Navigation Links
'Jack Spratt' diabetes gene identified
Date:6/1/2012

Type 2 diabetes is popularly associated with obesity and a sedentary lifestyle. However, just as there are obese people without type 2 diabetes, there are lean people with the disease.

It has long been hypothesised that type 2 diabetes in lean people is more 'genetically driven'. A new study from a research team led by the Peninsula College of Medicine and Dentistry (PCMD), University of Exeter, which involved research institutions from around the world, has for the first time proved that lean type 2 diabetes patients have a larger genetic disposition to the disease than their obese counterparts. The study has also identified a new genetic factor associated only with lean diabetes sufferers.

The study is published in PLoS Genetics.

Using genetic data from genome-wide association studies, the research team tested genetic markers across the genome in approximately 5,000 lean patients with type 2 diabetes, 13,000 obese patients with the disease and 75,000 healthy controls.

The team found differences in genetic enrichment between lean and obese cases, which support the hypothesis that lean diabetes sufferers have a greater genetic predisposition to the disease. This is in contrast to obese patients with type 2 diabetes, where factors other than type 2 diabetes genes are more likely to be responsible. In addition, genetic variants near the gene, LAMA1, were linked to type 2 diabetes risk for the first time, with an effect that appeared only in the lean patients.

Dr. John Perry, one of the lead authors of the study, said: "Whenever a new disease gene is found, there is always the potential for it to be used as a drug target for new therapies or as a biomarker, but more work is needed to see whether or not this new gene has that potential."

He added: "This is the first time that a type 2 diabetes gene has been found to act in this way we do not know why it should be associated in one sub-group of patients
'/>"/>

Contact: Andrew Gould
andrew.gould@pcmd.ac.uk
44-018-843-8346
University of Exeter
Source:Eurekalert

Page: 1 2

Related biology news :

1. To spread, nervous system viruses sabotage cell, hijack transportation
2. To drive infections, a hijacking virus mimics a cells signaling system
3. UGA scientists hijack bacterial immune system
4. Hepatitis C virus hijacks liver microRNA
5. Newfound hijacked proteins linked to salmonella virulence
6. Jackson Pollock, artist and physicist?
7. NCI partners with Jackson Laboratory, UC Davis to speed cancer clinical trials
8. What is a laboratory mouse? Jackson, UNC researchers reveal the details
9. Sale of sports car benefits TGen cancer fund named for Jackson family
10. Jackson Laboratory and Tufts University announce new Ph.D. track in mammalian genetics
11. Blast from the past: Jack pine genetics support a coastal glacial refugium
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... Strict laws against distracted driving and the ... American and European automotive sector towards gesture recognition technologies. ... that are intuitive and able to retrieve information with ... New analysis from Frost & Sullivan,s Strategic ... Europe and North America ...
(Date:11/18/2014)... 17, 2014 The Parenteral Drug Association (PDA) today ... will speak and at least seven more will participate in ... Omni Shoreham Hotel in Washington D.C. , ... have significant support from the regulatory agencies in ... in our effort to help advance the use of ...
(Date:11/10/2014)... Laundry detergent pods began appearing on U.S. store shelves ... growing numbers ever since. The small packets can be ... measure out a liquid or powder. The convenience, though, ... new study from researchers at Nationwide Children,s Hospital found ... received reports of 17,230 children younger than 6 years ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Study finds laundry detergent pods, serious poisoning risk for children 2
... 2013, New York, NY Ludwig researchers have elucidated a ... metabolize glucose to generate the energy and raw materials ... in Cell Metabolism , the Ludwig Cancer Research ... harnesses the mechanism to resist targeted therapies that should ...
... steer clear of dirt but their wild cousins can,t be ... a result. A study of wild mice has shown ... material and droppings left by other mice. Choosing a ... an increased risk of disease from other animals, dirt, the findings ...
... that individual "molecular muscles" within cells respond to different types ... the environment and appropriately adapt their shapes and activities. ... the journal Nature Materials , specifically sheds light on ... A computer model the researchers developed, they add, ...
Cached Biology News:Targeting cancer's sweet tooth 2Targeting cancer's sweet tooth 3Clean living is a luxury wild animals can't afford, study suggests 2Cells' 'molecular muscles' help them sense and respond to their environments 2Cells' 'molecular muscles' help them sense and respond to their environments 3
(Date:12/17/2014)... San Diego, CA (PRWEB) December 17, 2014 ... strategy and activation agency and member of the Huntsworth ... Jamie Gonzales to its executive team. In her role, ... Services. , “We are incredibly honored to welcome ... said Agency Chief and CEO, Gaëtan Fraikin. “She is ...
(Date:12/17/2014)... SILVER SPRING, Md. , Dec. 17, 2014 /PRNewswire/ ... today two senior executive promotions as well as changes ... Senior Executive Promotions United ... Ph.D. to President and Co-Chief Executive Officer and ... Chief Operating Officer.  In connection with these promotions, Dr. ...
(Date:12/17/2014)... SAN FRANCISCO, Calif. , Dec. 17, 2014 ... results of a Phase 2 study evaluating the ... the treatment of patients with severe, chronic itch ... current standard of care, including topical steroids and ... was percent change in Visual Analog Scale (VAS) ...
(Date:12/15/2014)... December 15, 2014 METTLER TOLEDO ... PVM tool, ParticleView V19 with PVM technology ... probe-based particle vision and measurement tool continuously captures ... conditions. ParticleView V19 then automatically prepares a report ... particle size and concentration changes. This compelling blend ...
Breaking Biology Technology:Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2
... California. , Dynal : 400+ employees worldwide, 87 in ... Norway. Brown Deer, Wis. California-based ... ASA , whose U.S. operations are based in Brown ... million. , ,Invitrogen has considered the acquisition since ...
... venture capital performance in the U.S. during 2004. , ,We ... share of this investment as well as how the life science ... detailed look at how the life science industry in the Midwest ... report. , ,Still, I was able to ferret out some ...
... written about the important impact that generic pharmaceutical drugs ... Their rise and growth spurs Big Pharma to invest ... Americans not having any kind of medical health insurance ... medicines from Canada being rapidly shut by U.S. pharmaceutical ...
Cached Biology Technology:Invitrogen to buy Norwegian biotech with operations in Brown Deer 2Midwest VC investment up in 2004, but number of deals down 2Midwest VC investment up in 2004, but number of deals down 3Pharmas will be forced into generic-drug strategy 2Pharmas will be forced into generic-drug strategy 3
... Protein Solubility Service, We deliversoluble protein ... SOS technology yields the best soluble protein ... on each clone submitted , Powerful results ... new protein Solubility Optimization Service (SOS) uses ...
... Multi-Disciplinary Team The ... is a stand-alone work center dedicated ... array manufacturing. The facilitys experienced project ... Planning and Marketing professionals, work closely ...
... scale kinase profiling, quantitative measurement of ... research built on the flexible and ... These microarrays are available as part ... - Peptide Microarray Service. ...
... commonly used technique for studying protein function ... on SDS-PAGE and transferred to a membrane ... are probed with specific antibodies. Unlike nucleic ... Southern and Northern blots, it has been ...
Biology Products: