception in deep-sea fish
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Jan-Åke Gustafsson leads team with $5.2M for prostate cancer research
(Date:2/8/2017)... YORK , Feb. 7, 2017 Report Highlights ... The ... should reach $11.4 billion by 2021, growing at a compound ... Includes - An overview of the global markets for synthetic ... 2015, estimates for 2016, and projections of compound annual growth ...
(Date:2/8/2017)... Feb. 7, 2017 Report Highlights ... 2021 from $8.3 billion in 2016 at a compound ... 2021. Report Includes - An overview of the ... trends, with data from 2015 and 2016, and projections ... Segmentation of the market on the basis of product ...
(Date:2/7/2017)... Feb. 7, 2017 Zimmer Biomet Holdings, Inc. ... healthcare, will present at the LEERINK Partners 6th Annual ... Hotel on Wednesday, February 15, 2017 at 10 a.m. ... the presentation can be accessed at http://wsw.com/webcast/leerink28/zbh .  ... conference via Zimmer Biomet,s Investor Relations website at ...
Breaking Biology News(10 mins):
(Date:2/20/2017)... YORK , Feb. 20, 2017 This report ... by the following Product Types: Xylanase, Amylase, Cellulase, and Others. ... Canada , Japan , ... Latin America , and Rest of World. ... Annual estimates and forecasts are provided for the period ...
(Date:2/20/2017)... ... February 20, 2017 , ... Cancer diagnostics and ... Oncology™” (Crosswalk), a unique precision medicine knowledge visualization and decision support platform. ... Inspirata’s diagnostic cockpit and is downloadable as an app for any mobile device ...
(Date:2/20/2017)... ... February 20, 2017 , ... ... chest wall collapses in pre-term infants with respiratory distress, and assist surgeons ... $600,000 in funding through the ninth round of the University City Science ...
(Date:2/20/2017)... Feb. 20, 2017  Former NFL players who had repeated ... later in life, according to a preliminary study released today ... 69th Annual Meeting in Boston , April ... complex movements where the muscles and nerves work together, like ... ...
Breaking Biology Technology: