Navigation Links
Jamming in tumors
Date:1/29/2014

This news release is available in German.

Just like healthy cells, tumour cells need nutrients and oxygen in order to survive. For this reason, a tumour of a certain size has to ensure that it is connected to the blood circulation. In doing this, it is supported by cells of the innate immune system, the neutrophil granulocytes or brief neutrophils, which are supposed to protect the body against pathogens.

Neutrophils normally circulate in the blood untilattracted by so-called chemokinesthey enter the tissue where they ingest and destroy intruding pathogens. In addition, these cells are able to trigger the formation of blood vessels. Presumably, this is how they help to repair tissue which has been destroyed by inflammation. However, neutrophils are also able to enter cancer tissue and contribute to its connection to the blood supply. This is probably the reason why detection of numerous neutrophils in a tumour is a sign of unfavourable patient prognosis.

Interferon-beta (IFN-beta) is used as a treatment for some tumours such as melanomas and leukaemia. Scientists at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany, had shown recently that this messenger molecule can interfere with cancer growth by inhibiting the formation of new blood vessels. However, the way it does so remained a puzzle.

Now, researchers have succeeded in revealing the effect of IFN-beta on migration of pro-tumour neutrophils. "We wanted to understand why IFN-beta prevents the neutrophils from entering the tumour," says Dr Jadwiga Jablonska-Koch, scientist in the "Molecular Immunology" department at the HZI. "This would be the way for physicians to improve existing therapies and choose appropriate treatment for the individual patient."

To this end, the
'/>"/>

Contact: Birgit Manno
presse@helmholtz-hzi.de
49-053-161-810
Helmholtz Centre for Infection Research
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Multiple myeloma study uncovers genetic diversity within tumors
2. Stopping tumors in their path
3. Deep sequencing of breast cancer tumors to predict clinical outcomes after single dose of therapy
4. Gene promotes 1 in 100 of tumors
5. A hallmark for the development of testicular tumors found in the aberrant regulation of small non-coding RNA
6. Copper intake makes tumors breathe
7. Microbes in the gut help determine risk of tumors
8. Researchers Able to Identify that Benign Tumors from Use of Oral Contraceptive Have a Greater Chance of Becoming Malignant
9. Stealth nanoparticles lower drug-resistant tumors defenses
10. Why tumors become drug-resistant
11. RI Hospital: Absence of specific enzyme in cartilage can lead to benign tumors in mice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Jamming in tumors
(Date:6/17/2015)... JOSE, Calif. , June 17, 2015 /PRNewswire/ ... in human interface solutions, today announced that Xiaomi, ... adopted the Synaptics ® ClearPad ® ... of display driver integrated circuits (DDICs) for its ... Pro. By leveraging ClearPad for full in-cell display ...
(Date:6/16/2015)... 2015 Fingerprint Cards (FPC) raises the ... will amount to at least 340 MSEK to that it ... increase in market growth and orders received the revenue guidance ... revenue for 2015 will exceed 1,500 MSEK to an updated ... MSEK. Due to receipt of orders of touch ...
(Date:6/11/2015)... Va. , June 11, 2015 ... technology, announced today that its IdentityX Mobile Authentication ... (Fast IDentity Online) Alliance is an industry consortium ... open standards for simpler, stronger authentication.  In order ... must pass a rigorous series of tests that ...
Breaking Biology News(10 mins):Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3Daon's IdentityX Mobile Authentication Platform One of First Products to be Certified by FIDO Alliance 2
... the UK have presented evidence that vigorous physical activity ... results were presented at the World Congress on Osteoporosis ... six-year olds participated in the study. Using advanced scanning ... structure of the femoral neck (hip) and thigh bone. ...
... Hinxton, 10 May 2010 The European Nucleotide Archive ... to become Europe,s primary access point to globally comprehensive ... available from the European Bioinformatics Institute (EMBL-EBI), a part ... DNA sequencing has led to previously unimaginable amounts of ...
... sources of renewable energy, but which ones should industry ... new study involving researchers from North Carolina State University ... burned. Their data and new computer models pave the ... maximize energy efficiency while minimizing environmental and human health ...
Cached Biology News:Enabling easy access to DNA sequence information 2Study paves way for new biofuels models, technologies 2
(Date:6/29/2015)... ... June 30, 2015 , ... This cutting edge standard making is ... Featuring 12 distinct peaks, the WAV-8 is the world’s first cuvette-shaped, solid-state filter that ... into the NIR range. Previous spectrophotometer calibration standards, such as those made from didymium ...
(Date:6/29/2015)... WASHINGTON , June 29, 2015  AACC, ... to better health through laboratory medicine, is pleased ... journal, Clinical Chemistry , has increased to ... Reports. This increase places Clinical Chemistry ... and reflects the significant influence of the research ...
(Date:6/29/2015)... , June 29, 2015   Veracyte, Inc . ... the field of molecular cytology, today announced that it ... prestigious Top Workplaces list for the second year in ... based solely on an annual survey of Bay Area-company ... that the degree to which Veracyte values our employees ...
(Date:6/26/2015)... /PRNewswire/ - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ... listed in the management information circular dated June 1, ... Meeting of Shareholders, held earlier today, June 26 ... 5 nominees proposed by management were elected as ... Company,s next Annual Meeting of Shareholders or until ...
Breaking Biology Technology:FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 2FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 3AACC's Journal, Clinical Chemistry, Continues to Have Significant Impact on Medical Testing, Healthcare 2AACC's Journal, Clinical Chemistry, Continues to Have Significant Impact on Medical Testing, Healthcare 3Veracyte Named a 2015 "Top Workplace" in the San Francisco Bay Area 2Veracyte Named a 2015 "Top Workplace" in the San Francisco Bay Area 3iCo Therapeutics Announces Voting & Election Results from Annual Meeting of Shareholders 2iCo Therapeutics Announces Voting & Election Results from Annual Meeting of Shareholders 3
... Calif., Nov. 20 AMDL, Inc. (Amex:,ADL), ... China, through its,wholly owned subsidiary Jade Pharmaceutical ... in the development, manufacture and,marketing of proprietary ... has launched significant new expansion plans to ...
... into an old idea, MIT Institute Professor Mildred ... for controlling temperatures that could lead to substantial ... photovoltaic cells and electronic devices. , Novel ... consumer product: a simple, efficient way of cooling ...
... (Nasdaq: EXEL ) announced today that that it will hold ... a.m. ET /,7:00 a.m. PT to 2:00 p.m. ET / 11:00 ... and may be accessed in the Event Calendar,page under Investors at ... available until 9:00 p.m. PT / 12:00,a.m. ET on January 4, ...
Cached Biology Technology:AMDL Launches New JPGreen Business Strategy 2MIT: Thermoelectric materials are 1 key to energy savings 2MIT: Thermoelectric materials are 1 key to energy savings 3
... Proliferation Kit, For 100 slides. Immunocytochemistry.Sample ... in vitro tissue labeling.Recommended cell number: ... (labeling 1-2 hours).Store at 2-8 C ... Category: Drug Screening & Cellular Assays, ...
Dysadherin 2 (L-15)...
p-Bcl-2 (Thr 74)...
Trx-2 (71G4)...
Biology Products: