Navigation Links
JDRF funded study links 'hygiene hypothesis' to diabetes prevention
Date:10/6/2008

New York, NY, October 6, 2008 -- A research study funded by JDRF suggests that a common intestinal bacteria may provide some protection from developing type 1 diabetes. The findings provide an important step towards understanding how and why type 1 diabetes develops in people, and may lead to potential cures.

The study, reported this week in Nature Magazine, lends further support to the "hygiene hypothesis," that exposure to an appropriate amount and composition of bacteria may be important to living a healthy life, and that susceptibility to type 1 diabetes and other autoimmune disorders may actually be caused by a lack of exposure to certain parasites and microbes.

In the study, researchers at Yale University and the University of Chicago found that exposure to certain bacteria will trigger an immune system response in mice. That response is believed to be what prevents autoimmune disorders -- conditions where the immune system attacks healthy cells in the body. In people with type 1 diabetes, the immune system attacks the beta cells in the pancreas, stopping a person's ability to detect glucose and produce insulin. For the purposes of the study, the bacteria used were harmless microbes typically found in the human intestine. The scientists suggest that safe, measured exposure to certain bacteria may lower the risk of immune disorders.

"This study outcome gives us a new avenue to explore", said JDRF Executive Vice President of Research, Richard A. Insel, MD. "And, with type 1 diabetes in the U.S. and many countries around the world at about a 3% annual rate, every lead is significant. The research gives impetus to better understanding how the bacterial flora in our body influences host immune defenses and responses that provide resistance to the development of type 1 diabetes. This understanding may provide new therapeutic approaches to prevention."

For the study, teams led by Li Wen at Yale and Alexander V. Chervonsky at the University of Chicago used mice that under normal conditions, would not develop diabetes. If raised in a germ-free environment, however, the mice developed diabetes. But mice that were exposed to common intestinal bacteria maintained a lower risk for the disease.


'/>"/>

Contact: Michael Cook
mcook@jdrf.org
212-479-7510
Juvenile Diabetes Research Foundation International
Source:Eurekalert

Related biology news :

1. Mandate for public access to NIH-funded research poised to become law
2. Irritating smells alert special cells, NIH-funded study finds
3. OSU technologies funded for development
4. JDRF-funded clinical trial demonstrates continuous glucose monitoring improves blood sugar control
5. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
6. A study by the MUHC and McGill University opens a new door to understanding cancer
7. Study begins to reveal clues to the cause and progression of sepsis
8. Clones on task serve greater good, evolutionary study shows
9. New study warns limited carbon market puts 20 percent of tropical forest at risk
10. New study examines how rearing environment can alter navigation
11. Study links cat disease to flame retardants in furniture and to pet food
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... 2016   LegacyXChange, ... "Company") LegacyXChange is excited to release its ... to be launched online site for trading 100% guaranteed ... will also provide potential shareholders a sense of the ... an industry that is notorious for fraud. The video ...
(Date:3/29/2016)... March 29, 2016 LegacyXChange, Inc. ... "LEGX" and SelectaDNA/CSI Protect are pleased to announce our ... in a variety of writing instruments, ensuring athletes signatures ... created collectibles from athletes on LegacyXChange will be assured ... the DNA. Bill Bollander , CEO ...
(Date:3/22/2016)... , March 22, 2016 ... report "Electronic Sensors Market for Consumer Industry by Type ... Others), Application (Communication & IT, Entertainment, Home ... Global Forecast to 2022", published by MarketsandMarkets, ... expected to reach USD 26.76 Billion by ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016   Boston Biomedical ... novel compounds designed to target cancer stemness pathways, ... been granted Orphan Drug Designation from the U.S. ... of gastric cancer, including gastroesophageal junction (GEJ) cancer. ... designed to inhibit cancer stemness pathways by targeting ...
(Date:6/23/2016)... , June 23, 2016 A person commits a ... crime scene to track the criminal down. An ... Food and Drug Administration (FDA) uses DNA evidence to track ... Sound far-fetched? It,s not. The FDA has increasingly ... support investigations of foodborne illnesses. Put as simply as possible, ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... and Mold) microbial test has received AOAC Research Institute approval 061601. , “This ... introduced last year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. ...
(Date:6/23/2016)... YORK , June, 23, 2016  The Biodesign ... to envision new ways to harness living systems and ... Modern Art (MoMA) in New York City ... than 130 participating students, showcased projects at MoMA,s Celeste ... Paola Antonelli , MoMA,s senior curator of architecture ...
Breaking Biology Technology: