Navigation Links
James Briscoe awarded 2008 EMBO Gold Medal
Date:7/10/2008

molecule called Sonic Hedgehog, or Shh, that is secreted from a particular region in the spinal cord."

Briscoe and his group discovered a novel mechanism that allows cells to integrate the time of exposure and the concentration of the morphogen Shh to subsequently mount a graded response. In other words, different concentrations of the morphogen activate a signal within the receiving cell for different periods of times. Cells in turn respond to different durations of the signal by activating different genes and therefore becoming different types of nerve cells.

"The discovery that concentration is effectively converted into time is a major shift in our understanding of how a graded signal acts to regulate genes," stated David Wilkinson, Head of Genetics and Development at NIMR, in his nomination of Briscoe for the EMBO Gold Medal.

James Briscoe's contribution to the understanding of how cell identity is specified in a given spatial setting has established a new paradigm that may also apply in many other contexts. In addition to Shh, a number of other secreted molecules members of different protein families have also been implicated in acting as morphogens to pattern other tissues. "It is possible that other morphogens could use a similar mechanism to control cells, for example early in embryo development during gastrulation," explains the Gold Medal winner.

"James's discoveries have revealed general principles that may apply to many other contexts in which graded signals and downstream transcription factors control cell identity," confirmed David Wilkinson.

Robb Krumlauf, former Head of Division at NIMR who helped to recruit Briscoe to the institute, points out his outstanding qualities at the bench: "At NIMR James rapidly established an independent and creative line of research in his own group. His work is highly rigorous, hits the heart of a problem, and continues to be timely and of wide general interest."


'/>"/>

Contact: Suzanne Beveridge
communications@embo.org
49-622-188-91108
European Molecular Biology Organization
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. NASA scientist James Hansen to speak at July 11 conference on Rejuvenating Public Sector Science
2. 12 McGill researchers awarded Canada Research Chairs
3. Anthony S. Fauci awarded Lasker Award for Public Service
4. ETH Zurich professor Ari Helenius awarded Benoist Prize
5. Nanobiosym awarded $2 million DTRA contract
6. Mustafa alAbsi Ph.D. and national team awarded major NIH grant
7. Parus Interactive Awarded Patent for Speech-Activated Remote System Management
8. $2.7 million awarded for metastatic colon cancer research
9. UCR researchers awarded nearly $1.7M to develop improved cowpea varieties
10. BIO-key(R) and Tiger IT Awarded a Follow-on Contract for Nationwide Voter / Citizen Registration in Bangladesh
11. University awarded £5M to investigate how cells communicate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... map social connections in prairie dogs have uncovered ... on prairie dog communities that may help limit ... conservation efforts. The work was done by researchers ... Evolutionary Synthesis Center (NESCent). , "Prairie dogs are ... says Dr. Jennifer Verdolin, lead author of a ...
(Date:7/27/2014)... of mayfly in the southern Western Ghats, a mountain range ... the first time that any mayfly belonging to the genus ... The new species, called Labiobaetis soldani , "is named ... to the understanding of the Ephemeroptera of Palaearctic and Oriental ... the new mayfly in the Journal of Insect Science ...
(Date:7/27/2014)... over 18,000 patients, scientists have identified more than ... disease, including six that had not been previously ... , was partially funded by the National Institutes ... in NIH laboratories. , "Unraveling the genetic underpinnings ... mechanisms involved in this complex disease, and hopefully, ...
Breaking Biology News(10 mins):Social network research may boost prairie dog conservation efforts 2NIH scientists find 6 new genetic risk factors for Parkinson's 2
... brought honey bees (Apis mellifera) to the Americas, Mayan bee ... native to tropical forests. Now, colleagues from the Colegio de ... Tropical Research Institute (STRI) warn of the imminent demise of ... cultural change and habitat loss. , "In our initial surveys ...
... shark skin could help ships sailing smoothly. The growth ... is a major cause of increased energy costs in ... that prevents this so called 'bio-fouling'. , Ralph Liedert ... presenting his work on the application of artificial shark ...
... One teenager likes to snowboard off a cliff. Another ... trading places. Why these differences exist is a mystery, ... possible genetic explanation behind risk-seeking behavior. , Scientists ... a specific neurodevelopmental gene, called neuroD2, is related to ...
Cached Biology News:Mayan stingless bee keeping: Going, going, gone? 2Study identifies gene in mice that may control risk-taking behavior in humans 2Study identifies gene in mice that may control risk-taking behavior in humans 3
(Date:7/28/2014)... MD (PRWEB) July 28, 2014 ... personalized medicine, will be exhibiting data and research conducted ... International Spine Intervention Society’s (ISIS) 22nd Annual ... 3rd, at the Hyatt Regency, in Orlando, Florida. ... knowledge and clinical competence of physicians who care for ...
(Date:7/28/2014)... DALLAS , July 28, 2014 /PRNewswire/ ... research report  "Microbial Identification Market by Products (Consumables, Instruments, ... & Beverages), End User (Detection, Characterization) - ... global Microbial Identification Market is estimated at ... to reach $1,194.1 Million by 2019, growing ...
(Date:7/28/2014)... --  Propeller Health , the FDA-cleared digital health solution ... Brad Towle as Senior Vice President, Business and ... company,s sales growth, customer acquisition and program expansion. ... past role in the development of accountable care organizations, ... time in the industry," said David Van Sickle ...
(Date:7/28/2014)... 28, 2014 The global market for ... 2020, according to a new study by Grand View ... demand for effective vaccines and drugs in an attempt ... needs is expected to drive market demand over the ... agricultural productivity via the use of genetically engineered seeds ...
Breaking Biology Technology:Proove Biosciences Exhibits Industry Leading Data and Research at International Spine Intervention Society’s 22nd Annual Scientific Meeting 2Microbial Identification Market worth $1,194.1 Million by 2019 2Microbial Identification Market worth $1,194.1 Million by 2019 3Propeller Health Hires Brad Towle as Senior Vice President of Business and Client Development 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 3Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 4
... day that a research scientist and university professor gets to see ... few months, Richard W. Siegel will get to watch his name ... a new title that seems light years away from laboratory benches ... MAX," has been a three-year labor of love for Siegel. From ...
... IN KEY GLOBAL MARKETS, RANCHO CORDOVA, Calif., ... a leading supplier of innovative products and,services that ... it has signed,a distribution agreement with Celling Technologies ... stem cells from bone,marrow. The distribution rights are ...
... Sept. 9 For the second consecutive,year, MedNet ... study management systems, has been recognized by,Inc. magazine ... private,organizations. With consistently strong growth over the past ... in the Twin Cities,metro area, and fifth among ...
Cached Biology Technology:Professor-turned-producer learns the movie biz 2Professor-turned-producer learns the movie biz 3Professor-turned-producer learns the movie biz 4Professor-turned-producer learns the movie biz 5ThermoGenesis Announces Distribution Agreement for Bone Marrow Stem Cell Device 2ThermoGenesis Announces Distribution Agreement for Bone Marrow Stem Cell Device 3ThermoGenesis Announces Distribution Agreement for Bone Marrow Stem Cell Device 4MedNet Solutions Again Recognized as one of the Fastest Growing US Companies 2
Modified and insect cell culture tested....
Bethyl Laboratories Epitope Retrieval Buffer-Reduced pH will unmask antigenic sites from formaldehyde fixation and allow for subsequent immunostaining. Shelf-Life: 1 year from date of receipt...
Mycoplasma and virus tested...
Edited by Benjamin Lewin (1997) • This book gives an integrated account of the structure and function of genes in both prokaryotic organisms and is thoroughly up to date with the latest thinking...
Biology Products: